Machine Learning and Integrative Analysis of Biomedical Big Data.

Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome) is analyzed in isolation using statistical and machine learning (ML) methods. Integrative analysis of multi-omics and clinical data is key to new biomedical discoveries and advancements in precision medicine. However, data integration poses new computational challenges as well as exacerbates the ones associated with single-omics studies. Specialized computational approaches are required to effectively and efficiently perform integrative analysis of biomedical data acquired from diverse modalities. In this review, we discuss state-of-the-art ML-based approaches for tackling five specific computational challenges associated with integrative analysis: curse of dimensionality, data heterogeneity, missing data, class imbalance and scalability issues

A Taxonomy of Big Data for Optimal Predictive Machine Learning and Data Mining

Big data comes in various ways, types, shapes, forms and sizes. Indeed, almost all areas of science, technology, medicine, public health, economics, business, linguistics and social science are bombarded by ever increasing flows of data begging to analyzed efficiently and effectively. In this paper, we propose a rough idea of a possible taxonomy of big data, along with some of the most commonly used tools for handling each particular category of bigness. The dimensionality p of the input space and the sample size n are usually the main ingredients in the characterization of data bigness. The specific statistical machine learning technique used to handle a particular big data set will depend on which category it falls in within the bigness taxonomy. Large p small n data sets for instance require a different set of tools from the large n small p variety. Among other tools, we discuss Preprocessing, Standardization, Imputation, Projection, Regularization, Penalization, Compression, Reduction, Selection, Kernelization, Hybridization, Parallelization, Aggregation, Randomization, Replication, Sequentialization. Indeed, it is important to emphasize right away that the so-called no free lunch theorem applies here, in the sense that there is no universally superior method that outperforms all other methods on all categories of bigness. It is also important to stress the fact that simplicity in the sense of Ockham's razor non plurality principle of parsimony tends to reign supreme when it comes to massive data. We conclude with a comparison of the predictive performance of some of the most commonly used methods on a few data sets.Comment: 18 pages, 2 figures 3 table

Cholesky-factorized sparse Kernel in support vector machines

Support Vector Machine (SVM) is one of the most powerful machine learning algorithms due to its convex optimization formulation and handling non-linear classification. However, one of its main drawbacks is the long time it takes to train large data sets. This limitation is often aroused when applying non-linear kernels (e.g. RBF Kernel) which are usually required to obtain better separation for linearly inseparable data sets. In this thesis, we study an approach that aims to speed-up the training time by combining both the better performance of RBF kernels and fast training by a linear solver, LIBLINEAR. The approach uses an RBF kernel with a sparse matrix which is factorized using Cholesky decomposition. The method is tested on large artificial and real data sets and compared to the standard RBF and linear kernels where both the accuracy and training time are reported. For most data sets, the result shows a huge training time reduction, over 90\%, whilst maintaining the accuracy

From Review to Rating: Exploring Dependency Measures for Text Classification

Various text analysis techniques exist, which attempt to uncover unstructured information from text. In this work, we explore using statistical dependence measures for textual classification, representing text as word vectors. Student satisfaction scores on a 3-point scale and their free text comments written about university subjects are used as the dataset. We have compared two textual representations: a frequency word representation and term frequency relationship to word vectors, and found that word vectors provide a greater accuracy. However, these word vectors have a large number of features which aggravates the burden of computational complexity. Thus, we explored using a non-linear dependency measure for feature selection by maximizing the dependence between the text reviews and corresponding scores. Our quantitative and qualitative analysis on a student satisfaction dataset shows that our approach achieves comparable accuracy to the full feature vector, while being an order of magnitude faster in testing. These text analysis and feature reduction techniques can be used for other textual data applications such as sentiment analysis.Comment: 8 page