6,988 research outputs found

    Ruthenium metallotherapeutics: a targeted approach to combatting multidrug resistant pathogens

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    The discovery of antibiotics revolutionised healthcare practice. However due to overuse, inappropriate use, widespread prophylaxis therapy and the lack of new developments, the threat of antimicrobial resistance is now a major global threat to health. By 2050, it is estimated that mortality due to antimicrobial resistant infections will exceed 10 million people per annum, superseding cancer as the leading cause of global mortality. The use of drug repurposing to identify potential therapies which combat antimicrobial resistance is one potential solution. Metals have been used as antimicrobial agents throughout the history of medicine for a broad range of applications, including the use of Silver as an antimicrobial agent which dates back to antiquity. More recently, Ruthenium metallotherapeutic complexes have been shown to exhibit highly active antimicrobial properties by targeting a range of bacterial species, and in contrast to traditional antibiotics, these compounds are thought to elicit antibacterial activity at multiple sites within the bacterial cell, which may reduce the possibility of resistance evolution. This study aimed to evaluate the antimicrobial activity of a series of Ruthenium metallotherapeutic complexes against multidrug-resistant bacterial pathogens, with a focus on use within wound care applications. Antimicrobial susceptibility assays identified two lead candidates, Hexaammineruthenium (III) chloride and [Chlorido(η6-p-cymene)(N-(4-chlorophenyl)pyridine-2-carbothioamide) ruthenium (II)] chloride which demonstrated activity against Pseudomonas aeruginosa and Staphylococcus aureus respectively with MIC values ranging between 4 μg mL-1 and 16 μg mL-1. Furthermore, Hexaammineruthenium (III) chloride demonstrated antibiofilm activity in both a time and concentration-dependent manner. Synergy studies combining lead complexes with antibiotics demonstrated the potential for use as resistance breakers. Subsequent in vitro infection modelling using scratch assays with skin cell lines, coupled with a 3D full thickness skin wound infection model was used to determine potential applied applications of Hexaammineruthenium (III) chloride for use as topical antimicrobial agent against P. aeruginosa infections. Antimicrobial mechanistic studies demonstrated that Hexaammineruthenium (III) chloride targeted the bacterial cell ultrastructure of P. aeruginosa strain PAO1 as cell perturbations were observed when treated cells were analysed by scanning electron microscopy. Furthermore, exposure of P. aeruginosa PAO1 to Hexaammineruthenium (III) chloride also resulted in a concentration dependent membrane depolarisation, which further supported the antimicrobial mechanistic role. Finally, global changes in gene expression following exposure of P. aeruginosa strain PAO1 to Hexaammineruthenium (III) chloride were explored by RNA sequencing. Genes involved in ribosome function, cofactor biosynthesis and membrane fusion were downregulated, which provided a further insight into the wider mechanisms of antibacterial activity. The research conducted in the present study indicated the potential use of Hexaammineruthenium (III) chloride (and derivatives) as a potential treatment option for chronic wounds infected with P. aeruginosa, which could be applied as either a direct treatment or used within antimicrobial wound care applications

    Fake News: Finding Truth in Strategic Communication

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    Fake news is an old phenomenon that has become a new obsession and a menace to society due to technological advancement and the proliferation of social media, which has changed traditional journalism norms. As the spread of false information has increased these past few years, it has become increasingly difficult for information consumers to distinguish between facts and fakes. A comprehensive systematic literature review to extract themes revealed the major factors responsible for spreading fake news. This qualitative interpretative meta-synthesis (QIMS) aims to better understand and offer solutions to combat fake news. This Ph.D. dissertation will serve as a guide for ethical communication practice and a reference for future research studies

    Strategy Tripod Perspective on the Determinants of Airline Efficiency in A Global Context: An Application of DEA and Tobit Analysis

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    The airline industry is vital to contemporary civilization since it is a key player in the globalization process: linking regions, fostering global commerce, promoting tourism and aiding economic and social progress. However, there has been little study on the link between the operational environment and airline efficiency. Investigating the amalgamation of institutions, organisations and strategic decisions is critical to understanding how airlines operate efficiently. This research aims to employ the strategy tripod perspective to investigate the efficiency of a global airline sample using a non-parametric linear programming method (data envelopment analysis [DEA]). Using a Tobit regression, the bootstrapped DEA efficiency change scores are further regressed to determine the drivers of efficiency. The strategy tripod is employed to assess the impact of institutions, industry and resources on airline efficiency. Institutions are measured by global indices of destination attractiveness; industry, including competition, jet fuel and business model; and finally, resources, such as the number of full-time employees, alliances, ownership and connectivity. The first part of the study uses panel data from 35 major airlines, collected from their annual reports for the period 2011 to 2018, and country attractiveness indices from global indicators. The second part of the research involves a qualitative data collection approach and semi-structured interviews with experts in the field to evaluate the impact of COVID-19 on the first part’s significant findings. The main findings reveal that airlines operate at a highly competitive level regardless of their competition intensity or origin. Furthermore, the unpredictability of the environment complicates airline operations. The efficiency drivers of an airline are partially determined by its type of business model, its degree of cooperation and how fuel cost is managed. Trade openness has a negative influence on airline efficiency. COVID-19 has toppled the airline industry, forcing airlines to reconsider their business model and continuously increase cooperation. Human resources, sustainability and alternative fuel sources are critical to airline survival. Finally, this study provides some evidence for the practicality of the strategy tripod and hints at the need for a broader approach in the study of international strategies

    Climate Change and Critical Agrarian Studies

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    Climate change is perhaps the greatest threat to humanity today and plays out as a cruel engine of myriad forms of injustice, violence and destruction. The effects of climate change from human-made emissions of greenhouse gases are devastating and accelerating; yet are uncertain and uneven both in terms of geography and socio-economic impacts. Emerging from the dynamics of capitalism since the industrial revolution — as well as industrialisation under state-led socialism — the consequences of climate change are especially profound for the countryside and its inhabitants. The book interrogates the narratives and strategies that frame climate change and examines the institutionalised responses in agrarian settings, highlighting what exclusions and inclusions result. It explores how different people — in relation to class and other co-constituted axes of social difference such as gender, race, ethnicity, age and occupation — are affected by climate change, as well as the climate adaptation and mitigation responses being implemented in rural areas. The book in turn explores how climate change – and the responses to it - affect processes of social differentiation, trajectories of accumulation and in turn agrarian politics. Finally, the book examines what strategies are required to confront climate change, and the underlying political-economic dynamics that cause it, reflecting on what this means for agrarian struggles across the world. The 26 chapters in this volume explore how the relationship between capitalism and climate change plays out in the rural world and, in particular, the way agrarian struggles connect with the huge challenge of climate change. Through a huge variety of case studies alongside more conceptual chapters, the book makes the often-missing connection between climate change and critical agrarian studies. The book argues that making the connection between climate and agrarian justice is crucial

    A Critical Review Of Post-Secondary Education Writing During A 21st Century Education Revolution

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    Educational materials are effective instruments which provide information and report new discoveries uncovered by researchers in specific areas of academia. Higher education, like other education institutions, rely on instructional materials to inform its practice of educating adult learners. In post-secondary education, developmental English programs are tasked with meeting the needs of dynamic populations, thus there is a continuous need for research in this area to support its changing landscape. However, the majority of scholarly thought in this area centers on K-12 reading and writing. This paucity presents a phenomenon to the post-secondary community. This research study uses a qualitative content analysis to examine peer-reviewed journals from 2003-2017, developmental online websites, and a government issued document directed toward reforming post-secondary developmental education programs. These highly relevant sources aid educators in discovering informational support to apply best practices for student success. Developmental education serves the purpose of addressing literacy gaps for students transitioning to college-level work. The findings here illuminate the dearth of material offered to developmental educators. This study suggests the field of literacy research is fragmented and highlights an apparent blind spot in scholarly literature with regard to English writing instruction. This poses a quandary for post-secondary literacy researchers in the 21st century and establishes the necessity for the literacy research community to commit future scholarship toward equipping college educators teaching writing instruction to underprepared adult learners

    Effects of municipal smoke-free ordinances on secondhand smoke exposure in the Republic of Korea

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    ObjectiveTo reduce premature deaths due to secondhand smoke (SHS) exposure among non-smokers, the Republic of Korea (ROK) adopted changes to the National Health Promotion Act, which allowed local governments to enact municipal ordinances to strengthen their authority to designate smoke-free areas and levy penalty fines. In this study, we examined national trends in SHS exposure after the introduction of these municipal ordinances at the city level in 2010.MethodsWe used interrupted time series analysis to assess whether the trends of SHS exposure in the workplace and at home, and the primary cigarette smoking rate changed following the policy adjustment in the national legislation in ROK. Population-standardized data for selected variables were retrieved from a nationally representative survey dataset and used to study the policy action’s effectiveness.ResultsFollowing the change in the legislation, SHS exposure in the workplace reversed course from an increasing (18% per year) trend prior to the introduction of these smoke-free ordinances to a decreasing (−10% per year) trend after adoption and enforcement of these laws (β2 = 0.18, p-value = 0.07; β3 = −0.10, p-value = 0.02). SHS exposure at home (β2 = 0.10, p-value = 0.09; β3 = −0.03, p-value = 0.14) and the primary cigarette smoking rate (β2 = 0.03, p-value = 0.10; β3 = 0.008, p-value = 0.15) showed no significant changes in the sampled period. Although analyses stratified by sex showed that the allowance of municipal ordinances resulted in reduced SHS exposure in the workplace for both males and females, they did not affect the primary cigarette smoking rate as much, especially among females.ConclusionStrengthening the role of local governments by giving them the authority to enact and enforce penalties on SHS exposure violation helped ROK to reduce SHS exposure in the workplace. However, smoking behaviors and related activities seemed to shift to less restrictive areas such as on the streets and in apartment hallways, negating some of the effects due to these ordinances. Future studies should investigate how smoke-free policies beyond public places can further reduce the SHS exposure in ROK

    Economic power dispatch solutions incorporating stochastic wind power generators by moth flow optimizer

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    Optimization encourages the economical and efficient operation of the electrical system. Most power system problems are nonlinear and nonconvex, and they frequently ask for the optimization of two or more diametrically opposed objectives. The numerical optimization revolution led to the introduction of numerous evolutionary algorithms (EAs). Most of these methods sidestep the problems of early convergence by searching the universe for the ideal. Because the field of EA is evolving, it may be necessary to reevaluate the usage of new algorithms to solve optimization problems involving power systems. The introduction of renewable energy sources into the smart grid of the present enables the emergence of novel optimization problems with an abundance of new variables. This study's primary purpose is to apply state-of-the-art variations of the differential evolution (DE) algorithm for single-objective optimization and selected evolutionary algorithms for multi-objective optimization issues in power systems. In this investigation, we employ the recently created metaheuristic algorithm known as the moth flow optimizer (MFO), which allows us to answer all five of the optimal power flow (OPF) difficulty objective functions: (1) reducing the cost of power generation (including stochastic solar and thermal power generation), (2) diminished power, (3) voltage variation, (4) emissions, and (5) reducing both the cost of power generating and emissions. Compared to the lowest figures provided by comparable approaches, MFO's cost of power production for IEEE-30 and IEEE-57 bus architectures is 888.7248perhourand 888.7248 per hour and 31121.85 per hour, respectively. This results in hourly cost savings between 1.23 % and 1.92%. According to the facts, MFO is superior to the other algorithms and might be utilized to address the OPF problem

    Hierarchical Coordinated Fast Frequency Control using Inverter-Based Resources for Next-Generation Power Grids

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    The proportion of inverter-connected renewable energy resources (RES) in the grid is expanding, primarily displacing conventional synchronous generators. This shift significantly impacts the objective of maintaining grid stability and reliable operations. The increased penetration of RESs contributes to the variability of active power supply and a decrease in the rotational inertia of the grid, resulting in faster system dynamics and larger, more frequent frequency events. These emerging challenges could make traditional centralized frequency control strategies ineffective, necessitating the adoption of modern, high-bandwidth control schemes. In this thesis, we propose a novel hierarchical and coordinated real-time frequency control scheme. It leverages advancements in grid monitoring and communication infrastructure to employ local, flexible inverter-based resources for promptly correcting power imbalances in the system. We solve two research problems that, when combined, yield a practical, real-time, next-generation frequency control scheme. This scheme blends localized control with high-bandwidth wide-area coordination. For the first problem, we propose a layered architecture where control, estimation, and optimization tasks are efficiently aggregated and decentralized across the system. This layered control structure, comprising decentralized, distributed, and centralized assets, enables fast, localized control responses to local power imbalances, integrated with wide- area coordination. For the second problem, we propose a data-driven extension to the framework to enhance model flexibility. Achieving high accuracy in system models used for control design is a considerable challenge due to the increasing scale, complexity, and evolving dynamics of the power system. In our proposed approach, we leverage collected data to provide direct data-driven controller designs for fast frequency regulation. The devised scheme ensures swift and effective frequency control for the bulk grid by accurately re-dispatching inverter-based resources (IBRs) to compensate for unmeasured net-load changes. These changes are computed in real-time using frequency and area tie power flow measurements, alongside collected historical data, thus eliminating reliance on proprietary power system models. Validated through detailed simulations under various scenarios such as load increase, generation trips, and three-phase faults, the scheme is practical, provides rapid, localized frequency control, safeguards data privacy, and eliminates the need for system models of the increasingly complex power system

    Accurate Battery Modelling for Control Design and Economic Analysis of Lithium-ion Battery Energy Storage Systems in Smart Grid

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    Adoption of lithium-ion battery energy storage systems (Li-ion BESSs) as a flexible energy source (FES) has been rapid, particularly for active network management (ANM) schemes to facilitate better utilisation of inverter based renewable energy sources (RES) in power systems. However, Li-ion BESSs display highly nonlinear performance characteristics, which are based on parameters such as state of charge (SOC), temperature, depth of discharge (DOD), charge/discharge rate (C-rate), and battery-aging conditions. Therefore, it is important to include the dynamic nature of battery characteristics in the process of the design and development of battery system controllers for grid applications and for techno-economic studies analyzing the BESS economic profitability. This thesis focuses on improving the design and development of Li-ion BESS controllers for ANM applications by utilizing accurate battery performance models based on the second-order equivalent-circuit dynamic battery modelling technique, which considers the SOC, C-rate, temperature, and aging as its performance affecting parameters. The proposed ANM scheme has been designed to control and manage the power system parameters within the limits defined by grid codes by managing the transients introduced due to the intermittence of RESs and increasing the RES penetration at the same time. The validation of the ANM scheme and the effectiveness of controllers that manage the flexibilities in the power system, which are a part of the energy management system (EMS) of ANM, has been validated with the help of simulation studies based on an existing real-life smart grid pilot in Finland, Sundom Smart Grid (SSG). The studies were performed with offline (short-term transient-stability analysis) and real-time (long-term transient analysis) simulations. In long-term simulation studies, the effect of battery aging has also been considered as part of the Li-ion BESS controller design; thus, its impact on the overall power system operation can be analyzed. For this purpose, aging models that can determine the evolving peak power characteristics associated with aging have been established. Such aging models are included in the control loop of the Li-ion BESS controller design, which can help analyse battery aging impacts on the power system control and stability. These analyses have been validated using various use cases. Finally, the impact of battery aging on economic profitability has been studied by including battery-aging models in techno-economic studies.Aurinkosähköjärjestelmien ja tuulivoiman laajamittainen integrointi sähkövoimajärjestelmän eri jännitetasoille on lisääntynyt nopeasti. Uusiutuva energia on kuitenkin luonteeltaan vaihtelevaa, joka voi aiheuttaa nopeita muutoksia taajuudessa ja jännitteessä. Näiden vaihteluiden hallintaan tarvitaan erilaisia joustavia energiaresursseja, kuten energiavarastoja, sekä niiden tehokkaan hyödyntämisen mahdollistaviea älykkäitä ja aktiivisia hallinta- ja ohjausjärjestelmiä. Litiumioniakkuihin pohjautuvien invertteriliitäntäisten energian varastointijärjestelmien käyttö joustoresursseina aktiiviseen verkonhallintaan niiden pätö- ja loistehon ohjauksen avulla on lisääntynyt nopeasti johtuen niiden kustannusten laskusta, modulaarisuudesta ja teknisistä ominaisuuksista. Litiumioniakuilla on erittäin epälineaariset ominaisuudet joita kuvaavat parametrit ovat esimerkiksi lataustila, lämpötila, purkaussyvyys, lataus/ purkausnopeus ja akun ikääntyminen. Akkujen ominaisuuksien dynaaminen luonne onkin tärkeää huomioida myös akkujen sähköverkkoratkaisuihin liittyvien säätöjärjestelmien kehittämisessä sekä teknis-taloudellisissa kannattavuusanalyyseissa. Tämä väitöstutkimus keskittyy ensisijaisesti aktiiviseen verkonhallintaan käytettävien litiumioniakkujen säätöratkaisuiden parantamiseen hyödyntämällä tarkkoja, dynaamisia akun suorituskykymalleja, jotka perustuvat toisen asteen ekvivalenttipiirien akkumallinnustekniikkaan, jossa otetaan huomioon lataustila, lataus/purkausnopeus ja lämpötila. Työssä kehitetyn aktiivisen verkonhallintajärjestelmän avulla tehtävät akun pätö- ja loistehon ohjausperiaatteet on validoitu laajamittaisten simulointien avulla, esimerkiksi paikallista älyverkkopilottia Sundom Smart Gridiä simuloimalla. Simuloinnit tehtiin sekä lyhyen aikavälin offline-simulaatio-ohjelmistoilla että pitkän aikavälin simulaatioilla hyödyntäen reaaliaikasimulointilaitteistoa. Pitkän aikavälin simulaatioissa akun ikääntymisen vaikutus otettiin huomioon litiumioniakun ohjauksen suunnittelussa jotta sen vaikutusta sähköjärjestelmän kokonaistoimintaan voitiin analysoida. Tätä tarkoitusta varten luotiin akun ikääntymismalleja, joilla on mahdollista määrittää akun huipputehon muutos sen ikääntyessä. Akun huipputehon muutos taas vaikuttaa sen hyödynnettävyyteen erilaisten pätötehon ohjaukseen perustuvien joustopalveluiden tarjoamiseen liittyen. Lisäksi väitöstutkimuksessa tarkasteltiin akkujen ikääntymisen vaikutusta niiden taloudelliseen kannattavuuteen sisällyttämällä akkujen ikääntymismalleja teknis-taloudellisiin tarkasteluihin.fi=vertaisarvioitu|en=peerReviewed
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