ECG study in practical labs for biomedical engineering training

Non-invasive biomedical measurements are one of the most important technological contributions whitin the biomedical engineering field. On this paper, a dual laboratory session student oriented is designed to simulate and implement a cardial signal monitor. During the first session, ORCAD PSpice software is used to simulate the whole process. The students can acquire knowledge on the process by configuring and running both the instrumentation amplifier and a passive filter to improve the signal quality. The second session requires from the student basic laboratory skills to use a specific printed circuit board (PCB) to measure its very own cardiac potential. As a result, from this session, the student can visualize the ECG signal acquired directly on the laboratory oscilloscope

Space Station Freedom ECLSS: A step toward autonomous regenerative life support systems

The Environmental Control and Life Support System (ECLSS) is a Freedom Station distributed system with inherent applicability to extensive automation primarily due to its comparatively long control system latencies. These allow longer contemplation times in which to form a more intelligent control strategy and to prevent and diagnose faults. The regenerative nature of the Space Station Freedom ECLSS will contribute closed loop complexities never before encountered in life support systems. A study to determine ECLSS automation approaches has been completed. The ECLSS baseline software and system processes could be augmented with more advanced fault management and regenerative control systems for a more autonomous evolutionary system, as well as serving as a firm foundation for future regenerative life support systems. Emerging advanced software technology and tools can be successfully applied to fault management, but a fully automated life support system will require research and development of regenerative control systems and models. The baseline Environmental Control and Life Support System utilizes ground tests in development of batch chemical and microbial control processes. Long duration regenerative life support systems will require more active chemical and microbial feedback control systems which, in turn, will require advancements in regenerative life support models and tools. These models can be verified using ground and on orbit life support test and operational data, and used in the engineering analysis of proposed intelligent instrumentation feedback and flexible process control technologies for future autonomous regenerative life support systems, including the evolutionary Space Station Freedom ECLSS

Laser Based Mid-Infrared Spectroscopic Imaging – Exploring a Novel Method for Application in Cancer Diagnosis

A number of biomedical studies have shown that mid-infrared spectroscopic images can provide both morphological and biochemical information that can be used for the diagnosis of cancer. Whilst this technique has shown great potential it has yet to be employed by the medical profession. By replacing the conventional broadband thermal source employed in modern FTIR spectrometers with high-brightness, broadly tuneable laser based sources (QCLs and OPGs) we aim to solve one of the main obstacles to the transfer of this technology to the medical arena; namely poor signal to noise ratios at high spatial resolutions and short image acquisition times. In this thesis we take the first steps towards developing the optimum experimental configuration, the data processing algorithms and the spectroscopic image contrast and enhancement methods needed to utilise these high intensity laser based sources. We show that a QCL system is better suited to providing numerical absorbance values (biochemical information) than an OPG system primarily due to the QCL pulse stability. We also discuss practical protocols for the application of spectroscopic imaging to cancer diagnosis and present our spectroscopic imaging results from our laser based spectroscopic imaging experiments of oesophageal cancer tissue

Fault diagnostic instrumentation design for environmental control and life support systems

As a development phase moves toward flight hardware, the system availability becomes an important design aspect which requires high reliability and maintainability. As part of continous development efforts, a program to evaluate, design, and demonstrate advanced instrumentation fault diagnostics was successfully completed. Fault tolerance designs for reliability and other instrumenation capabilities to increase maintainability were evaluated and studied

Implementing a real time reasoning system for robust diagnosis

The objective of the Thermal Control System Automation Project (TCSAP) is to develop an advanced fault detection, isolation, and recovery (FDIR) capability for use on the Space Station Freedom (SSF) External Active Thermal Control System (EATCS). Real-time monitoring, control, and diagnosis of the EATCS will be performed with a knowledge based system (KBS). Implementation issues for the current version of the KBS are discussed

Intelligent fault management for the Space Station active thermal control system

The Thermal Advanced Automation Project (TAAP) approach and architecture is described for automating the Space Station Freedom (SSF) Active Thermal Control System (ATCS). The baseline functionally and advanced automation techniques for Fault Detection, Isolation, and Recovery (FDIR) will be compared and contrasted. Advanced automation techniques such as rule-based systems and model-based reasoning should be utilized to efficiently control, monitor, and diagnose this extremely complex physical system. TAAP is developing advanced FDIR software for use on the SSF thermal control system. The goal of TAAP is to join Knowledge-Based System (KBS) technology, using a combination of rules and model-based reasoning, with conventional monitoring and control software in order to maximize autonomy of the ATCS. TAAP's predecessor was NASA's Thermal Expert System (TEXSYS) project which was the first large real-time expert system to use both extensive rules and model-based reasoning to control and perform FDIR on a large, complex physical system. TEXSYS showed that a method is needed for safely and inexpensively testing all possible faults of the ATCS, particularly those potentially damaging to the hardware, in order to develop a fully capable FDIR system. TAAP therefore includes the development of a high-fidelity simulation of the thermal control system. The simulation provides realistic, dynamic ATCS behavior and fault insertion capability for software testing without hardware related risks or expense. In addition, thermal engineers will gain greater confidence in the KBS FDIR software than was possible prior to this kind of simulation testing. The TAAP KBS will initially be a ground-based extension of the baseline ATCS monitoring and control software and could be migrated on-board as additional computation resources are made available

Heart Failure Anticoagulation Teach-Back Education and Readmissions

abstract: Heart failure affects millions of Americans each year. Treatment of advanced heart failure with reduced ejection fraction and left ventricular failure is sometimes treated with implantation of a left-ventricular assist device. While living with this life-sustaining machine, anticoagulation with Coumadin is necessary. Many of these patients are readmitted within 30-days of being discharged for pump clots, gastro-intestinal bleeds and even strokes. Patients are often discharged without adequate education on Coumadin management, which promotes inadequate self-care and medication non-adherence. In current practice, healthcare providers lecture information in a quick manner without the evaluation of patients’ comprehension. Research suggests implementing the teach-back method during education sessions to assess for comprehension of material to improve medication adherence. Healthcare providers should implement Coumadin teach-back education to heart failure patients with left-ventricular assist devices to improve quality of life, increase medication adherence and decrease 30-day hospital readmission rates

Uncertainty Analysis of Feature Extraction from Expired Gas Traces

Noninvasive medical analyses are a convenient method to study several pathologies even though their indirect nature often requires a complex processing to determine the relevant health "indicators". The usefulness of such indicators depends on the employed model, but also on the uncertainty that is connected to the complex processing involved in the indicator determination. This paper deals with the problems related to the estimation of the uncertainty when the indicators are computed by means of a nontrivial processing on recorded traces of clinical parameters. The paper is focused on the analysis of expired gas traces, but the procedure can also be applied to many other cases where the processing involves manual or automatic selection of suitable "key points" on repetitive traces

U-health expert system with statistical neural network

Ubiquitous Health(U-Health) system witch focuses on automated applications that can provide healthcare to human anywhere and anytime using wired and wireless mobile technologies is becoming increasingly important. This system consists of a network system to collect data and a sensor module which measures pulse, blood pressure, diabetes, blood sugar, body fat diet with management and measurement of stress etc, by both wired and wireless and further portable mobile connections. In this paper, we propose an expert system using back-propagation to support the diagnosis of citizens in U-Health system

The future of laboratory medicine - A 2014 perspective.

Predicting the future is a difficult task. Not surprisingly, there are many examples and assumptions that have proved to be wrong. This review surveys the many predictions, beginning in 1887, about the future of laboratory medicine and its sub-specialties such as clinical chemistry and molecular pathology. It provides a commentary on the accuracy of the predictions and offers opinions on emerging technologies, economic factors and social developments that may play a role in shaping the future of laboratory medicine