Comparing MEG and EEG in detecting the ∼20-Hz rhythm modulation to tactile and proprioceptive stimulation

Modulation of the ∼20-Hz brain rhythm has been used to evaluate the functional state of the sensorimotor cortex both in healthy subjects and patients, such as stroke patients. The ∼20-Hz brain rhythm can be detected by both magnetoencephalography (MEG) and electroencephalography (EEG), but the comparability of these methods has not been evaluated. Here, we compare these two methods in the evaluating of ∼20-Hz activity modulation to somatosensory stimuli. Rhythmic ∼20-Hz activity during separate tactile and proprioceptive stimulation of the right and left index finger was recorded simultaneously with MEG and EEG in twenty-four healthy participants. Both tactile and proprioceptive stimulus produced a clear suppression at 300–350 ms followed by a subsequent rebound at 700–900 ms after stimulus onset, detected at similar latencies both with MEG and EEG. The relative amplitudes of suppression and rebound correlated strongly between MEG and EEG recordings. However, the relative strength of suppression and rebound in the contralateral hemisphere (with respect to the stimulated hand) was significantly stronger in MEG than in EEG recordings. Our results indicate that MEG recordings produced signals with higher signal-to-noise ratio than EEG, favoring MEG as an optimal tool for studies evaluating sensorimotor cortical functions. However, the strong correlation between MEG and EEG results encourages the use of EEG when translating studies to clinical practice. The clear advantage of EEG is the availability of the method in hospitals and bed-side measurements at the acute phase.Peer reviewe

Effect of Sensory Attenuation on Cortical Movement-Related Oscillations

This study examined the impact of induced sensory deficits on cortical, movement-related oscillations measured using electroencephalography (EEG). We hypothesized that EEG patterns in healthy subjects with induced sensory reduction would be comparable to EEG found after chronic loss of sensory feedback. EEG signals from 64 scalp locations were measured from 10 healthy subjects. Participants dorsiflexed their ankle after prolonged vibration of the tibialis anterior (TA). Beta band time frequency decompositions were calculated using wavelets and compared across conditions. Changes in patterns of movement-related brain activity were observed following attenuation of sensory feedback. A significant decrease in beta power of event-related synchronization was associated with simple ankle dorsiflexion after prolonged vibration of the TA. Attenuation of sensory feedback in young, healthy subjects led to a corresponding decrease in beta band synchronization. This temporary change in beta oscillations suggests that these modulations are a mechanism for sensorimotor integration. The loss of sensory feedback found in spinal cord injury patients contributes to changes in EEG signals underlying motor commands. Similar alterations in cortical signals in healthy subjects with reduced sensory feedback implies these changes reflect normal sensorimotor integration after reduced sensory input rather than brain plasticity

Spatial inhibition of return promotes changes in Response-related mu and beta oscillatory patterns

The possible role that response processes play in Inhibition of Return (IOR), traditionally associated with reduced or inhibited attentional processing of spatially cued target stimuli presented at cue-target intervals longer than 300 ms, is still under debate. Previous psychophysiological studies on response-related Electroencephalographic (EEG) activity and IOR have found divergent results. Considering that the ability to optimize our behavior not only resides in our capacity to inhibit the focus of attention from irrelevant information but also to inhibit or reduce motor activation associated with responses to that information, it is conceivable that response processes are also affected by IOR. In the present study, time–frequency (T–F) analyses were performed on EEG oscillatory activity between 2 and 40 Hz to check whether spatial IOR affects response preparation and execution during a visuospatial attention task. To avoid possible spatial stimulus–response compatibility effects and their interaction with the IOR effects, the stimuli were presented along the vertical meridian of the visual field. The results differed between lower and upper visual fields. In the lower visual field spatial IOR was related to a synchronization in the pre-movement mu band at bilateral precentral and central electrodes, and in the post-movement beta band at contralateral precentral and central electrodes, which may be associated with an attention-driven reduction of somatomotor processing prior to the execution of responses to relevant stimuli presented at previously cued locations followed by a post-movement deactivation of motor areas. In the upper visual field, spatial IOR was associated with a decrease in desynchronization around response execution in the beta band at contralateral postcentral electrodes that might indicate a late (last moment) reduction of motor activation when responding to spatially cued targets. The present results suggest that different response processes are affected by spatial IOR depending on the visual field where the target is presented. 2015 IBRO. Published byThis study was supported by grants from the Spanish MICINN (PSI2010-21427), Spanish MINECO (PSI2014-53743-P), and Xunta de Galicia (10PXIB211220PR)S

Cortical response variability is driven by local excitability changes with somatotopic organization

Identical sensory stimuli can lead to different neural responses depending on the instantaneous brain state. Specifically, neural excitability in sensory areas may shape the brain’s response already from earliest cortical processing onwards. However, whether these dynamics affect a given sensory domain globally or occur on a spatially local level is largely unknown. We studied this in the somatosensory domain of 38 human participants with EEG, presenting stimuli to the median and tibial nerves alternatingly, and testing the co-variation of initial cortical responses in hand and foot areas, as well as their relation to pre-stimulus oscillatory states. We found that amplitude fluctuations of initial cortical responses to hand and foot stimulation – the N20 and P40 components of the somatosensory evoked potential (SEP), respectively – were not related, indicating local excitability changes in primary sensory regions. In addition, effects of pre-stimulus alpha (8-13 Hz) and beta (18-23 Hz) band amplitude on hand-related responses showed a robust somatotopic organization, thus further strengthening the notion of local excitability fluctuations. However, for foot-related responses, the spatial specificity of pre-stimulus effects was less consistent across frequency bands, with beta appearing to be more foot-specific than alpha. Connectivity analyses in source space suggested this to be due to a somatosensory alpha rhythm that is primarily driven by activity in hand regions while beta frequencies may operate in a more hand-region-independent manner. Altogether, our findings suggest spatially distinct excitability dynamics within the primary somatosensory cortex, yet with the caveat that frequency-specific processes in one sub-region may not readily generalize to other sub-regions

Large scale neural dynamics of rhythmic sensorimotor coordination and stability

Coordination Dynamics posits that the stability of coordinated patterns of movement may be a key variable for organizing neural activity underlying coordinated action. In support, recent findings suggest that premotor areas play an important role in maintaining pattern stability. The present EEG study investigates how changes in neural activation (assessed via event-related power) are affected both by rate and stability of coordination. Nineteen participants coordinated finger taps with an auditory metronome in either a synchronized or syncopated pattern presented at five different rates (1.00, 1.25, 1.50, 1.75, and 2.00 Hz). Premotor areas demonstrated increases in event-related synchronization (neural deactivation) within the alpha band following slow, synchronized movements. Stepwise increases in rate led to greater desynchronization (neural activation) throughout the entire duration of the movement cycle. During syncopation medial premotor regions remained desynchronized during movement. Moreover, medial premotor was more involved during synchronization with subsequent increases in movement rate. Counter to previous findings, medial premotor did not modulate changes in coordination stability. We suggested that medial premotor regions are involved in processes related to the coincidence of the finger tap and auditory tone. These findings support premotor cortex\u27s role in motor inhibition, timing, and execution

Mapping the Spatial and Temporal Dynamics of Sensorimotor Integration During the Perception and Performance of Wallowing

Similar to other complex sequences of muscle activity, swallowing relies heavily upon ‘sensorimotor integration.’ It is well known that the premotor cortex and primary sensorimotor cortices provide critical sensorimotor contributions that help control the strength and timing of swallowing muscle effectors. However, the temporal dynamics of sensorimotor integration remains unclear, even when performed normally without neurological compromise. Recent advances in EEG analysis blind source separation techniques via independent component analysis offer a novel and exciting opportunity to measure cortical sensorimotor activity in realtime during swallowing, concurrently with muscle activity during swallow initiation. In the current study, mu components were identified, with characteristic alpha (~10 Hz) and beta (~20 Hz) frequency bands. Spectral power within these frequency bands are known to index somatosensory and motor activity, respectively. Twenty-five adult participants produced swallowing and tongue tapping (motor control) tasks. Additionally they were asked to watch a video depicting swallowing and a scrambled kaleidoscope (perceptual control) version of this same video. Independent component analysis of raw EEG signals identified bilateral clusters of mu components, maximally localized to the premotor cortex (BA6) in 19 participants during the production and the perception tasks. Event related spectral perturbation (ERSP) analysis was used to identify spectral power within alpha and beta peaks of the mu cluster across time. Alpha and beta event-related desynchronization (ERD), indicative of somatosensory and motor activity, was revealed for both tongue tapping and swallowing beginning at ~500 ms following a visual cue to “go.” However, the patterns of ERD are stronger (pFD

Subjective pain perception mediated by alpha rhythms

Suppression of spontaneous alpha oscillatory activities, interpreted as cortical excitability, was observed in response to both transient and tonic painful stimuli. The changes of alpha rhythms induced by pain could be modulated by painful sensory inputs, experimental tasks, and top-down cognitive regulations such as attention. The temporal and spatial characteristics, as well as neural functions of pain induced alpha responses, depend much on how these factors contribute to the observed alpha event-related desynchronization/synchronization (ERD/ERS). How sensory-, task-, and cognitive-related changes of alpha oscillatory activities interact in pain perception process is reviewed in the current study, and the following conclusions are made: (1) the functional inhibition hypothesis that has been proposed in auditory and visual modalities could be applied also in pain modality; (2) the neural functions of pain induced alpha ERD/ERS were highly dependent on the cortical regions where it is observed, e.g., somatosensory cortex alpha ERD/ERS in pain perception for painful stimulus processing; (3) the attention modulation of pain perception, i.e., influences on the sensory and affective dimensions of pain experience, could be mediated by changes of alpha rhythms. Finally, we propose a model regarding the determinants of pain related alpha oscillatory activity, i.e., sensory-discriminative, affective-motivational, and cognitive-modulative aspects of pain experience, would affect and determine pain related alpha oscillatory activities in an integrated way within the distributed alpha system. Copyright © 2015 Elsevier B.V. All rights reserved.postprin

Cortical Oscillations During a Lateral Balance Perturbation While Walking

The role of sensory systems in the cortical control of dynamic balance was examined using electroencephalography (EEG) recordings during balance perturbations while walking. Specifically, we examined the impact of sensory deficits on cortical oscillations using vibratory stimuli to suppress sensory feedback and by comparing cortical oscillations during balance perturbations while walking in people with sensory deficits associated with cervical myelopathy and neurologically intact controls. Balance during walking provides a rich framework for investigating cortical control using EEG during a functionally relevant task. While this approach is promising, substantial technical challenges remain in recording and processing EEG in the noisy, artifact laden environment associated with walking. We therefore first investigated the role of sensory attenuation in healthy, adult controls within the framework of a simple, motor task. We then examined the effectiveness of using independent component analysis and additional machine learning techniques such as clustering and linear classifiers for differentiating noise from actual brain activity in EEG signals during walking. Finally, we examined a more complicated experimental framework using a custom cable-servomotor system to deliver a lateral pull to the waist of participants with cervical myelopathy while walking and measured their cortical activity using high density EEG. We observed that the attenuation of sensory input in healthy controls induced a similar change in beta band modulation as found previously in spinal cord injury for simple movements of the ankle. During walking, large increases in theta band power throughout the cortex were observed to modulate with lateral balance perturbations. Theta band modulations in the frontal areas of the cortex were significantly delayed in time and displayed a more spatially lateralized cortical localization for participants with cervical myelopathy compared to age-matched, healthy controls. The timing of these theta power modulations were significantly correlated with the initiation of a widening step width correction in response to the balance perturbation. Our results support a link between the modulation of cortical oscillations and sensorimotor integration in simple and complex motor paradigms

What Happens in Between? Human Oscillatory Brain Activity Related to Crossmodal Spatial Cueing

Previous studies investigated the effects of crossmodal spatial attention by comparing the responses to validly versus invalidly cued target stimuli. Dynamics of cortical rhythms in the time interval between cue and target might contribute to cue effects on performance. Here, we studied the influence of spatial attention on ongoing oscillatory brain activity in the interval between cue and target onset. In a first experiment, subjects underwent periods of tactile stimulation (cue) followed by visual stimulation (target) in a spatial cueing task as well as tactile stimulation as a control. In a second experiment, cue validity was modified to be 50%, 75%, or else 25%, to separate effects of exogenous shifts of attention caused by tactile stimuli from that of endogenous shifts. Tactile stimuli produced: 1) a stronger lateralization of the sensorimotor beta-rhythm rebound (15–22 Hz) after tactile stimuli serving as cues versus not serving as cues; 2) a suppression of the occipital alpha-rhythm (7–13 Hz) appearing only in the cueing task (this suppression was stronger contralateral to the endogenously attended side and was predictive of behavioral success); 3) an increase of prefrontal gamma-activity (25–35 Hz) specifically in the cueing task. We measured cue-related modulations of cortical rhythms which may accompany crossmodal spatial attention, expectation or decision, and therefore contribute to cue validity effects. The clearly lateralized alpha suppression after tactile cues in our data indicates its dependence on endogenous rather than exogenous shifts of visuo-spatial attention following a cue independent of its modality

Neuromagnetic investigations of mechanisms and effects of STN-DBS and medication in Parkinson's disease

Parkinson’s disease (PD) is a neurodegenerative disorder cardinally marked by motor symptoms, but also sensory symptoms and several other non-motor symptoms. PD patients are typically treated with dopaminergic medication for several years. Many patients eventually experience bouts of periods where medication might not be able to effectively control symptoms as well as experience side-effects of long-term dopaminergic treatments. Deep brain stimulation (DBS) is an option as the next therapeutic recourse for such patients. DBS treatment essentially involves placement of stimulating electrodes in the subthalamic nucleus (STN) or the globus pallidus internum (GPi) along with an implanted pulse generator (IPG) in the sub-clavicular space. STN-DBS alleviates motor symptoms and leads to substantial improvements in quality of life for PD patients. Although DBS is known to improve several classes of symptoms, the effect mechanism of DBS is still not clear. While there is a lack of electrophysiological investigation of sensory processing and the effects of treatments in PD altogether, the electrophysiological studies of the cortical dynamics during motor tasks and at rest lack consensus.We recorded magnetoencephalography (MEG) and electromyography (EMG) from PD patients in three studies: (i) at rest, (ii) during median nerve stimulation, and (iii) while performing phasic contractions (hand gripping). The three studies focused on cortical oscillatory dynamics at rest, during somatosensory processing and during movement, respectively. The measurements were conducted in DBS-treated, untreated (DBS washout) and dopaminergic-medicated states. While both treatments (DBS and dopaminergic medication) ameliorated motor symptoms similarly in all studies, they showed differentiated effects on: (i) increased sensorimotor cortical low-gamma spectral power (31-45 Hz) (but no changes in beta power (13-30 Hz)) at rest only during DBS, (ii) somatosensory processing with higher gamma augmentation (31-45 Hz, 20-60 ms) in the dopaminergic-medicated state compared to DBS-treated and untreated states, and (iii) hand gripping with increased motor-related beta corticomuscular coherence (CMC, 13-30 Hz) during dopaminergic medication in contrast to increased gamma power (31-45 Hz) during DBS.Firstly, we infer from the three studies that DBS and dopaminergic medication employ partially different anatomo-functional pathways and functional strategies when improving PD symptoms. Secondly, we suggest that treatments act on pathological oscillatory dynamics differently at cortical and sub-cortical levels and may do so through more sophisticated mechanisms than mere suppression of the pathological spectral power in a particular band. And thirdly, we urge exploring effect mechanisms of PD treatments beyond the motor system. The effects of dopaminergic medication on early somatosensory processing has opened the door for exploring the effects of treatments and studying their mechanisms using electrophysiology, especially in higher order sensory deficits. Integration of such research findings into a holistic view on mechanisms of treatments could pave way for better disease management paradigms.