Rade, Development, and the Broken Promise of Interdependence: A Buddhist Reflection on the Possibility of Post-market Economics

Bhutan's stated intention of keeping the value of happiness central to the development process is a suitable counter to the values and karma that prevail in most development strategies and ideals. Given present day realities of unprecedented, accelerating changes and paradigmatic shifts in economic, political, and social practices, any successful strategy for integration into global development processes must be creative in nature. It must, in other words, consist of an ongoing improvisation that is at once virtuosic and virtuous and that brings both greater resolution and resolve into the development process. In this essay the author wants to contribute to this effort by considering the broad landscape of development and trade concepts and practices and their implications for the trajectory of innovations needed to insure that development processes and greater economic interdependence are, indeed, liberating. The auhtor starts by reflecting on the context of present day patterns of development, raising some issues related to history and scale in assessing the effects of increasing global interdependence. He suggestes that present day patterns and scales of globalization have both generated and been generated by the extremely rapid and practically irreversible commodification of subsistence needs—a commodification that (paraphrasing Ivan Illich) has the effect of institutionalizing entirely new classes of the poor. Beyond a critical threshold and unless redirected—that is, informed by radically different values—present day patterns of interdependence will continue bringing about the conversion of communities that have been faring well into aggregates of individuals in need of welfare. Unchecked, the promise of globally extended, deep community will be broken

This Time It's Personal: from PIM to the Perfect Digital Assistant

Interacting with digital PIM tools like calendars, to-do lists, address books, bookmarks and so on, is a highly manual, often repetitive and frequently tedious process. Despite increases in memory and processor power over the past two decades of personal computing, not much has changed in the way we engage with such applications. We must still manually decompose frequently performed tasks into multiple smaller, data specific processes if we want to be able to recall or reuse the information in some meaningful way. "Meeting with Yves at 5 in Stata about blah" breaks down into rigid, fixed semantics in separate applications: data to be recorded in calendar fields, address book fields and, as for the blah, something that does not necessarily exist as a PIM application data structure. We argue that a reason Personal Information Management tools may be so manual, and so effectively fragmented, is that they are not personal enough. If our information systems were more personal, that is, if they knew in a manner similar to the way a personal assistant would know us and support us, then our tools would be more helpful: an assistive PIM tool would gather together the necessary material in support of our meeting with Yves. We, therefore, have been investigating the possible paths towards PIM tools as tools that work for us, rather than tools that seemingly make us work for them. To that end, in the following sections we consider how we may develop a framework for PIM tools as "perfect digital assistants" (PDA). Our impetus has been to explore how, by considering the affordances of a Real World personal assistant, we can conceptualize a design framework, and from there a development program for a digital simulacrum of such an assistant that is not for some far off future, but for the much nearer term

Introduction to the Old Testament: a liberation perspective

Title: Introduction to the Old Testament: a liberation perspective. Author: Ceresko, Anthony R Introduction to the Old Testament xxi, 384 p. Publisher: Maryknoll, NY : Orbis Bks, 2001. Rev ed

A structural basis for IκB kinase 2 activation via oligomerization-dependent trans auto-phosphorylation.

Activation of the IκB kinase (IKK) is central to NF-κB signaling. However, the precise activation mechanism by which catalytic IKK subunits gain the ability to induce NF-κB transcriptional activity is not well understood. Here we report a 4 Å x-ray crystal structure of human IKK2 (hIKK2) in its catalytically active conformation. The hIKK2 domain architecture closely resembles that of Xenopus IKK2 (xIKK2). However, whereas inactivated xIKK2 displays a closed dimeric structure, hIKK2 dimers adopt open conformations that permit higher order oligomerization within the crystal. Reversible oligomerization of hIKK2 dimers is observed in solution. Mutagenesis confirms that two of the surfaces that mediate oligomerization within the crystal are also critical for the process of hIKK2 activation in cells. We propose that IKK2 dimers transiently associate with one another through these interaction surfaces to promote trans auto-phosphorylation as part of their mechanism of activation. This structure-based model supports recently published structural data that implicate strand exchange as part of a mechanism for IKK2 activation via trans auto-phosphorylation. Moreover, oligomerization through the interfaces identified in this study and subsequent trans auto-phosphorylation account for the rapid amplification of IKK2 phosphorylation observed even in the absence of any upstream kinase

Clustering and Micro-immiscibility in Alcohol-Water Mixtures: Evidence from Molecular Dynamics Simulations

We have investigated the hydrogen-bonded structures in liquid methanol and a 7:3 mole fraction aqueous solution using classical Molecular Dynamics simulations at 298K and ambient pressure. We find that, in contrast to recent predictions from X-ray emission studies, the hydrogen-bonded structure in liquid methanol is dominated by chain and small ring structures. In the methanol-rich solution, we find evidence of micro-immiscibility, supporting recent conclusions derived from neutron diffraction data.Comment: 5 pages, 4 figure

Tension and challenge in collaborative school-university research.

Collaborative university and school research projects are inevitably labour intensive endeavours that require the careful negotiation of trust and the joint critique of current practice. While this raises tension it can also build generative communities of inquiry that enhance both theory and practice. This article refers to an arts project undertaken in eight primary schools between university staff and generalist teacher co-researchers, focusing on children's idea development in dance, drama, music and visual art. The two-year project is briefly outlined and some issues that arise in school research are explored. There were issues related to insider-outsider tensions, the familiarity all project members have with classrooms, and the associated difficulties with reconceptualising how things might be done. While there are many strengths in collaborative research, there are also tensions. Some of the tensions outlined in this paper include: the need to exercise healthy scepticism alongside interest in the arts; the different cultures of schools and universities and how these influence research; and issues of risk and trust, which are both sensitive areas of ongoing negotiation. These issues and paradoxes in collaborative research are considered alongside particular processes that build school and university partnerships