Varieties of Exploratory Experimentation in Nanotoxicology

There has been relatively little effort to provide a systematic overview of different forms of exploratory experimentation (EE). The present paper examines the growing subdiscipline of nanotoxicology and suggests that it illustrates at least four ways that researchers can engage in EE: searching for regularities; developing new techniques, simulation models, and instrumentation; collecting and analyzing large swaths of data using new experimental strategies (e.g., computer-based simulation and “high-throughput” instrumentation); and structuring an entire disciplinary field around exploratory research agendas. In order to distinguish these and other activities more effectively, the paper proposes a taxonomy that includes three dimensions along which types of EE vary: (1) the aim of the experimental activity, (2) the role of theory in the activity, and (3) the methods or strategies employed for varying experimental parameters

A Dynamic Embedding Model of the Media Landscape

Information about world events is disseminated through a wide variety of news channels, each with specific considerations in the choice of their reporting. Although the multiplicity of these outlets should ensure a variety of viewpoints, recent reports suggest that the rising concentration of media ownership may void this assumption. This observation motivates the study of the impact of ownership on the global media landscape and its influence on the coverage the actual viewer receives. To this end, the selection of reported events has been shown to be informative about the high-level structure of the news ecosystem. However, existing methods only provide a static view into an inherently dynamic system, providing underperforming statistical models and hindering our understanding of the media landscape as a whole. In this work, we present a dynamic embedding method that learns to capture the decision process of individual news sources in their selection of reported events while also enabling the systematic detection of large-scale transformations in the media landscape over prolonged periods of time. In an experiment covering over 580M real-world event mentions, we show our approach to outperform static embedding methods in predictive terms. We demonstrate the potential of the method for news monitoring applications and investigative journalism by shedding light on important changes in programming induced by mergers and acquisitions, policy changes, or network-wide content diffusion. These findings offer evidence of strong content convergence trends inside large broadcasting groups, influencing the news ecosystem in a time of increasing media ownership concentration

Systems identification and application systems development for monitoring the physiological and health status of crewmen in space

The use of automated, analytical techniques to aid medical support teams is suggested. Recommendations are presented for characterizing crew health in terms of: (1) wholebody function including physiological, psychological and performance factors; (2) a combination of critical performance indexes which consist of multiple factors of measurable parameters; (3) specific responses to low noise level stress tests; and (4) probabilities of future performance based on present and periodic examination of past performance. A concept is proposed for a computerized real time biomedical monitoring and health care system that would have the capability to integrate monitored data, detect off-nominal conditions based on current knowledge of spaceflight responses, predict future health status, and assist in diagnosis and alternative therapies. Mathematical models could play an important role in this approach, especially when operating in a real time mode. Recommendations are presented to update the present health monitoring systems in terms of recent advances in computer technology and biomedical monitoring systems

Automated system for integration and display of physiological response data

The system analysis approach was applied in a study of physiological systems in both 1-g and weightlessness, for short and long term experiments. A whole body, algorithm developed as the first step in the construction of a total body simulation system is described and an advanced biomedical computer system concept including interactive display/command consoles is discussed. The documentation of the design specifications, design and development studies, and user's instructions (which include program listings) for these delivered end-terms; the reports on the results of many research and feasibility studies; and many subcontract reports are cited in the bibliography

An Integrated Analysis of the Physiological Effects of Space Flight: Executive Summary

A large array of models were applied in a unified manner to solve problems in space flight physiology. Mathematical simulation was used as an alternative way of looking at physiological systems and maximizing the yield from previous space flight experiments. A medical data analysis system was created which consist of an automated data base, a computerized biostatistical and data analysis system, and a set of simulation models of physiological systems. Five basic models were employed: (1) a pulsatile cardiovascular model; (2) a respiratory model; (3) a thermoregulatory model; (4) a circulatory, fluid, and electrolyte balance model; and (5) an erythropoiesis regulatory model. Algorithms were provided to perform routine statistical tests, multivariate analysis, nonlinear regression analysis, and autocorrelation analysis. Special purpose programs were prepared for rank correlation, factor analysis, and the integration of the metabolic balance data

An integrative approach to space-flight physiology using systems analysis and mathematical simulation

An approach was developed to aid in the integration of many of the biomedical findings of space flight, using systems analysis. The mathematical tools used in accomplishing this task include an automated data base, a biostatistical and data analysis system, and a wide variety of mathematical simulation models of physiological systems. A keystone of this effort was the evaluation of physiological hypotheses using the simulation models and the prediction of the consequences of these hypotheses on many physiological quantities, some of which were not amenable to direct measurement. This approach led to improvements in the model, refinements of the hypotheses, a tentative integrated hypothesis for adaptation to weightlessness, and specific recommendations for new flight experiments

The Predictive Validity of the AFIT Graduate Management Program Admission Requirements: a Reassessment and Extension

This research is based on the Air Force and AFIT balancing mission requirements of personnel needed for duty and training airmen in advanced studies. Currently, over 50% of AFIT students do not meet AFIT entrance requirements. The purpose of this research was to examine criteria to determine its predictability of graduate success, as measured by graduate GPA, as well as determine whether performance is different for students who require criteria to be waived. Current AFIT eligibility criteria include undergraduate GPA, GRE test scores, or GMAT test scores. Other variables examined in this study include: GRE-Analytical test scores; rank/grade; prior enlistment; AFSC; gender; and number of members in household. This research found GMAT scores were a better predictor of success than GRE scores for management students. GRE-Q scores were good predictors for all students, while GRE-V scores were moderately good predictors for management students only. GRE-A scores should be added as a requirement with an appropriate standard. Undergraduate GPAs should be used as a guideline, not eligibility criteria into AFIT. Waivers should not be given for multiple deficiencies when possible, though there was little difference in the performance of students who met the criteria and those who did not. There was also little difference in the performance of students depending upon the type of waiver given