Algorithm Portfolios for Noisy Optimization

Noisy optimization is the optimization of objective functions corrupted by noise. A portfolio of solvers is a set of solvers equipped with an algorithm selection tool for distributing the computational power among them. Portfolios are widely and successfully used in combinatorial optimization. In this work, we study portfolios of noisy optimization solvers. We obtain mathematically proved performance (in the sense that the portfolio performs nearly as well as the best of its solvers) by an ad hoc portfolio algorithm dedicated to noisy optimization. A somehow surprising result is that it is better to compare solvers with some lag, i.e., propose the current recommendation of best solver based on their performance earlier in the run. An additional finding is a principled method for distributing the computational power among solvers in the portfolio.Comment: in Annals of Mathematics and Artificial Intelligence, Springer Verlag, 201

An Entropy Search Portfolio for Bayesian Optimization

Bayesian optimization is a sample-efficient method for black-box global optimization. How- ever, the performance of a Bayesian optimization method very much depends on its exploration strategy, i.e. the choice of acquisition function, and it is not clear a priori which choice will result in superior performance. While portfolio methods provide an effective, principled way of combining a collection of acquisition functions, they are often based on measures of past performance which can be misleading. To address this issue, we introduce the Entropy Search Portfolio (ESP): a novel approach to portfolio construction which is motivated by information theoretic considerations. We show that ESP outperforms existing portfolio methods on several real and synthetic problems, including geostatistical datasets and simulated control tasks. We not only show that ESP is able to offer performance as good as the best, but unknown, acquisition function, but surprisingly it often gives better performance. Finally, over a wide range of conditions we find that ESP is robust to the inclusion of poor acquisition functions.Comment: 10 pages, 5 figure

A recommender system for process discovery

Over the last decade, several algorithms for process discovery and process conformance have been proposed. Still, it is well-accepted that there is no dominant algorithm in any of these two disciplines, and then it is often difficult to apply them successfully. Most of these algorithms need a close-to expert knowledge in order to be applied satisfactorily. In this paper, we present a recommender system that uses portfolio-based algorithm selection strategies to face the following problems: to find the best discovery algorithm for the data at hand, and to allow bridging the gap between general users and process mining algorithms. Experiments performed with the developed tool witness the usefulness of the approach for a variety of instances.Peer ReviewedPostprint (author’s final draft

Tackling resistance: Emerging antimalarials and new parasite targets in the era of elimination [version 1; referees: 2 approved]

Malaria remains a significant contributor to global human mortality, and roughly half the world’s population is at risk for infection with Plasmodium spp. parasites. Aggressive control measures have reduced the global prevalence of malaria significantly over the past decade. However, resistance to available antimalarials continues to spread, including resistance to the widely used artemisinin-based combination therapies. Novel antimalarial compounds and therapeutic targets are greatly needed. This review will briefly discuss several promising current antimalarial development projects, including artefenomel, ferroquine, cipargamin, SJ733, KAF156, MMV048, and tafenoquine. In addition, we describe recent large-scale genetic and resistance screens that have been instrumental in target discovery. Finally, we highlight new antimalarial targets, which include essential transporters and proteases. These emerging antimalarial compounds and therapeutic targets have the potential to overcome multi-drug resistance in ongoing efforts toward malaria elimination