Disease diagnosis in smart healthcare: Innovation, technologies and applications

To promote sustainable development, the smart city implies a global vision that merges artificial intelligence, big data, decision making, information and communication technology (ICT), and the internet-of-things (IoT). The ageing issue is an aspect that researchers, companies and government should devote efforts in developing smart healthcare innovative technology and applications. In this paper, the topic of disease diagnosis in smart healthcare is reviewed. Typical emerging optimization algorithms and machine learning algorithms are summarized. Evolutionary optimization, stochastic optimization and combinatorial optimization are covered. Owning to the fact that there are plenty of applications in healthcare, four applications in the field of diseases diagnosis (which also list in the top 10 causes of global death in 2015), namely cardiovascular diseases, diabetes mellitus, Alzheimer’s disease and other forms of dementia, and tuberculosis, are considered. In addition, challenges in the deployment of disease diagnosis in healthcare have been discussed

A Unified Framework for Gradient-based Hyperparameter Optimization and Meta-learning

Machine learning algorithms and systems are progressively becoming part of our societies, leading to a growing need of building a vast multitude of accurate, reliable and interpretable models which should possibly exploit similarities among tasks. Automating segments of machine learning itself seems to be a natural step to undertake to deliver increasingly capable systems able to perform well in both the big-data and the few-shot learning regimes. Hyperparameter optimization (HPO) and meta-learning (MTL) constitute two building blocks of this growing effort. We explore these two topics under a unifying perspective, presenting a mathematical framework linked to bilevel programming that captures existing similarities and translates into procedures of practical interest rooted in algorithmic differentiation. We discuss the derivation, applicability and computational complexity of these methods and establish several approximation properties for a class of objective functions of the underlying bilevel programs. In HPO, these algorithms generalize and extend previous work on gradient-based methods. In MTL, the resulting framework subsumes classic and emerging strategies and provides a starting basis from which to build and analyze novel techniques. A series of examples and numerical simulations offer insight and highlight some limitations of these approaches. Experiments on larger-scale problems show the potential gains of the proposed methods in real-world applications. Finally, we develop two extensions of the basic algorithms apt to optimize a class of discrete hyperparameters (graph edges) in an application to relational learning and to tune online learning rate schedules for training neural network models, an old but crucially important issue in machine learning

Machine Learning Methods for Structural Brain MRIs: Applications for Alzheimer’s Disease and Autism Spectrum Disorder

This thesis deals with the development of novel machine learning applications to automatically detect brain disorders based on magnetic resonance imaging (MRI) data, with a particular focus on Alzheimer’s disease and the autism spectrum disorder. Machine learning approaches are used extensively in neuroimaging studies of brain disorders to investigate abnormalities in various brain regions. However, there are many technical challenges in the analysis of neuroimaging data, for example, high dimensionality, the limited amount of data, and high variance in that data due to many confounding factors. These limitations make the development of appropriate computational approaches more challenging. To deal with these existing challenges, we target multiple machine learning approaches, including supervised and semi-supervised learning, domain adaptation, and dimensionality reduction methods.In the current study, we aim to construct effective biomarkers with sufficient sensitivity and specificity that can help physicians better understand the diseases and make improved diagnoses or treatment choices. The main contributions are 1) development of a novel biomarker for predicting Alzheimer’s disease in mild cognitive impairment patients by integrating structural MRI data and neuropsychological test results and 2) the development of a new computational approach for predicting disease severity in autistic patients in agglomerative data by automatically combining structural information obtained from different brain regions.In addition, we investigate various data-driven feature selection and classification methods for whole brain, voxel-based classification analysis of structural MRI and the use of semi-supervised learning approaches to predict Alzheimer’s disease. We also analyze the relationship between disease-related structural changes and cognitive states of patients with Alzheimer’s disease.The positive results of this effort provide insights into how to construct better biomarkers based on multisource data analysis of patient and healthy cohorts that may enable early diagnosis of brain disorders, detection of brain abnormalities and understanding effective processing in patient and healthy groups. Further, the methodologies and basic principles presented in this thesis are not only suited to the studied cases, but also are applicable to other similar problems

Deep Learning Methods for Remote Sensing

Remote sensing is a field where important physical characteristics of an area are exacted using emitted radiation generally captured by satellite cameras, sensors onboard aerial vehicles, etc. Captured data help researchers develop solutions to sense and detect various characteristics such as forest fires, flooding, changes in urban areas, crop diseases, soil moisture, etc. The recent impressive progress in artificial intelligence (AI) and deep learning has sparked innovations in technologies, algorithms, and approaches and led to results that were unachievable until recently in multiple areas, among them remote sensing. This book consists of sixteen peer-reviewed papers covering new advances in the use of AI for remote sensing

Classification techniques on computerized systems to predict and/or to detect Apnea: A systematic review

Sleep apnea syndrome (SAS), which can significantly decrease the quality of life is associated with a major risk factor of health implications such as increased cardiovascular disease, sudden death, depression, irritability, hypertension, and learning difficulties. Thus, it is relevant and timely to present a systematic review describing significant applications in the framework of computational intelligence-based SAS, including its performance, beneficial and challenging effects, and modeling for the decision-making on multiple scenarios.info:eu-repo/semantics/publishedVersio

Antenna Systems

This book offers an up-to-date and comprehensive review of modern antenna systems and their applications in the fields of contemporary wireless systems. It constitutes a useful resource of new material, including stochastic versus ray tracing wireless channel modeling for 5G and V2X applications and implantable devices. Chapters discuss modern metalens antennas in microwaves, terahertz, and optical domain. Moreover, the book presents new material on antenna arrays for 5G massive MIMO beamforming. Finally, it discusses new methods, devices, and technologies to enhance the performance of antenna systems

Fast IDentity Online with Anonymous Credentials (FIDO-AC)

Web authentication is a critical component of today's Internet and the digital world we interact with. The FIDO2 protocol enables users to leverage common devices to easily authenticate to online services in both mobile and desktop environments following the passwordless authentication approach based on cryptography and biometric verification. However, there is little to no connection between the authentication process and users' attributes. More specifically, the FIDO protocol does not specify methods that could be used to combine trusted attributes with the FIDO authentication process generically and allows users to disclose them to the relying party arbitrarily. In essence, applications requiring attributes verification (e.g. age or expiry date of a driver's license, etc.) still rely on ad-hoc approaches, not satisfying the data minimization principle and not allowing the user to vet the disclosed data. A primary recent example is the data breach on Singtel Optus, one of the major telecommunications providers in Australia, where very personal and sensitive data (e.g. passport numbers) were leaked. This paper introduces FIDO-AC, a novel framework that combines the FIDO2 authentication process with the user's digital and non-shareable identity. We show how to instantiate this framework using off-the-shelf FIDO tokens and any electronic identity document, e.g., the ICAO biometric passport (ePassport). We demonstrate the practicality of our approach by evaluating a prototype implementation of the FIDO-AC system.Comment: to be published in the 32nd USENIX Security Symposium(USENIX 2023

Explainable Neural Networks based Anomaly Detection for Cyber-Physical Systems

Cyber-Physical Systems (CPSs) are the core of modern critical infrastructure (e.g. power-grids) and securing them is of paramount importance. Anomaly detection in data is crucial for CPS security. While Artificial Neural Networks (ANNs) are strong candidates for the task, they are seldom deployed in safety-critical domains due to the perception that ANNs are black-boxes. Therefore, to leverage ANNs in CPSs, cracking open the black box through explanation is essential. The main objective of this dissertation is developing explainable ANN-based Anomaly Detection Systems for Cyber-Physical Systems (CP-ADS). The main objective was broken down into three sub-objectives: 1) Identifying key-requirements that an explainable CP-ADS should satisfy, 2) Developing supervised ANN-based explainable CP-ADSs, 3) Developing unsupervised ANN-based explainable CP-ADSs. In achieving those objectives, this dissertation provides the following contributions: 1) a set of key-requirements that an explainable CP-ADS should satisfy, 2) a methodology for deriving summaries of the knowledge of a trained supervised CP-ADS, 3) a methodology for validating derived summaries, 4) an unsupervised neural network methodology for learning cyber-physical (CP) behavior, 5) a methodology for visually and linguistically explaining the learned CP behavior. All the methods were implemented on real-world and benchmark datasets. The set of key-requirements presented in the first contribution was used to evaluate the performance of the presented methods. The successes and limitations of the presented methods were identified. Furthermore, steps that can be taken to overcome the limitations were proposed. Therefore, this dissertation takes several necessary steps toward developing explainable ANN-based CP-ADS and serves as a framework that can be expanded to develop trustworthy ANN-based CP-ADSs

Biomedical Photoacoustic Imaging and Sensing Using Affordable Resources

The overarching goal of this book is to provide a current picture of the latest developments in the capabilities of biomedical photoacoustic imaging and sensing in an affordable setting, such as advances in the technology involving light sources, and delivery, acoustic detection, and image reconstruction and processing algorithms. This book includes 14 chapters from globally prominent researchers , covering a comprehensive spectrum of photoacoustic imaging topics from technology developments and novel imaging methods to preclinical and clinical studies, predominantly in a cost-effective setting. Affordability is undoubtedly an important factor to be considered in the following years to help translate photoacoustic imaging to clinics around the globe. This first-ever book focused on biomedical photoacoustic imaging and sensing using affordable resources is thus timely, especially considering the fact that this technique is facing an exciting transition from benchtop to bedside. Given its scope, the book will appeal to scientists and engineers in academia and industry, as well as medical experts interested in the clinical applications of photoacoustic imaging