Revealing ensemble state transition patterns in multi-electrode neuronal recordings using hidden Markov models

In order to harness the computational capacity of dissociated cultured neuronal networks, it is necessary to understand neuronal dynamics and connectivity on a mesoscopic scale. To this end, this paper uncovers dynamic spatiotemporal patterns emerging from electrically stimulated neuronal cultures using hidden Markov models (HMMs) to characterize multi-channel spike trains as a progression of patterns of underlying states of neuronal activity. However, experimentation aimed at optimal choice of parameters for such models is essential and results are reported in detail. Results derived from ensemble neuronal data revealed highly repeatable patterns of state transitions in the order of milliseconds in response to probing stimuli

Geometric deep learning: going beyond Euclidean data

Many scientific fields study data with an underlying structure that is a non-Euclidean space. Some examples include social networks in computational social sciences, sensor networks in communications, functional networks in brain imaging, regulatory networks in genetics, and meshed surfaces in computer graphics. In many applications, such geometric data are large and complex (in the case of social networks, on the scale of billions), and are natural targets for machine learning techniques. In particular, we would like to use deep neural networks, which have recently proven to be powerful tools for a broad range of problems from computer vision, natural language processing, and audio analysis. However, these tools have been most successful on data with an underlying Euclidean or grid-like structure, and in cases where the invariances of these structures are built into networks used to model them. Geometric deep learning is an umbrella term for emerging techniques attempting to generalize (structured) deep neural models to non-Euclidean domains such as graphs and manifolds. The purpose of this paper is to overview different examples of geometric deep learning problems and present available solutions, key difficulties, applications, and future research directions in this nascent field

Multitask Learning Deep Neural Networks to Combine Revealed and Stated Preference Data

It is an enduring question how to combine revealed preference (RP) and stated preference (SP) data to analyze travel behavior. This study presents a framework of multitask learning deep neural networks (MTLDNNs) for this question, and demonstrates that MTLDNNs are more generic than the traditional nested logit (NL) method, due to its capacity of automatic feature learning and soft constraints. About 1,500 MTLDNN models are designed and applied to the survey data that was collected in Singapore and focused on the RP of four current travel modes and the SP with autonomous vehicles (AV) as the one new travel mode in addition to those in RP. We found that MTLDNNs consistently outperform six benchmark models and particularly the classical NL models by about 5% prediction accuracy in both RP and SP datasets. This performance improvement can be mainly attributed to the soft constraints specific to MTLDNNs, including its innovative architectural design and regularization methods, but not much to the generic capacity of automatic feature learning endowed by a standard feedforward DNN architecture. Besides prediction, MTLDNNs are also interpretable. The empirical results show that AV is mainly the substitute of driving and AV alternative-specific variables are more important than the socio-economic variables in determining AV adoption. Overall, this study introduces a new MTLDNN framework to combine RP and SP, and demonstrates its theoretical flexibility and empirical power for prediction and interpretation. Future studies can design new MTLDNN architectures to reflect the speciality of RP and SP and extend this work to other behavioral analysis

Numerical Implementation of Gradient Algorithms

A numerical method for computational implementation of gradient dynamical systems is presented. The method is based upon the development of geometric integration numerical methods, which aim at preserving the dynamical properties of the original ordinary differential equation under discretization. In particular, the proposed method belongs to the class of discrete gradients methods, which substitute the gradient of the continuous equation with a discrete gradient, leading to a map that possesses the same Lyapunov function of the dynamical system, thus preserving the qualitative properties regardless of the step size. In this work, we apply a discrete gradient method to the implementation of Hopfield neural networks. Contrary to most geometric integration methods, the proposed algorithm can be rewritten in explicit form, which considerably improves its performance and stability. Simulation results show that the preservation of the Lyapunov function leads to an improved performance, compared to the conventional discretization.Spanish Government project no. TIN2010-16556 Junta de Andalucía project no. P08-TIC-04026 Agencia Española de Cooperación Internacional para el Desarrollo project no. A2/038418/1

Application of Stationary Wavelet Support Vector Machines for the Prediction of Economic Recessions

This paper examines the efficiency of various approaches on the classification and prediction of economic expansion and recession periods in United Kingdom. Four approaches are applied. The first is discrete choice models using Logit and Probit regressions, while the second approach is a Markov Switching Regime (MSR) Model with Time-Varying Transition Probabilities. The third approach refers on Support Vector Machines (SVM), while the fourth approach proposed in this study is a Stationary Wavelet SVM modelling. The findings show that SW-SVM and MSR present the best forecasting performance, in the out-of sample period. In addition, the forecasts for period 2012-2015 are provided using all approaches