Scalable multimodal convolutional networks for brain tumour segmentation

Brain tumour segmentation plays a key role in computer-assisted surgery. Deep neural networks have increased the accuracy of automatic segmentation significantly, however these models tend to generalise poorly to different imaging modalities than those for which they have been designed, thereby limiting their applications. For example, a network architecture initially designed for brain parcellation of monomodal T1 MRI can not be easily translated into an efficient tumour segmentation network that jointly utilises T1, T1c, Flair and T2 MRI. To tackle this, we propose a novel scalable multimodal deep learning architecture using new nested structures that explicitly leverage deep features within or across modalities. This aims at making the early layers of the architecture structured and sparse so that the final architecture becomes scalable to the number of modalities. We evaluate the scalable architecture for brain tumour segmentation and give evidence of its regularisation effect compared to the conventional concatenation approach.Comment: Paper accepted at MICCAI 201

Binding and Normalization of Binary Sparse Distributed Representations by Context-Dependent Thinning

Distributed representations were often criticized as inappropriate for encoding of data with a complex structure. However Plate's Holographic Reduced Representations and Kanerva's Binary Spatter Codes are recent schemes that allow on-the-fly encoding of nested compositional structures by real-valued or dense binary vectors of fixed dimensionality. In this paper we consider procedures of the Context-Dependent Thinning which were developed for representation of complex hierarchical items in the architecture of Associative-Projective Neural Networks. These procedures provide binding of items represented by sparse binary codevectors (with low probability of 1s). Such an encoding is biologically plausible and allows a high storage capacity of distributed associative memory where the codevectors may be stored. In contrast to known binding procedures, Context-Dependent Thinning preserves the same low density (or sparseness) of the bound codevector for varied number of component codevectors. Besides, a bound codevector is not only similar to another one with similar component codevectors (as in other schemes), but it is also similar to the component codevectors themselves. This allows the similarity of structures to be estimated just by the overlap of their codevectors, without retrieval of the component codevectors. This also allows an easy retrieval of the component codevectors. Examples of algorithmic and neural-network implementations of the thinning procedures are considered. We also present representation examples for various types of nested structured data (propositions using role-filler and predicate-arguments representation schemes, trees, directed acyclic graphs) using sparse codevectors of fixed dimension. Such representations may provide a fruitful alternative to the symbolic representations of traditional AI, as well as to the localist and microfeature-based connectionist representations

Dirichlet belief networks for topic structure learning

Recently, considerable research effort has been devoted to developing deep architectures for topic models to learn topic structures. Although several deep models have been proposed to learn better topic proportions of documents, how to leverage the benefits of deep structures for learning word distributions of topics has not yet been rigorously studied. Here we propose a new multi-layer generative process on word distributions of topics, where each layer consists of a set of topics and each topic is drawn from a mixture of the topics of the layer above. As the topics in all layers can be directly interpreted by words, the proposed model is able to discover interpretable topic hierarchies. As a self-contained module, our model can be flexibly adapted to different kinds of topic models to improve their modelling accuracy and interpretability. Extensive experiments on text corpora demonstrate the advantages of the proposed model.Comment: accepted in NIPS 201