The Cowl - v.17 - n.2 - Oct 06, 1954

The Cowl - student newspaper of Providence College. Volume 17, Number 2 - Oct 06, 1954. 6 pages

The Cowl - v.31 -n.15 - Feb 14, 1979

The Cowl - student newspaper of Providence College. Volume 31, Number 15 - February 14, 1979. 20 pages. Note:: The volume number printed on the banner page of this issue (XXXI) duplicates the volume number for the 1968-69 academic year

Synthesis, In Silico Studies, Antiprotozoal and Cytotoxic Activities of Quinoline‐Biphenyl Hybrids

This is the pre-peer reviewed version of the following article: Synthesis, In Silico Studies, Antiprotozoal and Cytotoxic Activities of Quinoline‐Biphenyl Hybrids, which has been published in final form at https://doi.org/10.1002/slct.201903835. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived VersionsThe synthesis, in silico studies, antiprotozoal and cytotoxic activities of eleven quinoline‐biphenyl hybrids are described herein. The structure of the synthesized products was elucidated by a combination of spectrometric analyses. The synthesized compounds were evaluated against Plasmodium falciparum, and amastigotes forms both Leishmania (V) panamensis and Trypanosoma cruzi. Cytotoxicity was evaluated against human U‐937 macrophages. 8‐phenylquinoline (4 a) showed similar activity than meglumine antimoniate and 4‐(quinolin‐8‐yl)phenol (4 b) exhibited an activity similar to that of benznidazole. 8‐(3,4‐dimethoxyphenyl) quinoline (4 k) showed the best activity against P. falciparum. Although these compounds were toxic for mammalian U‐937 cells, however they may still have potential to be considered as candidates for drug development because of their antiparasite activity. Molecular docking was used to determine the in silico inhibition of some of the designed compounds against PfLDH and cruzipain, two important pharmacological targets involved in antiparasitic diseases. All hybrids were docked to the three‐dimensional structures of PfLDH and T. cruzi cruzipain as enzymes using AutoDock Vina. Notably, the docking results showed that the most active compounds 4‐(quinolin‐8‐yl)phenol (4 b, CE50: 11.33 μg/mL for T. cruzi) and 8‐(3,4‐dimethoxyphenyl) quinoline (4 k, CE50: 8.84 μg/mL for P. falciparum) exhibited the highest scoring pose (−7.5 and −7.7 kcal/mol, respectively). This result shows a good correlation between the predicted scores with the experimental data profile, suggesting that these ligands could act as competitive inhibitors of PfLDH or T. cruzi cruzipain enzymes, respectively. Finally, in silico ADME studies of the quinoline hybrids showed that these novel compounds have suitable drug‐like properties, making them potentially promising agents for antiprotozoal therapy

Volume 4, Number 6 - March 1924

Volume 4, Number 6 - March 1924. Contains 38 pages including covers and advertisements. Contents Keleher, James F., St. Thomas, Teacher of Teachers O\u27Reilly, J. C., A Vindication of the Fat Man Eldy, Francis, Query Ford, Earle F. and Lynch, James H., Not in the Act Keleher, James F., Lent Barry, T. Henry, The Observer The Hotchpotch Editorials Holohan, Edward V., College Chronicle Mitchell, Joseph V., Alumni Lynch, James H., Exchange Bradley, Howard F., Athletic

The Cowl - v.19 - n.21 - May 02, 1957

The Cowl - student newspaper of Providence College. Volume 19, Number 21 - May 2, 1957. 8 pages. Note:There was no Issue No. 20 published this semester

The Cowl - v.31 - n.16 - Feb 22, 1979

The Cowl - student newspaper of Providence College. Volume 31, Number 16 - February 22, 1979. 12 pages. Note:: The volume number printed on the banner page of this issue (XXXI) duplicates the volume number for the 1968-69 academic year

The Cowl - v.9 - n.6 - Dec 14, 1946

The Cowl - student newspaper of Providence College. Volume 9, Number 6 - Dec 14, 1946. 4 pages