An Introduction to MPEG-G: The First Open ISO/IEC Standard for the Compression and Exchange of Genomic Sequencing Data

The development and progress of high-throughput sequencing technologies have transformed the sequencing of DNA from a scientific research challenge to practice. With the release of the latest generation of sequencing machines, the cost of sequencing a whole human genome has dropped to less than 600. Such achievements open the door to personalized medicine, where it is expected that genomic information of patients will be analyzed as a standard practice. However, the associated costs, related to storing, transmitting, and processing the large volumes of data, are already comparable to the costs of sequencing. To support the design of new and interoperable solutions for the representation, compression, and management of genomic sequencing data, the Moving Picture Experts Group (MPEG) jointly with working group 5 of ISO/TC276 'Biotechnology' has started to produce the ISO/IEC 23092 series, known as MPEG-G. MPEG-G does not only offer higher levels of compression compared with the state of the art but it also provides new functionalities, such as built-in support for random access in the compressed domain, support for data protection mechanisms, flexible storage, and streaming capabilities. MPEG-G only specifies the decoding syntax of compressed bitstreams, as well as a file format and a transport format. This allows for the development of new encoding solutions with higher degrees of optimization while maintaining compatibility with any existing MPEG-G decoder

Energy efficient enabling technologies for semantic video processing on mobile devices

Semantic object-based processing will play an increasingly important role in future multimedia systems due to the ubiquity of digital multimedia capture/playback technologies and increasing storage capacity. Although the object based paradigm has many undeniable benefits, numerous technical challenges remain before the applications becomes pervasive, particularly on computational constrained mobile devices. A fundamental issue is the ill-posed problem of semantic object segmentation. Furthermore, on battery powered mobile computing devices, the additional algorithmic complexity of semantic object based processing compared to conventional video processing is highly undesirable both from a real-time operation and battery life perspective. This thesis attempts to tackle these issues by firstly constraining the solution space and focusing on the human face as a primary semantic concept of use to users of mobile devices. A novel face detection algorithm is proposed, which from the outset was designed to be amenable to be offloaded from the host microprocessor to dedicated hardware, thereby providing real-time performance and reducing power consumption. The algorithm uses an Artificial Neural Network (ANN), whose topology and weights are evolved via a genetic algorithm (GA). The computational burden of the ANN evaluation is offloaded to a dedicated hardware accelerator, which is capable of processing any evolved network topology. Efficient arithmetic circuitry, which leverages modified Booth recoding, column compressors and carry save adders, is adopted throughout the design. To tackle the increased computational costs associated with object tracking or object based shape encoding, a novel energy efficient binary motion estimation architecture is proposed. Energy is reduced in the proposed motion estimation architecture by minimising the redundant operations inherent in the binary data. Both architectures are shown to compare favourable with the relevant prior art