Datamining for Web-Enabled Electronic Business Applications

Web-Enabled Electronic Business is generating massive amount of data on customer purchases, browsing patterns, usage times and preferences at an increasing rate. Data mining techniques can be applied to all the data being collected for obtaining useful information. This chapter attempts to present issues associated with data mining for web-enabled electronic-business

Integration via Meaning: Using the Semantic Web to deliver Web Services

Presented at the CRIS2002 Conference in Kassel.-- 9 pages.-- Contains: Conference paper (PDF) + PPT presentation.The major developments of the World Wide Web (WWW) in the last two years have been Web Services and the Semantic Web. The former allows the construction of distributed systems across the WWW by providing a lightweight middleware architecture. The latter provides an infrastructure for accessing resources on the WWW via their relationships with respect to conceptual descriptions. In this paper, I shall review the progress undertaken in each of these two areas. Further, I shall argue that in order for the aims of both the Semantic Web and the Web Services activities to be successful, then the Web Service architecture needs to be augmented by concepts and tools of the Semantic Web. This infrastructure will allow resource discovery, brokering and access to be enabled in a standardised, integrated and interoperable manner. Finally, I survey the CLRC Information Technology R&D programme to show how it is contributing to the development of this future infrastructure

FAIR principles and the IEDB: short-term improvements and a long-term vision of OBO-foundry mediated machine-actionable interoperability.

The Immune Epitope Database (IEDB), at www.iedb.org, has the mission to make published experimental data relating to the recognition of immune epitopes easily available to the scientific public. By presenting curated data in a searchable database, we have liberated it from the tables and figures of journal articles, making it more accessible and usable by immunologists. Recently, the principles of Findability, Accessibility, Interoperability and Reusability have been formulated as goals that data repositories should meet to enhance the usefulness of their data holdings. We here examine how the IEDB complies with these principles and identify broad areas of success, but also areas for improvement. We describe short-term improvements to the IEDB that are being implemented now, as well as a long-term vision of true 'machine-actionable interoperability', which we believe will require community agreement on standardization of knowledge representation that can be built on top of the shared use of ontologies

Heterogeneous biomedical database integration using a hybrid strategy: a p53 cancer research database.

Complex problems in life science research give rise to multidisciplinary collaboration, and hence, to the need for heterogeneous database integration. The tumor suppressor p53 is mutated in close to 50% of human cancers, and a small drug-like molecule with the ability to restore native function to cancerous p53 mutants is a long-held medical goal of cancer treatment. The Cancer Research DataBase (CRDB) was designed in support of a project to find such small molecules. As a cancer informatics project, the CRDB involved small molecule data, computational docking results, functional assays, and protein structure data. As an example of the hybrid strategy for data integration, it combined the mediation and data warehousing approaches. This paper uses the CRDB to illustrate the hybrid strategy as a viable approach to heterogeneous data integration in biomedicine, and provides a design method for those considering similar systems. More efficient data sharing implies increased productivity, and, hopefully, improved chances of success in cancer research. (Code and database schemas are freely downloadable, http://www.igb.uci.edu/research/research.html.)

UCTx: a multi-agent system to assist a transplant coordination unit

We present a system called UCTx, designed to model and automate some of the tasks performed by a Transplant Coordination Unit (UCTx) inside a Hospital. The aim of this work is to show how a multi-agent approach allows us to describe and implement the model, and how UCTx is capable of dealing with another multi-agent (Carrel, an Agent Mediated Institution for the exchange of Human Tissues among Hospitals for Transplantation) in order to meet its own goals, acting as the representative of the hospital in the negotiation. As an example we introduce the use of this Agency in the case of Cornea Transplantation.Postprint (published version

A framework to maximise the communicative power of knowledge visualisations

Knowledge visualisation, in the field of information systems, is both a process and a product, informed by the closely aligned fields of information visualisation and knowledg management. Knowledge visualisation has untapped potential within the purview of knowledge communication. Even so, knowledge visualisations are infrequently deployed due to a lack of evidence-based guidance. To improve this situation, we carried out a systematic literature review to derive a number of “lenses” that can be used to reveal the essential perspectives to feed into the visualisation production process.We propose a conceptual framework which incorporates these lenses to guide producers of knowledge visualisations. This framework uses the different lenses to reveal critical perspectives that need to be considered during the design process. We conclude by demonstrating how this framework could be used to produce an effective knowledge visualisation