Capacity -based parameter optimization of bandwidth constrained CPM

Continuous phase modulation (CPM) is an attractive modulation choice for bandwidth limited systems due to its small side lobes, fast spectral decay and the ability to be noncoherently detected. Furthermore, the constant envelope property of CPM permits highly power efficient amplification. The design of bit-interleaved coded continuous phase modulation is characterized by the code rate, modulation order, modulation index, and pulse shape. This dissertation outlines a methodology for determining the optimal values of these parameters under bandwidth and receiver complexity constraints. The cost function used to drive the optimization is the information-theoretic minimum ratio of energy-per-bit to noise-spectral density found by evaluating the constrained channel capacity. The capacity can be reliably estimated using Monte Carlo integration. A search for optimal parameters is conducted over a range of coded CPM parameters, bandwidth efficiencies, and channels. Results are presented for a system employing a trellis-based coherent detector. To constrain complexity and allow any modulation index to be considered, a soft output differential phase detector has also been developed.;Building upon the capacity results, extrinsic information transfer (EXIT) charts are used to analyze a system that iterates between demodulation and decoding. Convergence thresholds are determined for the iterative system for different outer convolutional codes, alphabet sizes, modulation indices and constellation mappings. These are used to identify the code and modulation parameters with the best energy efficiency at different spectral efficiencies for the AWGN channel. Finally, bit error rate curves are presented to corroborate the capacity and EXIT chart designs

Understanding transcriptional regulation through computational analysis of single-cell transcriptomics

Gene expression is tightly regulated by complex transcriptional regulatory mechanisms to achieve specific expression patterns, which are essential to facilitate important biological processes such as embryonic development. Dysregulation of gene expression can lead to diseases such as cancers. A better understanding of the transcriptional regulation will therefore not only advance the understanding of fundamental biological processes, but also provide mechanistic insights into diseases. The earlier versions of high-throughput expression profiling techniques were limited to measuring average gene expression across large pools of cells. In contrast, recent technological improvements have made it possible to perform expression profiling in single cells. Single-cell expression profiling is able to capture heterogeneity among single cells, which is not possible in conventional bulk expression profiling. In my PhD, I focus on developing new algorithms, as well as benchmarking and utilising existing algorithms to study the transcriptomes of various biological systems using single-cell expression data. I have developed two different single-cell specific network inference algorithms, BTR and SPVAR, which are based on two different formalisms, Boolean and autoregression frameworks respectively. BTR was shown to be useful for improving existing Boolean models with single-cell expression data, while SPVAR was shown to be a conservative predictor of gene interactions using pseudotime-ordered single-cell expression data. In addition, I have obtained novel biological insights by analysing single-cell RNAseq data from the epiblast stem cells reprogramming and the leukaemia systems. Three different driver genes, namely Esrrb, Klf2 and GY118F, were shown to drive reprogramming of epiblast stem cells via different reprogramming routes. As for the leukaemia system, FLT3-ITD and IDH1-R132H mutations were shown to interact with each other and potentially predispose some cells for developing acute myeloid leukaemia.Wellcome Trust and Cambridge Trus

Cartoons as interdiscourse : a quali-quantitative analysis of social representations based on collective imagination in cartoons produced after the Charlie Hebdo attack

The attacks against Charlie Hebdo in Paris at the beginning of the year 2015 urged many cartoonists – most professionals but some laymen as well – to create cartoons as a reaction to this tragedy. The main goal of this article is to show how traumatic events like this one can converge in a rather limited set of metaphors, ranging from easily recognizable topoi to rather vague interdiscourses that circulate in contemporary societies. To do so, we analyzed 450 cartoons that were produced as a reaction to the Charlie Hebdo attacks, and took a quali-quantitative approach that draws both on discourse analysis and semiotics. In this paper, we identified eight main themes and we analyzed the five ones which are anchored in collective imagination (the pen against the sword, the journalist as a modern hero, etc.). Then, we studied the cartoons at figurative, narrative and thematic levels thanks to Greimas’ model of the semiotic square. This paper shows the ways in which these cartoons build upon a memory-based network of events from the recent past (particularly 9/11), and more generally on a collective imagination which can be linked to Western values.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

TDRSS data handling and management system study. Ground station systems for data handling and relay satellite control

Results of a two-phase study of the (Data Handling and Management System DHMS) are presented. An original baseline DHMS is described. Its estimated costs are presented in detail. The DHMS automates the Tracking and Data Relay Satellite System (TDRSS) ground station's functions and handles both the forward and return link user and relay satellite data passing through the station. Direction of the DHMS is effected via a TDRSS Operations Control Central (OCC) that is remotely located. A composite ground station system, a modified DHMS (MDHMS), was conceptually developed. The MDHMS performs both the DHMS and OCC functions. Configurations and costs are presented for systems using minicomputers and midicomputers. It is concluded that a MDHMS should be configured with a combination of the two computer types. The midicomputers provide the system's organizational direction and computational power, and the minicomputers (or interface processors) perform repetitive data handling functions that relieve the midicomputers of these burdensome tasks