The quest for a donor: probability based methods offer help

When a patient in need of a stem cell transplant has no compatible donor within his or her closest family, and no matched unrelated donor can be found, a remaining option is to search within the patient’s extended family. This situation often arises when the patient is of an ethnic minority, originating from a country that lacks a well-developed stem cell donor program, and has HLA haplotypes that are rare in his or her country of residence. Searching within the extended family may be time-consuming and expensive, and tools to calculate the probability of a match within groups of untested relatives would facilitate the search. We present a general approach to calculating the probability of a match in a given relative, or group of relatives, based on the pedigree, and on knowledge of the genotypes of some of the individuals. The method extends previous approaches by allowing the pedigrees to be consanguineous and arbitrarily complex, with deviations from Hardy-Weinberg equilibrium. We show how this extension has a considerable effect on results, in particular for rare haplotypes. The methods are exemplified using freeware programs to solve a case of practical importance

Structural graph matching using the EM algorithm and singular value decomposition

This paper describes an efficient algorithm for inexact graph matching. The method is purely structural, that is, it uses only the edge or connectivity structure of the graph and does not draw on node or edge attributes. We make two contributions: 1) commencing from a probability distribution for matching errors, we show how the problem of graph matching can be posed as maximum-likelihood estimation using the apparatus of the EM algorithm; and 2) we cast the recovery of correspondence matches between the graph nodes in a matrix framework. This allows one to efficiently recover correspondence matches using the singular value decomposition. We experiment with the method on both real-world and synthetic data. Here, we demonstrate that the method offers comparable performance to more computationally demanding method

Evaluation of the Performance of the Markov Blanket Bayesian Classifier Algorithm

The Markov Blanket Bayesian Classifier is a recently-proposed algorithm for construction of probabilistic classifiers. This paper presents an empirical comparison of the MBBC algorithm with three other Bayesian classifiers: Naive Bayes, Tree-Augmented Naive Bayes and a general Bayesian network. All of these are implemented using the K2 framework of Cooper and Herskovits. The classifiers are compared in terms of their performance (using simple accuracy measures and ROC curves) and speed, on a range of standard benchmark data sets. It is concluded that MBBC is competitive in terms of speed and accuracy with the other algorithms considered.Comment: 9 pages: Technical Report No. NUIG-IT-011002, Department of Information Technology, National University of Ireland, Galway (2002

Lee-Carter goes risk-neutral: an application to the Italian annuity market

We consider a class of stochastic intensities of mortality that generalizes the model proposed by Lee and Carter (1992), allowing general diffusions to drive the mortality time-trend. We analyze the stability of such class of intensities under measure changes and show how a risk-neutral version of the generalized Lee-Carter model can be employed for fair valuation purposes. We provide an example of model calibration based on the Italian annuity market