A Neurorobotics Simulation of Autistic Behavior Induced by Unusual Sensory Precision

Recently, applying computational models developed in cognitive science to psychiatric disorders has been recognized as an essential approach for understanding cognitive mechanisms underlying psychiatric symptoms. Autism spectrum disorder is a neurodevelopmental disorder that is hypothesized to affect information processes in the brain involving the estimation of sensory precision (uncertainty), but the mechanism by which observed symptoms are generated from such abnormalities has not been thoroughly investigated. Using a humanoid robot controlled by a neural network using a precision-weighted prediction error minimization mechanism, it is suggested that both increased and decreased sensory precision could induce the behavioral rigidity characterized by resistance to change that is characteristic of autistic behavior. Specifically, decreased sensory precision caused any error signals to be disregarded, leading to invariability of the robot’s intention, while increased sensory precision caused an excessive response to error signals, leading to fluctuations and subsequent fixation of intention. The results may provide a system-level explanation of mechanisms underlying different types of behavioral rigidity in autism spectrum and other psychiatric disorders. In addition, our findings suggest that symptoms caused by decreased and increased sensory precision could be distinguishable by examining the internal experience of patients and neural activity coding prediction error signals in the biological brain

Fractals in the Nervous System: conceptual Implications for Theoretical Neuroscience

This essay is presented with two principal objectives in mind: first, to document the prevalence of fractals at all levels of the nervous system, giving credence to the notion of their functional relevance; and second, to draw attention to the as yet still unresolved issues of the detailed relationships among power law scaling, self-similarity, and self-organized criticality. As regards criticality, I will document that it has become a pivotal reference point in Neurodynamics. Furthermore, I will emphasize the not yet fully appreciated significance of allometric control processes. For dynamic fractals, I will assemble reasons for attributing to them the capacity to adapt task execution to contextual changes across a range of scales. The final Section consists of general reflections on the implications of the reviewed data, and identifies what appear to be issues of fundamental importance for future research in the rapidly evolving topic of this review

Neural and Behavioral Mechanisms of Interval Timing in the Striatum

To guide behavior and learn from its consequences, the brain must represent time over many scales. Yet, the neural signals used to encode time in the seconds to minute range are not known. The striatum is the major input area of the basal ganglia; it plays important roles in learning, motor function and normal timing behavior in the range of seconds to minutes. We investigated how striatal population activity might encode time. To do so, we recorded the electrical activity from striatal neurons in rats performing the serial fixed interval task, a dynamic version of the fixed Interval schedule of reinforcement. The animals performed in conformity with proportional timing, but did not strictly conform to scalar timing predictions, which might reflect a parallel strategy to optimize the adaptation to changes in temporal contingencies and consequently to improve reward rate over the session. Regarding the neural activity, we found that neurons fired at delays spanning tens of seconds and that this pattern of responding reflected the interaction between time and the animals’ ongoing sensorimotor state. Surprisingly, cells rescaled responses in time when intervals changed, indicating that striatal populations encoded relative time. Moreover, time estimates decoded from activity predicted trial-bytrial timing behavior as animals adjusted to new intervals, and disrupting striatal function with local infusion of muscimol led to a decrease in timing performance. Because of practical limitations in testing for sufficiency a biological system, we ran a simple simulation of the task; we have shown that neural responses similar to those we observe are conceptually sufficient to produce temporally adaptive behavior. Furthermore, we attempted to explain temporal processes on the basis of ongoing behavior by decoding temporal estimates from high-speed videos of the animals performing the task; we could not explain the temporal report solely on basis of ongoing behavior. These results suggest that striatal activity forms a scalable population firing rate code for time, providing timing signals that animals use to guide their actions

Shared Perception in Human-Robot Interaction

Interaction can be seen as a composition of perspectives: the integration of perceptions, intentions, and actions on the environment two or more agents share. For an interaction to be effective, each agent must be prone to “sharedness”: being situated in a common environment, able to read what others express about their perspective, and ready to adjust one’s own perspective accordingly. In this sense, effective interaction is supported by perceiving the environment jointly with others, a capability that in this research is called Shared Perception. Nonetheless, perception is a complex process that brings the observer receiving sensory inputs from the external world and interpreting them based on its own, previous experiences, predictions, and intentions. In addition, social interaction itself contributes to shaping what is perceived: others’ attention, perspective, actions, and internal states may also be incorporated into perception. Thus, Shared perception reflects the observer's ability to integrate these three sources of information: the environment, the self, and other agents. If Shared Perception is essential among humans, it is equally crucial for interaction with robots, which need social and cognitive abilities to interact with humans naturally and successfully. This research deals with Shared Perception within the context of Social Human-Robot Interaction (HRI) and involves an interdisciplinary approach. The two general axes of the thesis are the investigation of human perception while interacting with robots and the modeling of robot’s perception while interacting with humans. Such two directions are outlined through three specific Research Objectives, whose achievements represent the contribution of this work. i) The formulation of a theoretical framework of Shared Perception in HRI valid for interpreting and developing different socio-perceptual mechanisms and abilities. ii) The investigation of Shared Perception in humans focusing on the perceptual mechanism of Context Dependency, and therefore exploring how social interaction affects the use of previous experience in human spatial perception. iii) The implementation of a deep-learning model for Addressee Estimation to foster robots’ socio-perceptual skills through the awareness of others’ behavior, as suggested in the Shared Perception framework. To achieve the first Research Objective, several human socio-perceptual mechanisms are presented and interpreted in a unified account. This exposition parallels mechanisms elicited by interaction with humans and humanoid robots and aims to build a framework valid to investigate human perception in the context of HRI. Based on the thought of D. Davidson and conceived as the integration of information coming from the environment, the self, and other agents, the idea of "triangulation" expresses the critical dynamics of Shared Perception. Also, it is proposed as the functional structure to support the implementation of socio-perceptual skills in robots. This general framework serves as a reference to fulfill the other two Research Objectives, which explore specific aspects of Shared Perception. For what concerns the second Research Objective, the human perceptual mechanism of Context Dependency is investigated, for the first time, within social interaction. Human perception is based on unconscious inference, where sensory inputs integrate with prior information. This phenomenon helps in facing the uncertainty of the external world with predictions built upon previous experience. To investigate the effect of social interaction on such a mechanism, the iCub robot has been used as an experimental tool to create an interactive scenario with a controlled setting. A user study based on psychophysical methods, Bayesian modeling, and a neural network analysis of human results demonstrated that social interaction influenced Context Dependency so that when interacting with a social agent, humans rely less on their internal models and more on external stimuli. Such results are framed in Shared Perception and contribute to revealing the integration dynamics of the three sources of Shared Perception. The others’ presence and social behavior (other agents) affect the balance between sensory inputs (environment) and personal history (self) in favor of the information shared with others, that is, the environment. The third Research Objective consists of tackling the Addressee Estimation problem, i.e., understanding to whom a speaker is talking, to improve the iCub social behavior in multi-party interactions. Addressee Estimation can be considered a Shared Perception ability because it is achieved by using sensory information from the environment, internal representations of the agents’ position, and, more importantly, the understanding of others’ behavior. An architecture for Addressee Estimation is thus designed considering the integration process of Shared Perception (environment, self, other agents) and partially implemented with respect to the third element: the awareness of others’ behavior. To achieve this, a hybrid deep-learning (CNN+LSTM) model is developed to estimate the speaker-robot relative placement of the addressee based on the non-verbal behavior of the speaker. Addressee Estimation abilities based on Shared Perception dynamics are aimed at improving multi-party HRI. Making robots aware of other agents’ behavior towards the environment is the first crucial step for incorporating such information into the robot’s perception and modeling Shared Perception

Neural dynamics in cortical populations

Many essential neural computations are implemented by large populations of neurons working in concert. Recent studies have sought both to monitor increasingly large groups of neurons and to characterise their collective behaviour, but the standard computational approaches available to identify the collective dynamics scale poorly with the size of the dataset. We develop new efficient methods for discovering the low-dimensional dynamics that underlie simultaneously-recorded spike trains from a neural population. We use the new models to analyze two different sets of population recordings, one from motor cortex and another from auditory cortex. In motor cortex, we describe the nature of the trial-by-trial spontaneous fluctuations identified by the model and connect these fluctuations to behavioral events. The spatio-temporal structure of the spontaneous events was tracked by three trajectories identified by the model. These trajectories followed similar dynamics during hand reaches as they did when the hands were stationary. The structure of the models we developed allow them to be used as decoders of hand position from neural activity, significantly improving upon previous state-of-the-art methods. The decoders were able to predict information about the direction, onset time and speed profile of movements. In auditory cortex, we use the statistical models to identify population dynamics under different brain states. We report major differences in dynamics and stimulus coding between synchronized and desychronized brain states. Synchronized but not desynchronized brain states imposed constraints on neural dynamics such that a four-dimensional system accounted for most of the dynamical structure of population events. We used the low-dimensional representation of the data to construct network simulations that reproduced the patterns present in the recordings. The simulations suggest that the overall level of feedback inhibition controls the stability of each local cortical network, with unstable dynamics resulting in synchronized brain states. Finally we propose a functional role for dynamics in the representation of visual motion in visual cortex

Modelling human choices: MADeM and decision‑making

Research supported by FAPESP 2015/50122-0 and DFG-GRTK 1740/2. RP and AR are also part of the Research, Innovation and Dissemination Center for Neuromathematics FAPESP grant (2013/07699-0). RP is supported by a FAPESP scholarship (2013/25667-8). ACR is partially supported by a CNPq fellowship (grant 306251/2014-0)

Sensor fusion in distributed cortical circuits

The substantial motion of the nature is to balance, to survive, and to reach perfection. The evolution in biological systems is a key signature of this quintessence. Survival cannot be achieved without understanding the surrounding world. How can a fruit fly live without searching for food, and thereby with no form of perception that guides the behavior? The nervous system of fruit fly with hundred thousand of neurons can perform very complicated tasks that are beyond the power of an advanced supercomputer. Recently developed computing machines are made by billions of transistors and they are remarkably fast in precise calculations. But these machines are unable to perform a single task that an insect is able to do by means of thousands of neurons. The complexity of information processing and data compression in a single biological neuron and neural circuits are not comparable with that of developed today in transistors and integrated circuits. On the other hand, the style of information processing in neural systems is also very different from that of employed by microprocessors which is mostly centralized. Almost all cognitive functions are generated by a combined effort of multiple brain areas. In mammals, Cortical regions are organized hierarchically, and they are reciprocally interconnected, exchanging the information from multiple senses. This hierarchy in circuit level, also preserves the sensory world within different levels of complexity and within the scope of multiple modalities. The main behavioral advantage of that is to understand the real-world through multiple sensory systems, and thereby to provide a robust and coherent form of perception. When the quality of a sensory signal drops, the brain can alternatively employ other information pathways to handle cognitive tasks, or even to calibrate the error-prone sensory node. Mammalian brain also takes a good advantage of multimodal processing in learning and development; where one sensory system helps another sensory modality to develop. Multisensory integration is considered as one of the main factors that generates consciousness in human. Although, we still do not know where exactly the information is consolidated into a single percept, and what is the underpinning neural mechanism of this process? One straightforward hypothesis suggests that the uni-sensory signals are pooled in a ploy-sensory convergence zone, which creates a unified form of perception. But it is hard to believe that there is just one single dedicated region that realizes this functionality. Using a set of realistic neuro-computational principles, I have explored theoretically how multisensory integration can be performed within a distributed hierarchical circuit. I argued that the interaction of cortical populations can be interpreted as a specific form of relation satisfaction in which the information preserved in one neural ensemble must agree with incoming signals from connected populations according to a relation function. This relation function can be seen as a coherency function which is implicitly learnt through synaptic strength. Apart from the fact that the real world is composed of multisensory attributes, the sensory signals are subject to uncertainty. This requires a cortical mechanism to incorporate the statistical parameters of the sensory world in neural circuits and to deal with the issue of inaccuracy in perception. I argued in this thesis how the intrinsic stochasticity of neural activity enables a systematic mechanism to encode probabilistic quantities within neural circuits, e.g. reliability, prior probability. The systematic benefit of neural stochasticity is well paraphrased by the problem of Duns Scotus paradox: imagine a donkey with a deterministic brain that is exposed to two identical food rewards. This may make the animal suffer and die starving because of indecision. In this thesis, I have introduced an optimal encoding framework that can describe the probability function of a Gaussian-like random variable in a pool of Poisson neurons. Thereafter a distributed neural model is proposed that can optimally combine conditional probabilities over sensory signals, in order to compute Bayesian Multisensory Causal Inference. This process is known as a complex multisensory function in the cortex. Recently it is found that this process is performed within a distributed hierarchy in sensory cortex. Our work is amongst the first successful attempts that put a mechanistic spotlight on understanding the underlying neural mechanism of Multisensory Causal Perception in the brain, and in general the theory of decentralized multisensory integration in sensory cortex. Engineering information processing concepts in the brain and developing new computing technologies have been recently growing. Neuromorphic Engineering is a new branch that undertakes this mission. In a dedicated part of this thesis, I have proposed a Neuromorphic algorithm for event-based stereoscopic fusion. This algorithm is anchored in the idea of cooperative computing that dictates the defined epipolar and temporal constraints of the stereoscopic setup, to the neural dynamics. The performance of this algorithm is tested using a pair of silicon retinas

Sensor fusion in distributed cortical circuits

The substantial motion of the nature is to balance, to survive, and to reach perfection. The evolution in biological systems is a key signature of this quintessence. Survival cannot be achieved without understanding the surrounding world. How can a fruit fly live without searching for food, and thereby with no form of perception that guides the behavior? The nervous system of fruit fly with hundred thousand of neurons can perform very complicated tasks that are beyond the power of an advanced supercomputer. Recently developed computing machines are made by billions of transistors and they are remarkably fast in precise calculations. But these machines are unable to perform a single task that an insect is able to do by means of thousands of neurons. The complexity of information processing and data compression in a single biological neuron and neural circuits are not comparable with that of developed today in transistors and integrated circuits. On the other hand, the style of information processing in neural systems is also very different from that of employed by microprocessors which is mostly centralized. Almost all cognitive functions are generated by a combined effort of multiple brain areas. In mammals, Cortical regions are organized hierarchically, and they are reciprocally interconnected, exchanging the information from multiple senses. This hierarchy in circuit level, also preserves the sensory world within different levels of complexity and within the scope of multiple modalities. The main behavioral advantage of that is to understand the real-world through multiple sensory systems, and thereby to provide a robust and coherent form of perception. When the quality of a sensory signal drops, the brain can alternatively employ other information pathways to handle cognitive tasks, or even to calibrate the error-prone sensory node. Mammalian brain also takes a good advantage of multimodal processing in learning and development; where one sensory system helps another sensory modality to develop. Multisensory integration is considered as one of the main factors that generates consciousness in human. Although, we still do not know where exactly the information is consolidated into a single percept, and what is the underpinning neural mechanism of this process? One straightforward hypothesis suggests that the uni-sensory signals are pooled in a ploy-sensory convergence zone, which creates a unified form of perception. But it is hard to believe that there is just one single dedicated region that realizes this functionality. Using a set of realistic neuro-computational principles, I have explored theoretically how multisensory integration can be performed within a distributed hierarchical circuit. I argued that the interaction of cortical populations can be interpreted as a specific form of relation satisfaction in which the information preserved in one neural ensemble must agree with incoming signals from connected populations according to a relation function. This relation function can be seen as a coherency function which is implicitly learnt through synaptic strength. Apart from the fact that the real world is composed of multisensory attributes, the sensory signals are subject to uncertainty. This requires a cortical mechanism to incorporate the statistical parameters of the sensory world in neural circuits and to deal with the issue of inaccuracy in perception. I argued in this thesis how the intrinsic stochasticity of neural activity enables a systematic mechanism to encode probabilistic quantities within neural circuits, e.g. reliability, prior probability. The systematic benefit of neural stochasticity is well paraphrased by the problem of Duns Scotus paradox: imagine a donkey with a deterministic brain that is exposed to two identical food rewards. This may make the animal suffer and die starving because of indecision. In this thesis, I have introduced an optimal encoding framework that can describe the probability function of a Gaussian-like random variable in a pool of Poisson neurons. Thereafter a distributed neural model is proposed that can optimally combine conditional probabilities over sensory signals, in order to compute Bayesian Multisensory Causal Inference. This process is known as a complex multisensory function in the cortex. Recently it is found that this process is performed within a distributed hierarchy in sensory cortex. Our work is amongst the first successful attempts that put a mechanistic spotlight on understanding the underlying neural mechanism of Multisensory Causal Perception in the brain, and in general the theory of decentralized multisensory integration in sensory cortex. Engineering information processing concepts in the brain and developing new computing technologies have been recently growing. Neuromorphic Engineering is a new branch that undertakes this mission. In a dedicated part of this thesis, I have proposed a Neuromorphic algorithm for event-based stereoscopic fusion. This algorithm is anchored in the idea of cooperative computing that dictates the defined epipolar and temporal constraints of the stereoscopic setup, to the neural dynamics. The performance of this algorithm is tested using a pair of silicon retinas