Dynamic installation and automatic update of Bluetooth low energy devices in PalCom

Chronic kidney disease is becoming an increasingly common illness.The medical background for this thesis comes from the prediction that frequent monitoring of body parameters may help prevent progression of the disease. For other chronic diseases other parameters are interesting to monitor and the need is typically dynamic. This thesis presents a solution for dynamic installation of Bluetooth low energy-enabled health care devices and automatic update of such services in the PalCom middleware. PalCom is aspiring to be a helpful tool in the pursuit of improving the quality of health care and provides functionality for taking measurements at home for remote monitoring. However, as most similar systems, PalCom only allows deployment of predefined BLE devices. The contribution of this work is a solution to install BLE-enabled health care devices in PalCom on demand, as well as a solution for automatic update of these services

Developing a distributed electronic health-record store for India

The DIGHT project is addressing the problem of building a scalable and highly available information store for the Electronic Health Records (EHRs) of the over one billion citizens of India

Inverted GUI Development for IoT with Applications in E-Health

In the context of Internet of Things (IoT), the research of this dissertation is concerned with the development of applications for end-user devices, i.e. devices through which the end-user directly interacts with systems. The complexity of such applications is partly due to network intricacies, and partly because GUI (Graphical User Interface) development is generally complicated and time consuming. We employ a middleware framework called PalCom to manage the former, and focus our research on the problems of the latter, by expanding the scope of PalCom to also enable GUI development. In particular, the research goal is a more efficient GUI development approach that does not require program code to be written.To enable end-users with little or no programming experience to participate in the GUI development process, we eliminate the need for programming by introducing a new development approach. We view this approach as “inverted” in that the development focus is on presenting functionality from an application model as graphical components in a GUI, rather than on retroactively attaching functionality to manually added graphical components. The inverted GUI development approach is supported in two steps. First, we design a language for describing GUIs, and implement interpreters that communicate with remotely hosted application models and render GUI descriptions as fully functional GUIs. Second, we implement a graphical editor for developing GUIs in order to make the language more accessible.The presented solution is evaluated by its application in a number of research projects in the domain of e-health. From the GUIs developed in those projects, we conclude that the GUI language is practically viable for building full-blown, professional grade GUIs. Furthermore, the presented graphical editor is evaluated by direct comparison to a market leading product in a controlled experiment. From this, we conclude that the editor is accessible to new users, and that it can be more efficient to use than the commercial alternative

A standards-based ICT framework to enable a service-oriented approach to clinical decision support

This research provides evidence that standards based Clinical Decision Support (CDS) at the point of care is an essential ingredient of electronic healthcare service delivery. A Service Oriented Architecture (SOA) based solution is explored, that serves as a task management system to coordinate complex distributed and disparate IT systems, processes and resources (human and computer) to provide standards based CDS. This research offers a solution to the challenges in implementing computerised CDS such as integration with heterogeneous legacy systems. Reuse of components and services to reduce costs and save time. The benefits of a sharable CDS service that can be reused by different healthcare practitioners to provide collaborative patient care is demonstrated. This solution provides orchestration among different services by extracting data from sources like patient databases, clinical knowledge bases and evidence-based clinical guidelines (CGs) in order to facilitate multiple CDS requests coming from different healthcare settings. This architecture aims to aid users at different levels of Healthcare Delivery Organizations (HCOs) to maintain a CDS repository, along with monitoring and managing services, thus enabling transparency. The research employs the Design Science research methodology (DSRM) combined with The Open Group Architecture Framework (TOGAF), an open source group initiative for Enterprise Architecture Framework (EAF). DSRM’s iterative capability addresses the rapidly evolving nature of workflows in healthcare. This SOA based solution uses standards-based open source technologies and platforms, the latest healthcare standards by HL7 and OMG, Decision Support Service (DSS) and Retrieve, Update Locate Service (RLUS) standard. Combining business process management (BPM) technologies, business rules with SOA ensures the HCO’s capability to manage its processes. This architectural solution is evaluated by successfully implementing evidence based CGs at the point of care in areas such as; a) Diagnostics (Chronic Obstructive Disease), b) Urgent Referral (Lung Cancer), c) Genome testing and integration with CDS in screening (Lynch’s syndrome). In addition to medical care, the CDS solution can benefit organizational processes for collaborative care delivery by connecting patients, physicians and other associated members. This framework facilitates integration of different types of CDS ideal for the different healthcare processes, enabling sharable CDS capabilities within and across organizations

Computing Network of Diseases and Pharmacological Entities through the Integration of Distributed Literature Mining and Ontology Mapping

The proliferation of -omics (such as, Genomics, Proteomics) and -ology (such as, System Biology, Cell Biology, Pharmacology) have spawned new frontiers of research in drug discovery and personalized medicine. A vast amount (21 million) of published research results are archived in the PubMed and are continually growing in size. To improve the accessibility and utility of such a large number of literatures, it is critical to develop a suit of semantic sensitive technology that is capable of discovering knowledge and can also infer possible new relationships based on statistical co-occurrences of meaningful terms or concepts. In this context, this thesis presents a unified framework to mine a large number of literatures through the integration of latent semantic analysis (LSA) and ontology mapping. In particular, a parameter optimized, robust, scalable, and distributed LSA (DiLSA) technique was designed and implemented on a carefully selected 7.4 million PubMed records related to pharmacology. The DiLSA model was integrated with MeSH to make the model effective and efficient for a specific domain. An optimized multi-gram dictionary was customized by mapping the MeSH to build the DiLSA model. A fully integrated web-based application, called PharmNet, was developed to bridge the gap between biological knowledge and clinical practices. Preliminary analysis using the PharmNet shows an improved performance over global LSA model. A limited expert evaluation was performed to validate the retrieved results and network with biological literatures. A thorough performance evaluation and validation of results is in progress

System for activity tracking of patients with chronic kidney disease

Many people suffering from chronic kidney disease are in need of a kidney transplant. A problem in the health care is that patients cannot undergo surgery if they have too much belly fat. Regular exercise and physical activity are therefore crucial for this group of people. A project group at the Skåne University Hospital has recently been established to help patients with chronic kidney disease to lose weight. A question they asked themselves was whether it was possible to use activity tracking devices in the project. The purpose of this thesis is to design and evaluate a system that can be used to track the physical activities of the patients. The system will be built using a Sony SmartBand, a wristband collecting and analyzing data about a user’s daily activities