Genetically Determined Plasma Lipid Levels and Risk of Diabetic Retinopathy: A Mendelian Randomization Study.

Results from observational studies examining dyslipidemia as a risk factor for diabetic retinopathy (DR) have been inconsistent. We evaluated the causal relationship between plasma lipids and DR using a Mendelian randomization approach. We pooled genome-wide association studies summary statistics from 18 studies for two DR phenotypes: any DR (N = 2,969 case and 4,096 control subjects) and severe DR (N = 1,277 case and 3,980 control subjects). Previously identified lipid-associated single nucleotide polymorphisms served as instrumental variables. Meta-analysis to combine the Mendelian randomization estimates from different cohorts was conducted. There was no statistically significant change in odds ratios of having any DR or severe DR for any of the lipid fractions in the primary analysis that used single nucleotide polymorphisms that did not have a pleiotropic effect on another lipid fraction. Similarly, there was no significant association in the Caucasian and Chinese subgroup analyses. This study did not show evidence of a causal role of the four lipid fractions on DR. However, the study had limited power to detect odds ratios less than 1.23 per SD in genetically induced increase in plasma lipid levels, thus we cannot exclude that causal relationships with more modest effect sizes exist

Heterogeneity of diabetes outcomes among asians and pacific islanders in the US: the diabetes study of northern california (DISTANCE).

ObjectiveEthnic minorities with diabetes typically have lower rates of cardiovascular outcomes and higher rates of end-stage renal disease (ESRD) compared with whites. Diabetes outcomes among Asian and Pacific Islander subgroups have not been disaggregated.Research design and methodsWe performed a prospective cohort study (1996-2006) of patients enrolled in the Kaiser Permanente Northern California Diabetes Registry. There were 64,211 diabetic patients, including whites (n = 40,286), blacks (n = 8,668), Latinos (n = 7,763), Filipinos (n = 3,572), Chinese (n = 1,823), Japanese (n = 951), Pacific Islanders (n = 593), and South Asians (n = 555), enrolled in the registry. We calculated incidence rates (means ± SD; 7.2 ± 3.3 years follow-up) and created Cox proportional hazards models adjusted for age, educational attainment, English proficiency, neighborhood deprivation, BMI, smoking, alcohol use, exercise, medication adherence, type and duration of diabetes, HbA(1c), hypertension, estimated glomerular filtration rate, albuminuria, and LDL cholesterol. Incidence of myocardial infarction (MI), congestive heart failure, stroke, ESRD, and lower-extremity amputation (LEA) were age and sex adjusted.ResultsPacific Islander women had the highest incidence of MI, whereas other ethnicities had significantly lower rates of MI than whites. Most nonwhite groups had higher rates of ESRD than whites. Asians had ~60% lower incidence of LEA compared with whites, African Americans, or Pacific Islanders. Incidence rates in Chinese, Japanese, and Filipinos were similar for most complications. For the three macrovascular complications, Pacific Islanders and South Asians had rates similar to whites.ConclusionsIncidence of complications varied dramatically among the Asian subgroups and highlights the value of a more nuanced ethnic stratification for public health surveillance and etiologic research

Study on TCM Syndrome Identification Modes of Coronary Heart Disease Based on Data Mining

Coronary heart disease (CHD) is one of the most important types of heart disease because of its high incidence and high mortality. TCM has played an important role in the treatment of CHD. Syndrome differentiation based on information from traditional four diagnostic methods has met challenges and questions with the rapid development and wide application of system biology. In this paper, methods of complex network and CHAID decision tree were applied to identify the TCM core syndromes of patients with CHD, and to establish TCM syndrome identification modes of CHD based on biological parameters. At the same time, external validation modes were also constructed to confirm the identification modes

Can external use of Chinese herbal medicine prevent cumulative peripheral neuropathy induced oxaliplatin? : a systematic literature review with meta-analysis

Background. Peripheral neurotoxicity caused by oxaliplatin (OXA) chemotherapy is the main limitation preventing continuation of chemotherapy in patients with gastrointestinal cancer. The purpose of this study was to determine the efficacy of external use of Chinese herbal medicine (CHM) on the incidence of cumulative OXA-induced peripheral neurotoxicity (OIPN). Method. Scientific literature databases were searched to identify controlled clinical trials analyzing CHM in OIPN. Clinical studies that included at least 1 relevant primary outcome were analyzed by 2 independent reviewers. Meta-analysis was performed on the software RevMan 5.3. Results. 700 cancer patients of 9 studies were reported, of whom 352 received external CHM and 348 received warm water baths, conventional medicine, or no intervention as controls. Neurotoxicity incidence (Levi grade ≥ 1) was significantly decreased in CHM group, compared with no intervention (P .05). Conclusion. External use of CHM may be beneficial in preventing the OXA-induced cumulative neurotoxicity. However, given the low quality of the evidence, the results should be interpreted with caution

Repeatability of facial soft tissue thickness measurements for forensic facial reconstruction using X-ray images

The repeatability of facial soft tissue thickness measurements at 10 standard anatomical landmarks was evaluated using lateral X-ray images obtained from 50 adult subjects. The intra-and inter-observer error rates were calculated after four practitioners took measurements using Denta Pacs 8.1 software. The results indicated high inter- and intra-observer repeatability, suggesting X-ray images can be used to measure facial soft tissue thicknesses for the purpose of craniofacial reconstruction and superimposition

Does gender moderate associations between social capital and smoking? An Asian American study

Growing research finds that social capital is associated with smoking. However, most studies focus on white populations and do not take into account potential differences between genders. The present study examines the associations between social capital and self-report smoking status and assesses the moderating role of gender among a national representative sample of Asian American adults. Social capital consisted of measures of individual social connectedness (i.e. social ties with relatives and friends) and subjective evaluation of family and neighborhood environment (i.e. family and neighborhood cohesion, family conflict). Asian men were almost three times more likely to be current smokers than women (20.1% vs. 7.0%). Results of multivariate logistic regression analyses showed that family conflicts or higher levels of connectedness with family members were associated with increased odds of being a current smoker among Asian Americans as a whole. Further stratified analysis revealed significant gender differences in several aspects of social capital: there were stronger effects of social connectedness with family members on increasing the odds of smoking for women than for men. In addition, women who had closer connections to friends had greater odds of being current smokers, whereas the opposite was true for men. The findings of this study provide new evidence for the differential effects of social capital by gender, suggesting that more studies are needed to understand social capital’s effects in different racial/ethnic populations and the mechanisms by which the effects vary with gender.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374585/Accepted manuscrip

Beauty and Health: Anthropological Perspectives

This essay, written as a 'teaser' for an up-coming symposium, reflects on how human beauty can be understood from an anthropological and medical anthropological perspective. First, it considers how aesthetic and healing rationales can conflict or merge in a variety of medical technologies and health practices. Second, it discusses beauty in relation to the socioeconomic transformations of modernity and globalization. It suggests the need for a theoretical framework that departs from a strictly constructivist approach and views beauty as a distinct domain of social experience, not reducible to an effect of other inequalities