Resolving Structure in Human Brain Organization: Identifying Mesoscale Organization in Weighted Network Representations

Human brain anatomy and function display a combination of modular and hierarchical organization, suggesting the importance of both cohesive structures and variable resolutions in the facilitation of healthy cognitive processes. However, tools to simultaneously probe these features of brain architecture require further development. We propose and apply a set of methods to extract cohesive structures in network representations of brain connectivity using multi-resolution techniques. We employ a combination of soft thresholding, windowed thresholding, and resolution in community detection, that enable us to identify and isolate structures associated with different weights. One such mesoscale structure is bipartivity, which quantifies the extent to which the brain is divided into two partitions with high connectivity between partitions and low connectivity within partitions. A second, complementary mesoscale structure is modularity, which quantifies the extent to which the brain is divided into multiple communities with strong connectivity within each community and weak connectivity between communities. Our methods lead to multi-resolution curves of these network diagnostics over a range of spatial, geometric, and structural scales. For statistical comparison, we contrast our results with those obtained for several benchmark null models. Our work demonstrates that multi-resolution diagnostic curves capture complex organizational profiles in weighted graphs. We apply these methods to the identification of resolution-specific characteristics of healthy weighted graph architecture and altered connectivity profiles in psychiatric disease.Comment: Comments welcom

Hamilton cycles in graphs and hypergraphs: an extremal perspective

As one of the most fundamental and well-known NP-complete problems, the Hamilton cycle problem has been the subject of intensive research. Recent developments in the area have highlighted the crucial role played by the notions of expansion and quasi-randomness. These concepts and other recent techniques have led to the solution of several long-standing problems in the area. New aspects have also emerged, such as resilience, robustness and the study of Hamilton cycles in hypergraphs. We survey these developments and highlight open problems, with an emphasis on extremal and probabilistic approaches.Comment: to appear in the Proceedings of the ICM 2014; due to given page limits, this final version is slightly shorter than the previous arxiv versio

Eigenvalues and Perfect Matchings

AMS classification: 05C50, 05C70, 05E30.graph;perfect matching;Laplacian matrix;eigenvalues.