Cerebellar output controls generalized spike-and-wave discharge occurence

© 2015 The Authors Annals of Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (CC BY-NC-ND 4.0) which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.Disrupting thalamocortical activity patterns has proven to be a promising approach to stop generalized spike-and-wave discharges (GSWDs) characteristic of absence seizures. Here, we investigated to what extent modulation of neuronal firing in cerebellar nuclei (CN), which are anatomically in an advantageous position to disrupt cortical oscillations through their innervation of a wide variety of thalamic nuclei, is effective in controlling absence seizuresPeer reviewedFinal Published versio

Oscillator models of the solar cycle: Towards the development of inversion methods

This article reviews some of the leading results obtained in solar dynamo physics by using temporal oscillator models as a tool to interpret observational data and dynamo model predictions. We discuss how solar observational data such as the sunspot number is used to infer the leading quantities responsible for the solar variability during the last few centuries. Moreover, we discuss the advantages and difficulties of using inversion methods (or backward methods) over forward methods to interpret the solar dynamo data. We argue that this approach could help us to have a better insight about the leading physical processes responsible for solar dynamo, in a similar manner as helioseismology has helped to achieve a better insight on the thermodynamic structure and flow dynamics in the Sun's interior.Comment: 28 pages; 16 figures, ISSI Workshop 11-15 November 2013 - The Solar Cycle, http://www.issibern.ch/program/workshops.htm

ECGAN: Self-supervised generative adversarial network for electrocardiography

High-quality synthetic data can support the development of effective predictive models for biomedical tasks, especially in rare diseases or when subject to compelling privacy constraints. These limitations, for instance, negatively impact open access to electrocardiography datasets about arrhythmias. This work introduces a self-supervised approach to the generation of synthetic electrocardiography time series which is shown to promote morphological plausibility. Our model (ECGAN) allows conditioning the generative process for specific rhythm abnormalities, enhancing synchronization and diversity across samples with respect to literature models. A dedicated sample quality assessment framework is also defined, leveraging arrhythmia classifiers. The empirical results highlight a substantial improvement against state-of-the-art generative models for sequences and audio synthesis