A Global Workspace perspective on mental disorders

Recent developments in Global Workspace theory suggest that human consciousness can suffer interpenetrating dysfunctions of mutual and reciprocal interaction with embedding environments which will have early onset and often insidiously staged developmental progression, possibly according to a cancer model. A simple rate distortion argument implies that, if an external information source is pathogenic, then sufficient exposure to it is sure to write a sufficiently accurate image of it on mind and body in a punctuated manner so as to initiate or promote simililarly progressively punctuated developmental disorder. There can, thus, be no simple, reductionist brain chemical 'bug in the program' whose 'fix' can fully correct the problem. On the contrary, the growth of an individual over the life course, and the inevitable contact with a toxic physical, social, or cultural environment, can be expected to initiate developmental problems which will become more intrusive over time, most obviously according to some damage accumulation model, but likely according to far more subtle, highly punctuated, schemes analogous to tumorigenesis. The key intervention, at the population level, is clearly to limit such exposures, a question of proper environmental sanitation, in a large sense, a matter of social justice which has long been understood to be determined almost entirely by the interactions of cultural trajectory, group power relations, and economic structure, with public policy. Intervention at the individual level appears limited to triggering or extending periods of remission, as is the case with most cancers

Why Do Business Service Firms Cluster? Small Consultancies, Clustering and Decentralisation in London and Southern England

Notwithstanding their remarkable recent growth, surprisingly little research has hitherto been conducted on the evolving geography of professional and business services in Britain. This paper analyses the results of a detailed survey of 300 small and medium-sized management and engineering consultancies, in investigating the forces underpinning both the striking clustering of such firms in central London and their growth in decentralised locations of East Anglia and South West England. Particular attention is paid to the role of demand-side influences, localised 'collective learning' processes, and increasing globalisation in clustering, and to so called 'enterprising behaviour theory' in explaining decentralisation.business services, clustering London, globalisation, SMEs, collective learning

Phonological Proximity in Costa Rican Sign Language

The study of phonological proximity makes it possible to establish a basis for future decision-making in the treatment of sign languages. Knowing how close a set of signs are allows the interested party to decide more easily its study by clustering, as well as the teaching of the language to third parties based on similarities. In addition, it lays the foundation for strengthening disambiguation modules in automatic recognition systems. To the best of our knowledge, this is the first study of its kind for Costa Rican Sign Language (LESCO, for its Spanish acronym), and forms the basis for one of the modules of the already operational system of sign and speech editing called the International Platform for Sign Language Edition (PIELS). A database of 2665 signs, grouped into eight contexts, is used, and a comparison of similarity measures is made, using standard statistical formulas to measure their degree of correlation. This corpus will be especially useful in machine learning approaches. In this work, we have proposed an analysis of different similarity measures between signs in order to find out the phonological proximity between them. After analyzing the results obtained, we can conclude that LESCO is a sign language with high levels of phonological proximity, particularly in the orientation and location components, but they are noticeably lower in the form component. We have also concluded as an outstanding contribution of our research that automatic recognition systems can take as a basis for their first prototypes the contexts or sign domains that map to clusters with lower levels of similarity. As mentioned, the results obtained have multiple applications such as in the teaching area or the Natural Language Processing area for automatic recognition tasks.This work was supported in part by the Spanish Ministry of Science, Innovation and Universities through the Project ECLIPSE-UA under Grant RTI2018-094283-B-C32, the Project INTEGER under Grant RTI2018-094649-B-I00, and partly by the Conselleria de Educación, Investigación, Cultura y Deporte of the Community of Valencia, Spain, within the Project PROMETEO/2018/089

Neo-Marshallian Nodes, Global Networks and Firm Competitiveness: The Media Cluster of Central London

The recent emphasis by some business scholars on processes taking place within locally-embedded production systems seems to undervalue the dynamics of global competition and the role played by TNCs in mobilising tangible and intangible assets across localised clusters. Using the external linkages of firms as the theoretical framework, this paper examines the interplay between global and local influences on the competitiveness of the cluster of media firms in Central London. The main findings are that the locality indeed plays a vital role in influencing the capabilities of these firms, but it is by no means the only relevant geographic area. This localised cluster is bound tightly into world-wide webs of interdependence, with TNCs playing a major role in mediating between local and global linkages. The latter are vital for the ability of the firms studied to compete successfully in international markets.

Disease Gene Interaction Pathways: A Potential Framework for How Disease Genes Associate by Disease-Risk Modules

BACKGROUND: Disease genes that interact cooperatively play crucial roles in the process of complex diseases, yet how to analyze and represent their associations is still an open problem. Traditional methods have failed to represent direct biological evidences that disease genes associate with each other in the pathogenesis of complex diseases. Molecular networks, assumed as 'a form of biological systems', consist of a set of interacting biological modules (functional modules or pathways) and this notion could provide a promising insight into deciphering this topic. METHODOLOGY/PRINCIPAL FINDINGS: In this paper, we hypothesized that disease genes might associate by virtue of the associations between biological modules in molecular networks. Then we introduced a novel disease gene interaction pathway representation and analysis paradigm, and managed to identify the disease gene interaction pathway for 61 known disease genes of coronary artery disease (CAD), which contained 46 disease-risk modules and 182 interaction relationships. As demonstrated, disease genes associate through prescribed communication protocols of common biological functions and pathways. CONCLUSIONS/SIGNIFICANCE: Our analysis was proved to be coincident with our primary hypothesis that disease genes of complex diseases interact with their neighbors in a cooperative manner, associate with each other through shared biological functions and pathways of disease-risk modules, and finally cause dysfunctions of a series of biological processes in molecular networks. We hope our paradigm could be a promising method to identify disease gene interaction pathways for other types of complex diseases, affording additional clues in the pathogenesis of complex diseases

Foreign and Indigenous Firms in the Media Cluster of Central London

This study uses the comparison between foreign and indigenous firms in localised clusters to gain insights into the behaviour of the former in clusters. In-depth study of 49 foreign and indigenous media firms in the soho district of central london suggests a combination of differences and similarities between them in terms of their cluster behaviour and the benefits they draw from their cluster participation. The major factor determining these differences and similarities is the extent to which internal linkages within tncs substitute for cluster linkages.tncs, clusters, media industries

The Global Challenges of the Knowledge Economy: China and the EU

This paper addresses some of the challenges confronting the European Union and China as they build their knowledge economies, and their on-going and possible future actions to address such challenges. Fifty years after the creation of what became the European Union, we argue that there is an urgent need to develop a new European Lisbon Agenda, preparing the EU for globalization. A new and "outward-looking" Lisbon strategy would focus on three key areas: international trade in services, internationalization of research networking, and access to brains and talent. The paper shows that the success of the Chinese economy over the past three decades can be partially attributed to its ability to absorb globally advanced technology and huge flows of foreign investment, its large pool of knowledge and talent, and its enactment of a policy framework that provides incentives to domestic and foreign firms to innovate - a strategy very much reminiscent of Europe's own internal Lisbon agenda. To move further, China needs to overcome the obstacles of regional disparities, transform its industry and deepen industry-academy linkages, which are also unavoidable tasks for the sustainable development of Europe. We contend that the scope for comparative studies of the EU and China, for mutual learning from each other's experience - even for joint initiatives - is substantial.Knowledge Economy, Industry-University Partnerships, Globalization, Internationalization, Highly Skilled Migration, European Union, China