The effect of the GLP-1 analogue Exenatide on functional connectivity within an NTS-based network in women with and without obesity.

ObjectiveThe differential effect of GLP-1 agonist Exenatide on functional connectivity of the nucleus tractus solitaries (NTS), a key region associated with homeostasis, and on appetite-related behaviours was investigated in women with normal weight compared with women with obesity.MethodsFollowing an 8-h fast, 19 female subjects (11 lean, 8 obese) participated in a 2-d double blind crossover study. Subjects underwent functional magnetic resonance imaging at fast and 30-min post subcutaneous injection of 5 μg of Exenatide or placebo. Functional connectivity was examined with the NTS. Drug-induced functional connectivity changes within and between groups and correlations with appetite measures were examined in a region of interest approach focusing on the thalamus and hypothalamus.ResultsWomen with obesity reported less hunger after drug injection. Exenatide administration increased functional connectivity of the left NTS with the left thalamus and hypothalamus in the obese group only and increased the correlation between NTS functional connectivity and hunger scores in all subjects, but more so in the obese.ConclusionsObesity can impact the effects of Exenatide on brain connectivity, specifically in the NTS and is linked to changes in appetite control. This has implications for the use of GLP-1 analogues in therapeutic interventions

Can we be both resilient and well, and what choices do people have? Incorporating agency into the resilience debate from a fisheries perspective.

In the midst of a global fisheries crisis, there has been great interest in the fostering of adaptation and resilience in fisheries, as a means to reduce vulnerability and improve the capacity of fishing society to adapt to change. However, enhanced resilience does not automatically result in improved well-being of people, and adaptation strategies are riddled with difficult choices, or trade-offs, that people must negotiate. This paper uses the context of fisheries to explore some apparent tensions between adapting to change on the one hand, and the pursuit of well-being on the other, and illustrates that trade-offs can operate at different levels of scale. It argues that policies that seek to support fisheries resilience need to be built on a better understanding of the wide range of consequences that adaptation has on fisher well-being, the agency people exert in negotiating their adaptation strategies, and how this feeds back into the resilience of fisheries as a social-ecological system. The paper draws from theories on agency and adaptive preferences to illustrate how agency might be better incorporated into the resilience debate

Lean and green – a systematic review of the state of the art literature

The move towards greener operations and products has forced companies to seek alternatives to balance efficiency gains and environmental friendliness in their operations and products. The exploration of the sequential or simultaneous deployment of lean and green initiatives is the results of this balancing action. However, the lean-green topic is relatively new, and it lacks of a clear and structured research definition. Thus, this paper’s main contribution is the offering of a systematic review of the existing literature on lean and green, aimed at providing guidance on the topic, uncovering gaps and inconsistencies in the literature, and finding new paths for research. The paper identifies and structures, through a concept map, six main research streams that comprise both conceptual and empirical research conducted within the context of various organisational functions and industrial sectors. Important issues for future research are then suggested in the form of research questions. The paper’s aim is to also contribute by stimulating scholars to further study this area in depth, which will lead to a better understanding of the compatibility and impact on organisational performance of lean and green initiatives. It also holds important implications for industrialists, who can develop a deeper and richer knowledge on lean and green to help them formulate more effective strategies for their deployment

Disentangling scale approaches in governance research: comparing monocentric, multilevel, and adaptive governance

The question of how to govern the multiscale problems in today’s network society is an important topic in the fields of public administration, political sciences, and environmental sciences. How scales are defined, studied, and dealt with varies substantially within and across these fields. This paper aims to reduce the existing conceptual confusion regarding scales by disentangling three representative approaches that address both governance and scaling: monocentric governance, multilevel governance, and adaptive governance. It does so by analyzing the differences in (1) underlying views on governing, (2) assumptions about scales, (3) dominant problem definitions regarding scales, and (4) preferred responses for dealing with multiple scales. Finally, this paper identifies research opportunities within and across these approaches

Sustainable and resilient supply chain management : scale development

Paper delivered at the 21st Logistics Research Network annual conference 2016, 7th-9th September 2016, Hull. Abstract Purpose: This paper reports on the status of an ongoing empirical study to enhance our understanding of factors contributing to better supply chain performance in the context of sustainable and resilient supply chain management, and updates the literature review and research framework presented in Joradon et al. (2015). That paper operationalized eight firm practices that are now being tested in a quantitative study to investigate how sustainable and resilient supply chain management might improve supply chain performance. Sustainable and resilient supply chain management requires firms to consider supply chain performance within environmental, economic, social, vulnerability, and capability parameters. This paper presents the scale development for this study which will analyse the current level of sustainable and resilient supply chain management practices in firms and help guide them to assess and amend their procedures and processes to become more sustainable and resilient in future. Research approach: The empirical study contains measurement scale and constructs developed according to Churchill (1979) two-phase framework. The first phase was based on data gathered from interviews with nine managers across four electronic companies and two distributors in Thailand using semi-structured interviews. The data from the interviews as well as the extant literature was then used to develop measurement scales and constructs for the next phase, which was a survey with approximately 500 electronic companies in Thailand. Findings and Originality: At the date of writing semi-structured interviews have been conducted and some opportunities to shape the measurement scale and constructs have been identified. The survey is currently being completed and the conference presentation will provide results from analysis to date. While the investigation of sustainable and resilient supply chain management together has yet to be explored in a focused way, this paper is original since it offers an investigation of these two topics and their relationship with supply chain performance. Research Impact: The study will produce new performance measurement scales for sustainable and resilient supply chain management as well as an agenda for future research to validate the findings across other sectors and contexts. Mixed-methodologies were applied in this study to ensure face, content and construct validity. Practical Impact: The study will provide direction for firms to measure their supply chain performance in the context of sustainable and resilient supply chain management practices, as well as a proposed set of measurement scales based on sustainable supply chain management and supply chain resilience management practices to measure the impact of these practices to the firm. The findings will help firms to understand their level of sustainable and resilient supply chain management in order to improve and adjust their procedures to be more sustainable and resilient in future

Applications of lean thinking: a briefing document

This report has been put together by the Health and Care Infrastructure Research and Innovation Centre (HaCIRIC) at the University of Salford for the Department of Health. The need for the report grew out of two main simple questions, o Is Lean applicable in sectors other than manufacturing? o Can the service delivery sector learn from the success of lean in manufacturing and realise the benefits of its implementation?The aim of the report is to list together examples of lean thinking as it is evidenced in the public and private service sector. Following a review of various sources a catalogue of evidence is put together in an organised manner which demonstrates that Lean principles and techniques, when applied rigorously and throughout an entire organization/unit, they can have a positive impact on productivity, cost, quality, and timely delivery of services