Subtyping somatic tinnitus: a cross-sectional UK cohort study of demographic, clinical and audiological characteristics

Somatic tinnitus is the ability to modulate the psychoacoustic features of tinnitus by somatic manoeuvres. The condition is still not fully understood and further identification of this subtype is essential, particularly for the purpose of establishing protocols for both its diagnosis and treatment. This study aimed to investigate the characteristics of somatic tinnitus within a large UK cohort using a largely unselected sample. We believe this to be relatively unique in comparison to current literature on the topic. This was investigated by using a total of 608 participant assessments from a set of recognised tinnitus and audiology measures. Results from a set of chi-square tests of association found that amongst the individuals with somatic tinnitus, a higher proportion had pulsatile tinnitus (different from heartbeat), were under the age of 40, reported variation in the loudness of their tinnitus and reported temporomandibular joint (TMJ) disorder. The same pattern of results was confirmed using a multivariate analysis of the data based on logistic regression. These findings have strong implications towards the profiling of somatic tinnitus as a distinct subtype of general tinnitus

Use of nonintrusive sensor-based information and communication technology for real-world evidence for clinical trials in dementia

Cognitive function is an important end point of treatments in dementia clinical trials. Measuring cognitive function by standardized tests, however, is biased toward highly constrained environments (such as hospitals) in selected samples. Patient-powered real-world evidence using information and communication technology devices, including environmental and wearable sensors, may help to overcome these limitations. This position paper describes current and novel information and communication technology devices and algorithms to monitor behavior and function in people with prodromal and manifest stages of dementia continuously, and discusses clinical, technological, ethical, regulatory, and user-centered requirements for collecting real-world evidence in future randomized controlled trials. Challenges of data safety, quality, and privacy and regulatory requirements need to be addressed by future smart sensor technologies. When these requirements are satisfied, these technologies will provide access to truly user relevant outcomes and broader cohorts of participants than currently sampled in clinical trials

Mixing Methods and Sciences: A Longitudinal Cross-Disciplinary Mixed Methods Study on Technology to Address Social Isolation and Loneliness in Later Life

Despite a growing interest in longitudinal mixed methods research, the literature offers few examples of complex designs. To evaluate a communication-based technology to address social isolation and loneliness in later life, we conducted two long-term studies in aged-care homes. We used a longitudinal convergent mixed methods design and a cross-disciplinary approach that employed techniques from social and computer sciences to ensure a comprehensive evaluation. While cross-disciplinary mixed methods research is also growing, a discussion of its methodological practices, challenges, and strategies is still scarce. This article contributes to mixed methods research by providing lessons learned on how cross-disciplinary mixed studies can be designed and integrated from collection to interpretation, particularly when combining convergent and longitudinal approaches. We also show the value of “design-in-action”—that is, the refinement and adjustment of techniques throughout research, as methods “talk to each other.”info:eu-repo/semantics/publishedVersio