A note on QUBO instances defined on Chimera graphs

McGeoch and Wang (2013) recently obtained optimal or near-optimal solutions to some quadratic unconstrained boolean optimization (QUBO) problem instances using a 439 qubit D-Wave Two quantum computing system in much less time than with the IBM ILOG CPLEX mixed-integer quadratic programming (MIQP) solver. The problems studied by McGeoch and Wang are defined on subgraphs -- with up to 439 nodes -- of Chimera graphs. We observe that after a standard reformulation of the QUBO problem as a mixed-integer linear program (MILP), the specific instances used by McGeoch and Wang can be solved to optimality with the CPLEX MILP solver in much less time than the time reported in McGeoch and Wang for the CPLEX MIQP solver. However, the solution time is still more than the time taken by the D-Wave computer in the McGeoch-Wang tests.Comment: Version 1 discussed computational results with random QUBO instances. McGeoch and Wang made an error in describing the instances they used; they did not use random QUBO instances but rather random Ising Model instances with fields (mapped to QUBO instances). The current version of the note reports on tests with the precise instances used by McGeoch and Wan

QuASeR -- Quantum Accelerated De Novo DNA Sequence Reconstruction

In this article, we present QuASeR, a reference-free DNA sequence reconstruction implementation via de novo assembly on both gate-based and quantum annealing platforms. Each one of the four steps of the implementation (TSP, QUBO, Hamiltonians and QAOA) is explained with simple proof-of-concept examples to target both the genomics research community and quantum application developers in a self-contained manner. The details of the implementation are discussed for the various layers of the quantum full-stack accelerator design. We also highlight the limitations of current classical simulation and available quantum hardware systems. The implementation is open-source and can be found on https://github.com/prince-ph0en1x/QuASeR.Comment: 24 page

Towards Hybrid Classical-Quantum Computation Structures in Wirelessly-Networked Systems

With unprecedented increases in traffic load in today's wireless networks, design challenges shift from the wireless network itself to the computational support behind the wireless network. In this vein, there is new interest in quantum-compute approaches because of their potential to substantially speed up processing, and so improve network throughput. However, quantum hardware that actually exists today is much more susceptible to computational errors than silicon-based hardware, due to the physical phenomena of decoherence and noise. This paper explores the boundary between the two types of computation---classical-quantum hybrid processing for optimization problems in wireless systems---envisioning how wireless can simultaneously leverage the benefit of both approaches. We explore the feasibility of a hybrid system with a real hardware prototype using one of the most advanced experimentally available techniques today, reverse quantum annealing. Preliminary results on a low-latency, large MIMO system envisioned in the 5G New Radio roadmap are encouraging, showing approximately 2--10X better performance in terms of processing time than prior published results.Comment: HotNets 2020: Nineteenth ACM Workshop on Hot Topics in Networks (https://doi.org/10.1145/3422604.3425924