Gene function finding through cross-organism ensemble learning

Background: Structured biological information about genes and proteins is a valuable resource to improve discovery and understanding of complex biological processes via machine learning algorithms. Gene Ontology (GO) controlled annotations describe, in a structured form, features and functions of genes and proteins of many organisms. However, such valuable annotations are not always reliable and sometimes are incomplete, especially for rarely studied organisms. Here, we present GeFF (Gene Function Finder), a novel cross-organism ensemble learning method able to reliably predict new GO annotations of a target organism from GO annotations of another source organism evolutionarily related and better studied. Results: Using a supervised method, GeFF predicts unknown annotations from random perturbations of existing annotations. The perturbation consists in randomly deleting a fraction of known annotations in order to produce a reduced annotation set. The key idea is to train a supervised machine learning algorithm with the reduced annotation set to predict, namely to rebuild, the original annotations. The resulting prediction model, in addition to accurately rebuilding the original known annotations for an organism from their perturbed version, also effectively predicts new unknown annotations for the organism. Moreover, the prediction model is also able to discover new unknown annotations in different target organisms without retraining.We combined our novel method with different ensemble learning approaches and compared them to each other and to an equivalent single model technique. We tested the method with five different organisms using their GO annotations: Homo sapiens, Mus musculus, Bos taurus, Gallus gallus and Dictyostelium discoideum. The outcomes demonstrate the effectiveness of the cross-organism ensemble approach, which can be customized with a trade-off between the desired number of predicted new annotations and their precision.A Web application to browse both input annotations used and predicted ones, choosing the ensemble prediction method to use, is publicly available at http://tiny.cc/geff/. Conclusions: Our novel cross-organism ensemble learning method provides reliable predicted novel gene annotations, i.e., functions, ranked according to an associated likelihood value. They are very valuable both to speed the annotation curation, focusing it on the prioritized new annotations predicted, and to complement known annotations available

Content Recommendation Through Linked Data

Nowadays, people can easily obtain a huge amount of information from the Web, but often they have no criteria to discern it. This issue is known as information overload. Recommender systems are software tools to suggest interesting items to users and can help them to deal with a vast amount of information. Linked Data is a set of best practices to publish data on the Web, and it is the basis of the Web of Data, an interconnected global dataspace. This thesis discusses how to discover information useful for the user from the vast amount of structured data, and notably Linked Data available on the Web. The work addresses this issue by considering three research questions: how to exploit existing relationships between resources published on the Web to provide recommendations to users; how to represent the user and his context to generate better recommendations for the current situation; and how to effectively visualize the recommended resources and their relationships. To address the first question, the thesis proposes a new algorithm based on Linked Data which exploits existing relationships between resources to recommend related resources. The algorithm was integrated into a framework to deploy and evaluate Linked Data based recommendation algorithms. In fact, a related problem is how to compare them and how to evaluate their performance when applied to a given dataset. The user evaluation showed that our algorithm improves the rate of new recommendations, while maintaining a satisfying prediction accuracy. To represent the user and their context, this thesis presents the Recommender System Context ontology, which is exploited in a new context-aware approach that can be used with existing recommendation algorithms. The evaluation showed that this method can significantly improve the prediction accuracy. As regards the problem of effectively visualizing the recommended resources and their relationships, this thesis proposes a visualization framework for DBpedia (the Linked Data version of Wikipedia) and mobile devices, which is designed to be extended to other datasets. In summary, this thesis shows how it is possible to exploit structured data available on the Web to recommend useful resources to users. Linked Data were successfully exploited in recommender systems. Various proposed approaches were implemented and applied to use cases of Telecom Italia

Data and Text Mining Techniques for In-Domain and Cross-Domain Applications

In the big data era, a wide amount of data has been generated in different domains, from social media to news feeds, from health care to genomic functionalities. When addressing a problem, we usually need to harness multiple disparate datasets. Data from different domains may follow different modalities, each of which has a different representation, distribution, scale and density. For example, text is usually represented as discrete sparse word count vectors, whereas an image is represented by pixel intensities, and so on. Nowadays plenty of Data Mining and Machine Learning techniques are proposed in literature, which have already achieved significant success in many knowledge engineering areas, including classification, regression and clustering. Anyway some challenging issues remain when tackling a new problem: how to represent the problem? What approach is better to use among the huge quantity of possibilities? What is the information to be used in the Machine Learning task and how to represent it? There exist any different domains from which borrow knowledge? This dissertation proposes some possible representation approaches for problems in different domains, from text mining to genomic analysis. In particular, one of the major contributions is a different way to represent a classical classification problem: instead of using an instance related to each object (a document, or a gene, or a social post, etc.) to be classified, it is proposed to use a pair of objects or a pair object-class, using the relationship between them as label. The application of this approach is tested on both flat and hierarchical text categorization datasets, where it potentially allows the efficient addition of new categories during classification. Furthermore, the same idea is used to extract conversational threads from an unregulated pool of messages and also to classify the biomedical literature based on the genomic features treated

High-Performance Modelling and Simulation for Big Data Applications

This open access book was prepared as a Final Publication of the COST Action IC1406 “High-Performance Modelling and Simulation for Big Data Applications (cHiPSet)“ project. Long considered important pillars of the scientific method, Modelling and Simulation have evolved from traditional discrete numerical methods to complex data-intensive continuous analytical optimisations. Resolution, scale, and accuracy have become essential to predict and analyse natural and complex systems in science and engineering. When their level of abstraction raises to have a better discernment of the domain at hand, their representation gets increasingly demanding for computational and data resources. On the other hand, High Performance Computing typically entails the effective use of parallel and distributed processing units coupled with efficient storage, communication and visualisation systems to underpin complex data-intensive applications in distinct scientific and technical domains. It is then arguably required to have a seamless interaction of High Performance Computing with Modelling and Simulation in order to store, compute, analyse, and visualise large data sets in science and engineering. Funded by the European Commission, cHiPSet has provided a dynamic trans-European forum for their members and distinguished guests to openly discuss novel perspectives and topics of interests for these two communities. This cHiPSet compendium presents a set of selected case studies related to healthcare, biological data, computational advertising, multimedia, finance, bioinformatics, and telecommunications

High-Performance Modelling and Simulation for Big Data Applications

This open access book was prepared as a Final Publication of the COST Action IC1406 “High-Performance Modelling and Simulation for Big Data Applications (cHiPSet)“ project. Long considered important pillars of the scientific method, Modelling and Simulation have evolved from traditional discrete numerical methods to complex data-intensive continuous analytical optimisations. Resolution, scale, and accuracy have become essential to predict and analyse natural and complex systems in science and engineering. When their level of abstraction raises to have a better discernment of the domain at hand, their representation gets increasingly demanding for computational and data resources. On the other hand, High Performance Computing typically entails the effective use of parallel and distributed processing units coupled with efficient storage, communication and visualisation systems to underpin complex data-intensive applications in distinct scientific and technical domains. It is then arguably required to have a seamless interaction of High Performance Computing with Modelling and Simulation in order to store, compute, analyse, and visualise large data sets in science and engineering. Funded by the European Commission, cHiPSet has provided a dynamic trans-European forum for their members and distinguished guests to openly discuss novel perspectives and topics of interests for these two communities. This cHiPSet compendium presents a set of selected case studies related to healthcare, biological data, computational advertising, multimedia, finance, bioinformatics, and telecommunications

An integrated clustering analysis framework for heterogeneous data

Big data is a growing area of research with some important research challenges that motivate our work. We focus on one such challenge, the variety aspect. First, we introduce our problem by defining heterogeneous data as data about objects that are described by different data types, e.g., structured data, text, time-series, images, etc. Through our work we use five datasets for experimentation: a real dataset of prostate cancer data and four synthetic dataset that we have created and made them publicly available. Each dataset covers different combinations of data types that are used to describe objects. Our strategy for clustering is based on fusion approaches. We compare intermediate and late fusion schemes. We propose an intermediary fusion approach, Similarity Matrix Fusion (SMF), where the integration process takes place at the level of calculating similarities. SMF produces a single distance fusion matrix and two uncertainty expression matrices. We then propose a clustering algorithm, Hk-medoids, a modified version of the standard k-medoids algorithm that utilises uncertainty calculations to improve on the clustering performance. We evaluate our results by comparing them to clustering produced using individual elements and show that the fusion approach produces equal or significantly better results. Also, we show that there are advantages in utilising the uncertainty information as Hkmedoids does. In addition, from a theoretical point of view, our proposed Hk-medoids algorithm has less computation complexity than the popular PAM implementation of the k-medoids algorithm. Then, we employed late fusion that aggregates the results of clustering by individual elements by combining cluster labels using an object co-occurrence matrix technique. The final cluster is then derived by a hierarchical clustering algorithm. We show that intermediate fusion for clustering of heterogeneous data is a feasible and efficient approach using our proposed Hk-medoids algorithm

Multilingual sentiment analysis in social media.

252 p.This thesis addresses the task of analysing sentiment in messages coming from social media. The ultimate goal was to develop a Sentiment Analysis system for Basque. However, because of the socio-linguistic reality of the Basque language a tool providing only analysis for Basque would not be enough for a real world application. Thus, we set out to develop a multilingual system, including Basque, English, French and Spanish.The thesis addresses the following challenges to build such a system:- Analysing methods for creating Sentiment lexicons, suitable for less resourced languages.- Analysis of social media (specifically Twitter): Tweets pose several challenges in order to understand and extract opinions from such messages. Language identification and microtext normalization are addressed.- Research the state of the art in polarity classification, and develop a supervised classifier that is tested against well known social media benchmarks.- Develop a social media monitor capable of analysing sentiment with respect to specific events, products or organizations