バイオハイブリッドロボティクス創成に向けた3次元細胞アセンブリと筋組織形成

研究種目：若手研究(A)研究期間：2014～2017課題番号：26709013研究代表者：秋山　佳丈研究者番号：80585878Other2014～2017年度科学研究費助成事業（若手研究(A)）研究成果報告書　課題番号：26709013　研究代表者：秋山　佳丈research repor

細胞の動的３次元パターニングによるオンチップ臓器へ挑戦

研究種目：挑戦的萌芽研究研究期間：2015～2017課題番号：15K14232研究代表者：秋山　佳丈研究者番号：80585878Other2015～2017年度科学研究費助成事業（挑戦的萌芽研究）研究成果報告書　課題番号：15K14232　研究代表者：秋山　佳丈research repor

Exploring communication and collective behaviour between spatially organised inorganic protocell communities

A living system profoundly relies on mass, information and energy interactions through cell-cell and cell-environment networks. As a step towards understanding such interactions, it is beneficial to design and create bottom-up artificial living systems from non-living components, with a specific focus on synergistic interactivity between artificial cells (protocells) and their local environment. Although there are several routes for fabricating protocellular systems, we recognise key challenges associated with a) developing protocellular models with high levels of organisational tunability, b) achieving cell-environment bilateral communication, and c) realising autonomous self-assembly and regulation of protocell systems. The aim of this thesis is thus to review some matrix-based and matrix-free methods of inorganic protocell (colloidosome) 3D-spatial organisation, as judicious system designs capable of cell-cell and cell-environment communication, collective behaviours, and dynamic self-assembly, in close relation with local environments.The first experimental chapter details assembly of colloidosomes within hydrogel or coacervate-based matrices. A droplet microfluidic technique is employed as a novel method for encapsulating segregated colloidosome colonies within alginate hydrogel microspheres. The technique exploits high tunability for customisable size, ratio, microscale geometry, and 3D-patterning parameters. Benefiting from the versatility associated with such matrix-based systems, the second experimental chapter develops 3D-organised colloidosomes for collective signalling and emergent behaviours. Notably, spatially segregated colonies show proximity-mediated chemical communication with increased kinetics compared to analogous homogenous arrangements. This proximity-enhanced colloidosome signalling is exploited, alongside segregated ionic/covalent crosslinking transitions in the environment, to obtain simultaneous structural degradation and resilience of hydrogel hemispheres as a programmable mechanism for protocell ejection. Colloidosomes are also employed as simple signalling hotspots within coacervate-matrix systems. The final experimental chapter aims to re-imagine colloidosome organisation into a matrix-free system, capable of dynamic self-assembly and self-sorting via electrostatically-active membrane appendages. Alginate-coated and chitosan-coated colloidosomes are either co-assembled or self-sorted, in response to varied pH environments. Again, these systems are highly coordinated with their environment and as such, can be spatially pattered according to temporal pH changes through endogenous enzyme catalysis. Furthermore, a spatiotemporal effect on the rate of colloidosome communication in the presence of a hostile guest molecule is demonstrated. <br/

An immersed boundary method for particles and bubbles in magnetohydrodynamic flows

This thesis presents a numerical method for the phase-resolving simulation of rigid particles and deformable bubbles in viscous, magnetohydrodynamic flows. The presented approach features solid robustness and high numerical efficiency. The implementation is three-dimensional and fully parallel suiting the needs of modern high-performance computing. In addition to the steps towards magnetohydrodynamics, the thesis covers method development with respect to the immersed boundary method which can be summarized in simple words by From rigid spherical particles to deformable bubbles. The development comprises the extension of an existing immersed boundary method to non-spherical particles and very low particle-to-fluid density ratios. A detailed study is dedicated to the complex interaction of particle shape, wake and particle dynamics. Furthermore, the representation of deformable bubble shapes, i.e. the coupling of the bubble shape to the fluid loads, is accounted for. The topic of bubble interaction is surveyed including bubble collision and coalescence and a new coalescence model is introduced. The thesis contains applications of the method to simulations of the rise of a single bubble and a bubble chain in liquid metal with and without magnetic field highlighting the major effects of the field on the bubble dynamics and the flow field. The effect of bubble coalescence is quantified for two closely adjacent bubble chains. A framework for large-scale simulations with many bubbles is provided to study complex multiphase phenomena like bubble-turbulence interaction in an efficient manner

Abstracts on Radio Direction Finding (1899 - 1995)

The files on this record represent the various databases that originally composed the CD-ROM issue of "Abstracts on Radio Direction Finding" database, which is now part of the Dudley Knox Library's Abstracts and Selected Full Text Documents on Radio Direction Finding (1899 - 1995) Collection. (See Calhoun record https://calhoun.nps.edu/handle/10945/57364 for further information on this collection and the bibliography). Due to issues of technological obsolescence preventing current and future audiences from accessing the bibliography, DKL exported and converted into the three files on this record the various databases contained in the CD-ROM. The contents of these files are: 1) RDFA_CompleteBibliography_xls.zip [RDFA_CompleteBibliography.xls: Metadata for the complete bibliography, in Excel 97-2003 Workbook format; RDFA_Glossary.xls: Glossary of terms, in Excel 97-2003 Workbookformat; RDFA_Biographies.xls: Biographies of leading figures, in Excel 97-2003 Workbook format]; 2) RDFA_CompleteBibliography_csv.zip [RDFA_CompleteBibliography.TXT: Metadata for the complete bibliography, in CSV format; RDFA_Glossary.TXT: Glossary of terms, in CSV format; RDFA_Biographies.TXT: Biographies of leading figures, in CSV format]; 3) RDFA_CompleteBibliography.pdf: A human readable display of the bibliographic data, as a means of double-checking any possible deviations due to conversion

Optics in Our Time

Optics, Lasers, Photonics, Optical Devices; Quantum Optics; Popular Science in Physics; History and Philosophical Foundations of Physic

Прикладна фізика : українсько-російсько-англійський тлумачний словник. У 4 т. Т. 1. А – Ж

Словник охоплює близько 30 тис. термінів з прикладної фізики і дотичних до неї галузей знань та їх тлумачення трьома мовами (українською, російською та англійською). Багато термінів і визначень, наведених у словнику, якими послуговуються у відповідній галузі знань, досі не входили до жодного зі спеціалізованих словників. Словник призначений для викладачів, науковців, інженерів, аспірантів, студентів вищих навчальних закладів, перекладачів з природничих і технічних дисциплін

Ahlfors circle maps and total reality: from Riemann to Rohlin

This is a prejudiced survey on the Ahlfors (extremal) function and the weaker {\it circle maps} (Garabedian-Schiffer's translation of "Kreisabbildung"), i.e. those (branched) maps effecting the conformal representation upon the disc of a {\it compact bordered Riemann surface}. The theory in question has some well-known intersection with real algebraic geometry, especially Klein's ortho-symmetric curves via the paradigm of {\it total reality}. This leads to a gallery of pictures quite pleasant to visit of which we have attempted to trace the simplest representatives. This drifted us toward some electrodynamic motions along real circuits of dividing curves perhaps reminiscent of Kepler's planetary motions along ellipses. The ultimate origin of circle maps is of course to be traced back to Riemann's Thesis 1851 as well as his 1857 Nachlass. Apart from an abrupt claim by Teichm\"uller 1941 that everything is to be found in Klein (what we failed to assess on printed evidence), the pivotal contribution belongs to Ahlfors 1950 supplying an existence-proof of circle maps, as well as an analysis of an allied function-theoretic extremal problem. Works by Yamada 1978--2001, Gouma 1998 and Coppens 2011 suggest sharper degree controls than available in Ahlfors' era. Accordingly, our partisan belief is that much remains to be clarified regarding the foundation and optimal control of Ahlfors circle maps. The game of sharp estimation may look narrow-minded "Absch\"atzungsmathematik" alike, yet the philosophical outcome is as usual to contemplate how conformal and algebraic geometry are fighting together for the soul of Riemann surfaces. A second part explores the connection with Hilbert's 16th as envisioned by Rohlin 1978.Comment: 675 pages, 199 figures; extended version of the former text (v.1) by including now Rohlin's theory (v.2