Community-Based Watershed Planning in the Kingston Lake Watershed of Northeastern South Carolina

2008 S.C. Water Resources Conference - Addressing Water Challenges Facing the State and Regio

The B&C Kinematograph Company and British Cinema

This book sheds new light on the under-researched period of early British cinema through an in-depth history of the British and Colonial Kinematograph Company – also known as ‘B&C’– in the years 1908-1916, the period when it became one of Britain’s leading film producers. It provides an account of its films and personalities, and explores its production methods, business practices and policy changes. Gerry Turvey examines the range of short film genres B&C manufactured, including newsworthy topicals and comics, and series dramas, and how they often drew on the resources of urban Britain’s existing popular culture – from cheap reading matter to East End melodramas. He discusses B&C’s first open-air studio in East Finchley, its extensive use of location filming, and its large, state-of-the-art studio at Walthamstow. He also investigates how the films were photographed and ‘staged’, their developing formal properties, and how the choice of genres shifted radically over time in an attempt to seek new audiences

The effect of regular exercise on insulin sensitivity in type 2 diabetes mellitus: A systematic review and meta-analysis

The purpose of this study was to examine the effect of regular exercise training on insulin sensitivity in adults with type 2 diabetes mellitus ( T2DM ) using the pooled data available from randomised controlled trials. In addition, we sought to determine whether short-term periods of physical inactivity diminish the exercise-induced improvement in insulin sensitivity. Eligible trials included exercise interventions that involved ≥3 exercise sessions, and reported a dynamic measurement of insulin sensitivity. There was a significant pooled effect size ( ES ) for the effect of exercise on insulin sensitivity ( ES, –0.588; 95% confidence interval [CI], –0.816 to –0.359; P < 0.001 ). Of the 14 studies included for meta-analyses, nine studies reported the time of data collection from the last exercise bout. There was a significant improvement in insulin sensitivity in favour of exercise versus control between 48 and 72 hours after exercise ( ES, –0.702; 95% CI, –1.392 to –0.012; P=0.046 ); and this persisted when insulin sensitivity was measured more than 72 hours after the last exercise session ( ES, –0.890; 95% CI, –1.675 to –0.105; P=0.026 ). Regular exercise has a significant benefit on insulin sensitivity in adults with T2DM and this may persist beyond 72 hours after the last exercise session

Assessment of biotransformation rates of organic compounds in mammals using in-vitro S9 bioassays

The overall objective of this study was to develop an in vitro based screening approach to determine the biotransformation rate constants of neutral hydrophobic organic chemicals in rats from rat liver S9 bioassays, and to test this screening approach by comparing in-vitro predicted biotransformation rates to in-vivo measured biotransformation rates. The test chemicals used for this study were pyrene, benzo(a)pyrene, hexachlorocyclohexane-beta, methoxychlor, mono-n-butyl phthalate, and 4-n-nonylphenol. In-vitro biotransformation rate constants were successfully obtained for all test chemicals and extrapolated to whole organism biotransformation rate constants using various IVIVE models. All the model outputs (IVIVE &amp; QSAR) were compared to one another using descriptive statistical analysis. Various statistical parameters imply that all IVIVE models are very similar in performance. This indicates that the IVIVE-b model and IVIVE-Krause &amp; Goss model (blood flow not considered), which require fewer biological parameters, could be used instead of the IVIVE-ph and IVIVE-Krause &amp; Goss model (blood flow considered) for bioaccumulation assessment. Additionally, the IVIVE models were shown to perform slightly better than the QSAR models, indicating that the IVIVE models might be a better tool for estimating biotransformation rate constants compare the QSAR models. However, due to the variability in the in-vivo data and only a few chemicals being tested, a definitive conclusion cannot be made regarding which model performs the best. Furthermore, the IVIVE and QSAR models could be further upgraded in the future and only time will tell which models are the best for predicting whole organism biotransformation rate constants in rats

Individualized decision aid for diverse women with lupus nephritis (IDEA-WON): A randomized controlled trial.

BackgroundTreatment decision-making regarding immunosuppressive therapy is challenging for individuals with lupus. We assessed the effectiveness of a decision aid for immunosuppressive therapy in lupus nephritis.Methods and findingsIn a United States multicenter, open-label, randomized controlled trial (RCT), adult women with lupus nephritis, mostly from racial/ethnic minority backgrounds with low socioeconomic status (SES), seen in in- or outpatient settings, were randomized to an individualized, culturally tailored, computerized decision aid versus American College of Rheumatology (ACR) lupus pamphlet (1:1 ratio), using computer-generated randomization. We hypothesized that the co-primary outcomes of decisional conflict and informed choice regarding immunosuppressive medications would improve more in the decision aid group. Of 301 randomized women, 298 were analyzed; 47% were African-American, 26% Hispanic, and 15% white. Mean age (standard deviation [SD]) was 37 (12) years, 57% had annual income of &lt;$40,000, and 36% had a high school education or less. Compared with the provision of the ACR lupus pamphlet (n = 147), participants randomized to the decision aid (n = 151) had (1) a clinically meaningful and statistically significant reduction in decisional conflict, 21.8 (standard error [SE], 2.5) versus 12.7 (SE, 2.0; p = 0.005) and (2) no difference in informed choice in the main analysis, 41% versus 31% (p = 0.08), but clinically meaningful and statistically significant difference in sensitivity analysis (net values for immunosuppressives positive [in favor] versus negative [against]), 50% versus 35% (p = 0.006). Unresolved decisional conflict was lower in the decision aid versus pamphlet groups, 22% versus 44% (p &lt; 0.001). Significantly more patients in the decision aid versus pamphlet group rated information to be excellent for understanding lupus nephritis (49% versus 33%), risk factors (43% versus 27%), medication options (50% versus 33%; p ≤ 0.003 for all); and the ease of use of materials was higher in the decision aid versus pamphlet groups (51% versus 38%; p = 0.006). Key study limitations were the exclusion of men, short follow-up, and the lack of clinical outcomes, including medication adherence.ConclusionsAn individualized decision aid was more effective than usual care in reducing decisional conflict for choice of immunosuppressive medications in women with lupus nephritis.Trial registrationClinicaltrials.gov, NCT02319525

The virtual reality of Russian prisons : the impact of social media on prisoner agency and prison structure in Russian prisons

Prison agencies around the world are reporting a rise in the use of illicit communication devices in prison. Nevertheless, there is very little prison sociological research into how prisoners themselves communicate online. Using Russia as a case study, this paper reports findings from new research on how prisoners are engaging with the internet and the effects of this on prisoner agency and prison structure. Our main finding is that Russian penality sits at the nexus of two processes. First, it is de-institutionalised in that the prison, discursively speaking, is no longer fixed to a built form. Second, it is reflexively re-territorialised in that it places prisoner agency onto a third space. The paper presents a new conceptual framework of ‘prisoners as absent’, which reflects penality in Russia as culturally contingent and politically resilient. The interplay between de-institutionalisation and re-territorialisation has produced on a new penal imaginary - a carceral motif for the twenty first century - in the form of a virtual world

Metabolic Complementarity and Genomics of the Dual Bacterial Symbiosis of Sharpshooters

Mutualistic intracellular symbiosis between bacteria and insects is a widespread phenomenon that has contributed to the global success of insects. The symbionts, by provisioning nutrients lacking from diets, allow various insects to occupy or dominate ecological niches that might otherwise be unavailable. One such insect is the glassy-winged sharpshooter (Homalodisca coagulata), which feeds on xylem fluid, a diet exceptionally poor in organic nutrients. Phylogenetic studies based on rRNA have shown two types of bacterial symbionts to be coevolving with sharpshooters: the gamma-proteobacterium Baumannia cicadellinicola and the Bacteroidetes species Sulcia muelleri. We report here the sequencing and analysis of the 686,192–base pair genome of B. cicadellinicola and approximately 150 kilobase pairs of the small genome of S. muelleri, both isolated from H. coagulata. Our study, which to our knowledge is the first genomic analysis of an obligate symbiosis involving multiple partners, suggests striking complementarity in the biosynthetic capabilities of the two symbionts: B. cicadellinicola devotes a substantial portion of its genome to the biosynthesis of vitamins and cofactors required by animals and lacks most amino acid biosynthetic pathways, whereas S. muelleri apparently produces most or all of the essential amino acids needed by its host. This finding, along with other results of our genome analysis, suggests the existence of metabolic codependency among the two unrelated endosymbionts and their insect host. This dual symbiosis provides a model case for studying correlated genome evolution and genome reduction involving multiple organisms in an intimate, obligate mutualistic relationship. In addition, our analysis provides insight for the first time into the differences in symbionts between insects (e.g., aphids) that feed on phloem versus those like H. coagulata that feed on xylem. Finally, the genomes of these two symbionts provide potential targets for controlling plant pathogens such as Xylella fastidiosa, a major agroeconomic problem, for which H. coagulata and other sharpshooters serve as vectors of transmission