A 16 x 16 CMOS amperometric microelectrode array for simultaneous electrochemical measurements

There is a requirement for an electrochemical sensor technology capable of making multivariate measurements in environmental, healthcare, and manufacturing applications. Here, we present a new device that is highly parallelized with an excellent bandwidth. For the first time, electrochemical cross-talk for a chip-based sensor is defined and characterized. The new CMOS electrochemical sensor chip is capable of simultaneously taking multiple, independent electroanalytical measurements. The chip is structured as an electrochemical cell microarray, comprised of a microelectrode array connected to embedded self-contained potentiostats. Speed and sensitivity are essential in dynamic variable electrochemical systems. Owing to the parallel function of the system, rapid data collection is possible while maintaining an appropriately low-scan rate. By performing multiple, simultaneous cyclic voltammetry scans in each of the electrochemical cells on the chip surface, we are able to show (with a cell-to-cell pitch of 456 μm) that the signal cross-talk is only 12% between nearest neighbors in a ferrocene rich solution. The system opens up the possibility to use multiple independently controlled electrochemical sensors on a single chip for applications in DNA sensing, medical diagnostics, environmental sensing, the food industry, neuronal sensing, and drug discovery

Detecting Targets above the Earth's Surface Using GNSS-R Delay Doppler Maps: Results from TDS-1

: Global Navigation Satellite System (GNSS) reflected signals can be used to remotely sense the Earth’s surface, known as GNSS reflectometry (GNSS-R). The GNSS-R technique has been applied to numerous areas, such as the retrieval of wind speed, and the detection of Earth surface objects. This work proposes a new application of GNSS-R, namely to detect objects above the Earth’s surface, such as low Earth orbit (LEO) satellites. To discuss its feasibility, 14 delay Doppler maps (DDMs) are first presented which contain unusually bright reflected signals as delays shorter than the specular reflection point over the Earth’s surface. Then, seven possible causes of these anomalies are analysed, reaching the conclusion that the anomalies are likely due to the signals being reflected from objects above the Earth’s surface. Next, the positions of the objects are calculated using the delay and Doppler information, and an appropriate geometry assumption. After that, suspect satellite objects are searched in the satellite database from Union of Concerned Scientists (UCS). Finally, three objects have been found to match the delay and Doppler conditions. In the absence of other reasons for these anomalies, GNSS-R could potentially be used to detect some objects above the Earth’s surface.Peer ReviewedPostprint (published version

Relative entropy and the multi-variable multi-dimensional moment problem

Entropy-like functionals on operator algebras have been studied since the pioneering work of von Neumann, Umegaki, Lindblad, and Lieb. The most well-known are the von Neumann entropy $trace (\rho\log \rho)$ and a generalization of the Kullback-Leibler distance $trace (\rho \log \rho - \rho \log \sigma)$, refered to as quantum relative entropy and used to quantify distance between states of a quantum system. The purpose of this paper is to explore these as regularizing functionals in seeking solutions to multi-variable and multi-dimensional moment problems. It will be shown that extrema can be effectively constructed via a suitable homotopy. The homotopy approach leads naturally to a further generalization and a description of all the solutions to such moment problems. This is accomplished by a renormalization of a Riemannian metric induced by entropy functionals. As an application we discuss the inverse problem of describing power spectra which are consistent with second-order statistics, which has been the main motivation behind the present work.Comment: 24 pages, 3 figure