291 research outputs found
Learning-based 3T brain MRI segmentation with guidance from 7T MRI labeling: Learning-based 3T brain MRI segmentation
Segmentation of brain magnetic resonance (MR) images into white matter (WM), gray matter (GM), and cerebrospinal fluid (CSF) is crucial for brain structural measurement and disease diagnosis. Learning-based segmentation methods depend largely on the availability of good training ground truth. However, the commonly used 3T MR images are of insufficient image quality and often exhibit poor intensity contrast between WM, GM, and CSF. Therefore, they are not ideal for providing good ground truth label data for training learning-based methods. Recent advances in ultrahigh field 7T imaging make it possible to acquire images with excellent intensity contrast and signal-to-noise ratio
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Development of Deep Learning Methods for Magnetic Resonance Phase Imaging of Neurological Disease
Magnetic resonance imaging (MRI) is a high-resolution, non-invasive medical imaging modality that is widely used in human brain. In recent years, susceptibility weighted imaging (SWI) and quantitative susceptibility mapping (QSM) have been proposed to utilize MR phase signal to generate contrast from tissue magnetic susceptibility and even quantify the property. On the other hand, deep learning, especially deep convolutional neural networks (DCNNs), have achieved state-of-the-art performances in numerous computer vision tasks and gained significant attention in the field of medical imaging in the recent years. This dissertation combined the idea of deep learning with the two MR phase imaging methods. To combined deep learning with SWI, we designed and trained a 3D deep residual network that can distinguish false positive detected candidates from cerebral microbleeds (CMBs) and built an automatic CMB detection pipeline with high performance. We further confirmed the generalizability of this deep learning-based pipeline using multiple dataset with different scan parameters and pathologies and provided lessons for application and generalization of generic deep learning based medical imaging methods.To combine deep learning with QSM, we developed a 3D U-Net based network that learns to perform dipole inversion from gold standard QSM acquired from data with multiple orientation. The model was further improved with adversarial training strategy and achieved significantly lower reconstruction error than traditional QSM algorithms. In addition, we also performed various background removal and dipole inversion algorithms on both brain tumor patients and healthy volunteers to study and compare their performances. The results could provide guidance on future application of QSM in different scenarios
Restauration d'images en IRM anatomique pour l'étude préclinique des marqueurs du vieillissement cérébral
Les maladies neurovasculaires et neurodégénératives liées à l'âge sont en forte augmentation. Alors que ces changements pathologiques montrent des effets sur le cerveau avant l'apparition de symptômes cliniques, une meilleure compréhension du processus de vieillissement normal du cerveau aidera à distinguer l'impact des pathologies connues sur la structure régionale du cerveau. En outre, la connaissance des schémas de rétrécissement du cerveau dans le vieillissement normal pourrait conduire à une meilleure compréhension de ses causes et peut-être à des interventions réduisant la perte de fonctions cérébrales associée à l'atrophie cérébrale. Par conséquent, ce projet de thèse vise à détecter les biomarqueurs du vieillissement normal et pathologique du cerveau dans un modèle de primate non humain, le singe marmouset (Callithrix Jacchus), qui possède des caractéristiques anatomiques plus proches de celles des humains que de celles des rongeurs. Cependant, les changements structurels (par exemple, de volumes, d'épaisseur corticale) qui peuvent se produire au cours de leur vie adulte peuvent être minimes à l'échelle de l'observation. Dans ce contexte, il est essentiel de disposer de techniques d'observation offrant un contraste et une résolution spatiale suffisamment élevés et permettant des évaluations détaillées des changements morphométriques du cerveau associé au vieillissement. Cependant, l'imagerie de petits cerveaux dans une plateforme IRM 3T dédiée à l'homme est une tâche difficile car la résolution spatiale et le contraste obtenus sont insuffisants par rapport à la taille des structures anatomiques observées et à l'échelle des modifications attendues. Cette thèse vise à développer des méthodes de restauration d'image pour les images IRM précliniques qui amélioreront la robustesse des algorithmes de segmentation. L'amélioration de la résolution spatiale des images à un rapport signal/bruit constant limitera les effets de volume partiel dans les voxels situés à la frontière entre deux structures et permettra une meilleure segmentation tout en augmentant la reproductibilité des résultats. Cette étape d'imagerie computationnelle est cruciale pour une analyse morphométrique longitudinale fiable basée sur les voxels et l'identification de marqueurs anatomiques du vieillissement cérébral en suivant les changements de volume dans la matière grise, la matière blanche et le liquide cérébral.Age-related neurovascular and neurodegenerative diseases are increasing significantly. While such pathological changes show effects on the brain before clinical symptoms appear, a better understanding of the normal aging brain process will help distinguish known pathologies' impact on regional brain structure. Furthermore, knowledge of the patterns of brain shrinkage in normal aging could lead to a better understanding of its causes and perhaps to interventions reducing the loss of brain functions. Therefore, this thesis project aims to detect normal and pathological brain aging biomarkers in a non-human primate model, the marmoset monkey (Callithrix Jacchus) which possesses anatomical characteristics more similar to humans than rodents. However, structural changes (e.g., volumes, cortical thickness) that may occur during their adult life may be minimal with respect to the scale of observation. In this context, it is essential to have observation techniques that offer sufficiently high contrast and spatial resolution and allow detailed assessments of the morphometric brain changes associated with aging. However, imaging small brains in a 3T MRI platform dedicated to humans is a challenging task because the spatial resolution and the contrast obtained are insufficient compared to the size of the anatomical structures observed and the scale of the xpected changes with age. This thesis aims to develop image restoration methods for preclinical MR images that will improve the robustness of the segmentation algorithms. Improving the resolution of the images at a constant signal-to-noise ratio will limit the effects of partial volume in voxels located at the border between two structures and allow a better segmentation while increasing the results' reproducibility. This computational imaging step is crucial for a reliable longitudinal voxel-based morphometric analysis and for the identification of anatomical markers of brain aging by following the volume changes in gray matter, white matter and cerebrospinal fluid
Seven Tesla MRI in Alzheimer's disease research: State of the art and future directions: A narrative review
Seven tesla magnetic resonance imaging (7T MRI) is known to offer a superior spatial resolution and a signal-to-noise ratio relative to any other non-invasive imaging technique and provides the possibility for neuroimaging researchers to observe disease-related structural changes, which were previously only apparent on post-mortem tissue analyses. Alzheimer's disease is a natural and widely used subject for this technology since the 7T MRI allows for the anticipation of disease progression, the evaluation of secondary prevention measures thought to modify the disease trajectory, and the identification of surrogate markers for treatment outcome. In this editorial, we discuss the various neuroimaging biomarkers for Alzheimer's disease that have been studied using 7T MRI, which include morphological alterations, molecular characterization of cerebral T2*-weighted hypointensities, the evaluation of cerebral microbleeds and microinfarcts, biochemical changes studied with MR spectroscopy, as well as some other approaches. Finally, we discuss the limitations of the 7T MRI regarding imaging Alzheimer's disease and we provide our outlook for the future
Quantitative MRI correlates of hippocampal and neocortical pathology in intractable temporal lobe epilepsy
Intractable or drug-resistant epilepsy occurs in over 30% of epilepsy patients, with many of these patients undergoing surgical excision of the affected brain region to achieve seizure control. Advances in MRI have the potential to improve surgical treatment of epilepsy through improved identification and delineation of lesions. However, validation is currently needed to investigate histopathological correlates of these new imaging techniques. The purpose of this work is to investigate histopathological correlates of quantitative relaxometry and DTI from hippocampal and neocortical specimens of intractable TLE patients. To achieve this goal I developed and evaluated a pipeline for histology to in-vivo MRI image registration, which finds dense spatial correspondence between both modalities. This protocol was divided in two steps whereby sparsely sectioned histology from temporal lobe specimens was first registered to the intermediate ex-vivo MRI which is then registered to the in-vivo MRI, completing a pipeline for histology to in-vivo MRI registration. When correlating relaxometry and DTI with neuronal density and morphology in the temporal lobe neocortex, I found T1 to be a predictor of neuronal density in the neocortical GM and demonstrated that employing multi-parametric MRI (combining T1 and FA together) provided a significantly better fit than each parameter alone in predicting density of neurons. This work was the first to relate in-vivo T1 and FA values to the proportion of neurons in GM. When investigating these quantitative multimodal parameters with histological features within the hippocampal subfields, I demonstrated that MD correlates with neuronal density and size, and can act as a marker for neuron integrity within the hippocampus. More importantly, this work was the first to highlight the potential of subfield relaxometry and diffusion parameters (mainly T2 and MD) as well as volumetry in predicting the extent of cell loss per subfield pre-operatively, with a precision so far unachievable. These results suggest that high-resolution quantitative MRI sequences could impact clinical practice for pre-operative evaluation and prediction of surgical outcomes of intractable epilepsy
Fighting the scanner effect in brain MRI segmentation with a progressive level-of-detail network trained on multi-site data
Many clinical and research studies of the human brain require an accurate
structural MRI segmentation. While traditional atlas-based methods can be
applied to volumes from any acquisition site, recent deep learning algorithms
ensure very high accuracy only when tested on data from the same sites
exploited in training (i.e., internal data). The performance degradation
experienced on external data (i.e., unseen volumes from unseen sites) is due to
the inter-site variabilities in intensity distributions induced by different MR
scanner models, acquisition parameters, and unique artefacts. To mitigate this
site-dependency, often referred to as the scanner effect, we propose LOD-Brain,
a 3D convolutional neural network with progressive levels-of-detail (LOD) able
to segment brain data from any site. Coarser network levels are responsible to
learn a robust anatomical prior useful for identifying brain structures and
their locations, while finer levels refine the model to handle site-specific
intensity distributions and anatomical variations. We ensure robustness across
sites by training the model on an unprecedented rich dataset aggregating data
from open repositories: almost 27,000 T1w volumes from around 160 acquisition
sites, at 1.5 - 3T, from a population spanning from 8 to 90 years old.
Extensive tests demonstrate that LOD-Brain produces state-of-the-art results,
with no significant difference in performance between internal and external
sites, and robust to challenging anatomical variations. Its portability opens
the way for large scale application across different healthcare institutions,
patient populations, and imaging technology manufacturers. Code, model, and
demo are available at the project website
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