4,856 research outputs found
A Likelihood-Free Inference Framework for Population Genetic Data using Exchangeable Neural Networks
An explosion of high-throughput DNA sequencing in the past decade has led to
a surge of interest in population-scale inference with whole-genome data.
Recent work in population genetics has centered on designing inference methods
for relatively simple model classes, and few scalable general-purpose inference
techniques exist for more realistic, complex models. To achieve this, two
inferential challenges need to be addressed: (1) population data are
exchangeable, calling for methods that efficiently exploit the symmetries of
the data, and (2) computing likelihoods is intractable as it requires
integrating over a set of correlated, extremely high-dimensional latent
variables. These challenges are traditionally tackled by likelihood-free
methods that use scientific simulators to generate datasets and reduce them to
hand-designed, permutation-invariant summary statistics, often leading to
inaccurate inference. In this work, we develop an exchangeable neural network
that performs summary statistic-free, likelihood-free inference. Our framework
can be applied in a black-box fashion across a variety of simulation-based
tasks, both within and outside biology. We demonstrate the power of our
approach on the recombination hotspot testing problem, outperforming the
state-of-the-art.Comment: 9 pages, 8 figure
Adaptive Reduced Rank Regression
We study the low rank regression problem , where and are and dimensional
vectors respectively. We consider the extreme high-dimensional setting where
the number of observations is less than . Existing algorithms
are designed for settings where is typically as large as
. This work provides an efficient algorithm which
only involves two SVD, and establishes statistical guarantees on its
performance. The algorithm decouples the problem by first estimating the
precision matrix of the features, and then solving the matrix denoising
problem. To complement the upper bound, we introduce new techniques for
establishing lower bounds on the performance of any algorithm for this problem.
Our preliminary experiments confirm that our algorithm often out-performs
existing baselines, and is always at least competitive.Comment: 40 page
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Understanding Model-Based Reinforcement Learning and its Application in Safe Reinforcement Learning
Model-based reinforcement learning algorithms have been shown to achieve successful results on various continuous control benchmarks, but the understanding of model-based methods is limited. We try to interpret how model-based method works through novel experiments on state-of-the-art algorithms with an emphasis on the model learning part. We evaluate the role of the model learning in policy optimization and propose methods to learn a more accurate model. With a better understanding of model-based reinforcement learning, we then apply model-based methods to solve safe reinforcement learning (RL) problems with near-zero violation of hard constraints throughout training. Drawing an analogy with how humans and animals learn to perform safe actions, we break down the safe RL problem into three stages. First, we train agents in a constraint-free environment to learn a performant policy for reaching high rewards, and simultaneously learn a model of the dynamics. Second, we use model-based methods to plan safe actions and train a safeguarding policy from these actions through imitation. Finally, we propose a factored framework to train an overall policy that mixes the performant policy and the safeguarding policy. This three-step curriculum ensures near-zero violation of safety constraints at all times. As an advantage of model-based method, the sample complexity required at the second and third steps of the process is significantly lower than model-free methods and can enable online safe learning. We demonstrate the effectiveness of our methods in various continuous control problems and analyze the advantages over state-of-the-art approaches
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