50 research outputs found

    Insulin Estimation and Prediction A REVIEW OF THE ESTIMATION AND PREDICTION OF SUBCUTANEOUS INSULIN PHARMACOKINETICS IN CLOSED-LOOP GLUCOSE CONTROL

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    This work was supported by the Spanish Ministry of Economy and Competitiveness (MINECO) through grant DPI2013-46982-C2-1-R and the EU through FEDER funds.Bondía Company, J.; Romero Vivó, S.; Ricarte Benedito, B.; Diez, J. (2018). Insulin Estimation and Prediction A REVIEW OF THE ESTIMATION AND PREDICTION OF SUBCUTANEOUS INSULIN PHARMACOKINETICS IN CLOSED-LOOP GLUCOSE CONTROL. IEEE Control Systems. 38(1):47-66. https://doi.org/10.1109/MCS.2017.2766312S476638

    Real-time detection of auditory : steady-state brainstem potentials evoked by auditory stimuli

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    The auditory steady-state response (ASSR) is advantageous against other hearing techniques because of its capability in providing objective and frequency specific information. The objectives are to reduce the lengthy test duration, and improve the signal detection rate and the robustness of the detection against the background noise and unwanted artefacts.Two prominent state estimation techniques of Luenberger observer and Kalman filter have been used in the development of the autonomous ASSR detection scheme. Both techniques are real-time implementable, while the challenges faced in the application of the observer and Kalman filter techniques are the very poor SNR (could be as low as −30dB) of ASSRs and unknown statistics of the noise. Dual-channel architecture is proposed, one is for the estimate of sinusoid and the other for the estimate of the background noise. Simulation and experimental studies were also conducted to evaluate the performances of the developed ASSR detection scheme, and to compare the new method with other conventional techniques. In general, both the state estimation techniques within the detection scheme produced comparable results as compared to the conventional techniques, but achieved significant measurement time reduction in some cases. A guide is given for the determination of the observer gains, while an adaptive algorithm has been used for adjustment of the gains in the Kalman filters.In order to enhance the robustness of the ASSR detection scheme with adaptive Kalman filters against possible artefacts (outliers), a multisensory data fusion approach is used to combine both standard mean operation and median operation in the ASSR detection algorithm. In addition, a self-tuned statistical-based thresholding using the regression technique is applied in the autonomous ASSR detection scheme. The scheme with adaptive Kalman filters is capable of estimating the variances of system and background noise to improve the ASSR detection rate

    Novel Strategies to design Controllers and State Predictors based on Disturbance Observers

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    [ES] Los sistemas de ingeniería o físicos suelen ser inciertos. Su incertidumbre se manifiesta cuando el sistema muestra comportamientos que son relativamente diferentes a los que su modelo predice; estando principalmente causada por: errores de modelado; dinámicas desconocidas; cambios en las propiedades del sistema; interacciones aleatorias con otros sistemas; o cambios en las condiciones de operación. Durante los últimos 40 años, se ha demostrado reiteradamente que las incertidumbres de los sistemas pueden tener efectos muy negativos sobre el comportamiento de un controlador si éstas no se consideran adecuadamente sus formulaciones matemáticas. Por esta razón, una parte importante de la investigación actual está centrada en este tema; buscando las formas mas adecuadas para representar matemáticamente las incertidumbres de los sistemas, así como buscando nuevas herramientas matemáticas que permitan hacer uso de ésta representación de la incertidumbre con el objetivo de diseñar algoritmos de control robustos. En esta tesis se presentan nuevas aportaciones en esta línea. Concretamente, se desarrollan nuevas metodologías para diseñar controladores (DOBCs) y predictores (DOBPs) para sistemas dinámicos inciertos basados en observadores de perturbaciones. La principal aportación es demostrar que los DOBCs se pueden sintetizar desde un enfoque de control óptimo; siendo su principal criterio de diseño el de aproximar la -irrealizable- señal de control óptima que minimiza un índice de coste cuadrático sujeto a un modelo dinámico lineal (LTI). Este nuevo enfoque de diseño es indistintamente válido para modelos SISO/MIMO con múltiples o únicas perturbaciones. Además permite un ajuste del controlador muy intuitivo gracias a las matrices de ponderación del coste. De forma similar; los DOBPs se construyen con el objetivo de aproximar la solución temporal un sistema dinámico perturbado. Con el objetivo de contextualizar la aportación, el documento también incluye un breve resumen de los principales métodos de control robusto y el impacto que han tenido en la revolución tecnológica del siglo XXI; algunas discusiones sobre la utilidad de los modelos LTI perturbados para representar sistemas dinámicos inciertos; y algunas relaciones, comparaciones y simulaciones numéricas de los métodos propuestos con otras técnicas de control.[CA] Els sistemes d'enginyeria o físics solen ser incerts. La seua incertesa es manifesta quan el sistema mostra comportaments que són relativament diferents als que el seu model prediu; sent principalment causada per: errors de modelatge; dinàmiques desconegudes; canvis en les propietats del sistema; interaccions aleatòries amb altres sistemes; o canvis en les condicions d'operació. Durant els últims 40 anys, s'ha demostrat reiteradament que les incerteses dels sistemes poden tindre efectes molt negatius sobre el comportament d'un controlador si aquestes no es consideren adequadament les seues formulacions matemàtiques. Per aquesta raó, una part important de la investigació actual està centrada en aquest tema; buscant les formes mes adequades per a representar matemàticament les incerteses dels sistemes, així com buscant noves tècniques matemàtiques que permeten fer ús d'aquesta representació de la incertesa amb l'objectiu de dissenyar algorismes de control robustos. En aquesta tesi es presenten noves aportacions en aquesta línia. Concretament, es desenvolupen noves metodologies per a dissenyar controladors (DOBCs) i predictors (DOBPs) per a sistemes dinàmics incerts basats en observadors de pertorbacions. La principal aportació és demostrar que els DOBCs es poden sintetitzar des d'un punt de vista de control òptim; sent el seu principal criteri de disseny el d'aproximar la -irrealitzable- senyal de control òptima que minimitza un índex de cost quadràtic restringit a un model dinàmic lineal (LTI). Aquest nou plantejament és indistintament vàlid per a models SISO/MIMO amb múltiples o úniques pertorbacions. A més permet un ajust del controlador molt intuïtiu gràcies a les matrius de ponderació del cost. De manera similar; els DOBPs es construeixen amb l'objectiu d'aproximar la solució temporal un sistema dinàmic pertorbat. Amb l'objectiu de contextualitzar l'aportació, el document també inclou un breu resum dels principals mètodes de control robust i l'impacte que han tingut en la revolució tecnològica del segle XXI; algunes discussions sobre la utilitat dels models LTI pertorbats per a representar sistemes dinàmics incerts; i algunes relacions, comparacions i simulacions numèriques dels mètodes proposats amb altres tècniques de control.[EN] Engineering or physical systems are used to be uncertain. Its uncertainty is manifested whenever the system shows behaviors that are relatively different than the ones predicted by its model; being mostly caused by: modeling errors; unknown dynamics; changes in the system properties; random interactions with other systems; or changes in the operating conditions. Through the last 40 years, it has been persistently proved that the system uncertainties could have very negative effects in the performance of a feedback regulator if they are not properly considered in the mathematical formulations of the employed algorithms. Thus, an important part of the recent research is focused on this topic; searching for the most appropriate ways to mathematically represent the system uncertainties and looking for new mathematical-tools that permit to make use of such uncertainty-representation in order to design robust control algorithms. In this thesis, new contributions in this line are provided. Concretely, novel methodologies to design Disturbance Observer-Based Controllers (DOBCs) and Predictors (DOBPs) for uncertain dynamic systems are developed. The main contribution is to show that the DOBCs can be constructed from an optimality-based approach, with the main objective of approximating the -unrealizable- optimal control signal that minimizes a quadratic-cost performance index subject to a LTI disturbed model constraint. This novel robust control design is indistinctly valid for SISO/MIMO models with single/multiple matched/mismatched disturbances; offering also a highly intuitive and versatile tuning through the weighting matrices. Similarly, the DOBPs are synthesized in order to approximate the time-domain solution of LTI disturbed models. For the sake of completeness, the document also includes a brief review of the main robust control methods and the impact that they have had on the technological revolution of the 21st century; some discussions about the usefulness of the LTI disturbed models for representing uncertain dynamic systems; and different relationships, comparisons and numerical simulations, of the proposed methods with other control approaches.Castillo Frasquet, A. (2021). Novel Strategies to design Controllers and State Predictors based on Disturbance Observers [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/165034TESI

    Development of monitoring and control systems for biotechnological processes

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    The field of biotechnology represents an important research area that has gained increasing success in recent times. Characterized by the involvement of biological organisms in manufacturing processes, its areas of application are broad and include the pharmaceuticals, agri-food, energy, and even waste treatment. The implication of living microorganisms represents the common element in all bioprocesses. Cell cultivations is undoubtedly the key step that requires maintaining environmental conditions in precise and defined ranges, having a significant impact on the process yield and thus on the desired product quality. The apparatus in which this process occurs is the bioreactor. Unfortunately, monitoring and controlling these processes can be a challenging task because of the complexity of the cell growth phenomenon and the limited number of variables can be monitored in real-time. The thesis presented here focuses on the monitoring and control of biotechnological processes, more specifically in the production of bioethanol by fermentation of sugars using yeasts. The study conducted addresses several issues related to the monitoring and control of the bioreactor, in which the fermentation takes place. First, the topic concerning the lack of proper sensors capable of providing online measurements of key variables (biomass, substrate, product) is investigated. For this purpose, nonlinear estimation techniques are analyzed to reconstruct unmeasurable states. In particular, the geometric observer approach is applied to select the best estimation structure and then a comparison with the extended Kalman filter is reported. Both estimators proposed demonstrate good estimation capabilities as input model parameters vary. Guaranteeing the achievement of the desired ethanol composition is the main goal of bioreactor control. To this end, different control strategies, evaluated for three different scenarios, are analzyed. The results show that the MIMO system, together with an estimator for ethanol composition, ensure the compliance with product quality. After analyzing these difficulties through numeric simulations, this research work shifts to testing a specific biotechnological process such as manufacturing bioethanol from brewery’s spent grain (BSG) as renewable waste biomass. Both acid pre-treatment, which is necessary to release sugars, and fermentation are optimized. Results show that a glucose yield of 18.12 per 100 g of dried biomass is obtained when the pre-treatment step is performed under optimized conditions (0.37 M H2SO4, 10% S-L ratio). Regarding the fermentation, T=25°C, pH=4.5, and inoculum volume equal to 12.25% v/v are selected as the best condition, at which an ethanol yield of 82.67% evaluated with respect to theoretical one is obtained. As a final step, the use of Raman spectroscopy combined with chemometric techniques such as Partial Least Square (PLS) analysis is evaluated to develop an online sensor for fermentation process monitoring. The results show that the biomass type involved significantly affects the acquired spectra, making them noisy and difficult to interpret. This represents a nontrivial limitation of the applied methodology, for which more experimental data and more robust statistical techniques could be helpful

    Simultaneous Nonlinear Model Predictive Control and State Estimation: Theory and Applications

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    As computational power increases, online optimization is becoming a ubiquitous approach for solving control and estimation problems in both academia and industry. This widespread popularity of online optimization techniques is largely due to their abilities to solve complex problems in real time and to explicitly accommodate hard constraints. In this dissertation, we discuss an especially popular online optimization control technique called model predictive control (MPC). Specifically, we present a novel output-feedback approach to nonlinear MPC, which combines the problems of state estimation and control into a single min-max optimization. In this way, the control and estimation problems are solved simultaneously providing an output-feedback controller that is robust to worst-case system disturbances and noise. This min-max optimization is subject to the nonlinear system dynamics as well as constraints that come from practical considerations such as actuator limits. Furthermore, we introduce a novel primal-dual interior-point method that can be used to efficiently solve the min-max optimization problem numerically and present several examples showing that the method succeeds even for severely nonlinear and non-convex problems. Unlike other output-feedback nonlinear optimal control approaches that solve the estimation and control problems separately, this combined estimation and control approach facilitates straightforward analysis of the resulting constrained, nonlinear, closed-loop system and yields improved performance over other standard approaches. Under appropriate assumptions that encode controllability and observability of the nonlinear process to be controlled, we show that this approach ensures that the state of the closed-loop system remains bounded. Finally, we investigate the use of this approach in several applications including the coordination of multiple unmanned aerial vehicles for vision-based target tracking of a moving ground vehicle and feedback control of an artificial pancreas system for the treatment of Type 1 Diabetes. We discuss why this novel combined control and estimation approach is especially beneficial for these applications and show promising simulation results for the eventual implementation of this approach in real-life scenarios

    Disturbance Suppression in PMSM Drives Physical Investigation, Algorithm Design and Implementation

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    The work of this Ph.D. focuses on the investigation of advanced control algorithms for the control of constant and periodic disturbances in Permanent Magnet Synchronous Machines (PMSMs), with the discussion of different methods for improving their negative influence on the machine current and the torque produced at the shaft. The discussion of the disturbances from a control perspective starts with the study of the parameter uncertainties effect on the dynamical performances of the current control and after the detailed analysis in the frequency domain, simple methods for improving the state-of-art decoupling network are given and validated on the testbench. Thanks to the feature of the introduced estimator, the transient behavior of the proposed strategy results in a consistent fast and precise performance. The control scheme allows to avoid the implementation of anti-windup mechanisms in the current control, making the overall controller less sensitive to parameter mismatch. Further, due to the low computational burden, the algorithm is suitable for low cost hardware. Subsequently, the more complex issue of periodic disturbances has been deeply investigated. The theoretical model proposed is validated by comparing the real measured torque with an estimation based on the recovered disturbance affecting the observed voltages and currents. The results are clearly acceptable and further, the experimental validation stresses out the fact that few terms have a predominant role in producing the harmonic disturbances, compared to the others. This consideration lets develop two strategies for suppressing the different harmonic orders present in the machine torque at low-speed operation. One strategy relies on on-line adaptive policies, where the estimated information is passed through a sequence of optimization algorithms with different objectives. In this context, hints on the guaranteed stability are also provided in order to confirm the practical feasibility of the algorithm. The other strategy is based on the off-line generation of some pre-determined functions, limiting the on-line burden to the computation of look-up tables. Both methods brought satisfactory results during the experimental validation, confirming the validity of our approximations made on the original complex model. Although the hardware testbed setup limited the opportunity to validate the methodologies at low speed, this represents a realistic scenario, in fact at higher speed the artificial injection of harmonics within the machine current becomes challenging due to the high electrical rotational speed and it brings more negative effects, in terms of losses and audible noise than benefits on the shaft stress, in fact, the machine inertia acts as a natural filter for the high frequencies harmonics. In summary, it can be said that the research work on advanced control algorithms for the disturbance suppression in PMSM drives has produced affordable and reliable methodologies, which can be of practical implementation for various industrial drives
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