Update on the ICUD-SIU consultation on multi-parametric magnetic resonance imaging in localised prostate cancer

Introduction: Prostate cancer (PCa) imaging is a rapidly evolving field. Dramatic improvements in prostate MRI during the last decade will probably change the accuracy of diagnosis. This chapter reviews recent current evidence about MRI diagnostic performance and impact on PCa management. Materials and methods: The International Consultation on Urological Diseases nominated a committee to review the literature on prostate MRI. A search of the PubMed database was conducted to identify articles focussed on MP-MRI detection and staging protocols, reporting and scoring systems, the role of MP-MRI in diagnosing PCa prior to biopsy, in active surveillance, in focal therapy and in detecting local recurrence after treatment. Results: Differences in opinion were reported in the use of the strength of magnets [1.5 Tesla (T) vs. 3T] and coils. More agreement was found regarding the choice of pulse sequences; diffusion-weighted MRI (DW-MRI), dynamic contrast-enhanced MRI (DCE MRI), and/or MR spectroscopy imaging (MRSI) are recommended in addition to conventional T2-weighted anatomical sequences. In 2015, the Prostate Imaging Reporting and Data System (PI-RADS version 2) was described to standardize image acquisition and interpretation. MP-MRI improves detection of clinically significant PCa (csPCa) in the repeat biopsy setting or before the confirmatory biopsy in patients considering active surveillance. It is useful to guide focal treatment and to detect local recurrences after treatment. Its role in biopsy-naive patients or during the course of active surveillance remains debated. Conclusion: MP-MRI is increasingly used to improve detection of csPCa and for the selection of a suitable therapeutic approach

Fault diagnosis in hierarchical discrete-event system

A framework for on-line passive fault diagnosis in hierarchical discrete-event systems is proposed. In this approach, the system model is broken to simpler substructures called D-holons. A state based diagnoser is constructed for each D-holon. Fault diagnosis is accomplished using the state estimates provided by the D-holon diagnosers. The diagnosers may communicate among each other in order to update their state estimates. At any given time, only a subset of the diagnosers are active, and as a result, instead of the entire model of the system, only the models of the D-holons associated with the active diagnosers are used. Therefore, only part of the system model needs to be stored in computer Random Access Memory (RAM). This reduces RAM requirements and thus, could be useful in complex multi-phase systems. The concept of D-holon provides a suitable tool to study failure diagnosability in cases where components are active in certain phases of operation and inactive in other phases. This resulted in the introduction of the concept of phase-diagnosability. A set of necessary and sufficient conditions for phase-diagnosability is obtained. Furthermore, in order to reduce the computational complexity of the diagnosis process, a set of sufficient conditions is provided under which the diagnosis process becomes semi-modular. It is shown that the computational complexity of constructing (time) and storing (space) the transition systems required for diagnosis in the proposed semi-modular approach is polynomial in the number of system components, whereas in the original monolithic approach the computational complexity is exponential

Diagnostic Mycology Laboratories Should Have a Central Role for the Management of Fungal Disease

The absence of awareness of fungal diseases as part of the differential diagnosis in at-risk populations has severe consequences. Here, we show how the active role of laboratories can improve patients’ survival. Recently, major advances have been made in non-culture-based assays for fungal diseases, improving accuracy and turnaround time. Furthermore, with the introduction of proficiency control systems, laboratories are an easily monitored environment with good analytical accuracy. Diagnostic packages for opportunistic infections can overcome many deficiencies caused by the absence of awareness. In Guatemala, to make diagnosis accessible, we set up a diagnostic laboratory hub (DLH) providing screening for cryptococcosis, histoplasmosis and tuberculosis to a network of 13 healthcare facilities attending people living with HIV (PLWHIV). In two years, we screened 2127 newly HIV-diagnosed patients. The frequency of opportunistic infections was 21%, rising to 30.3% in patients with advanced HIV disease (<200 CD4); 8.1% of these patients had more than one infection. With the implementation of this diagnostic package, mortality decreased by 7%, a key goal of many public health interventions. Screening for serious infection in high-risk populations can partially overcome training or experiential deficiencies among clinicians for life-threatening fungal diseases.The program implemented in Guatemala was supported by Global Action for Fungal Infections and JYLAG, a charity foundation based in Switzerland (E.A. received this funding under the proposal: “Minimizing HIV deaths through rapid fungal diagnosis and better care in Guatemala”).S

Damage Tolerant Active Contro l: Concept and State of the Art

Damage tolerant active control is a new research area relating to fault tolerant control design applied to mechanical structures. It encompasses several techniques already used to design controllers and to detect and to diagnose faults, as well to monitor structural integrity. Brief reviews of the common intersections of these areas are presented, with the purpose to clarify its relations and also to justify the new controller design paradigm. Some examples help to better understand the role of the new area

Towards a synthesis of multimedia and intelligent tutoring systems : a dissertation presented in partial fulfilment of the requirements for the degree of Master of Science in Computer Science at Massey University

Multimedia is being used in almost every field. This study is about the use of multimedia in the area of intelligent tutoring systems. This project studies the advantages and disadvantages of interactive multimedia and intelligent tutoring systems, and analyses the ways of combining these technologies in search of an interesting, learnable, flexible, compelling and technology-enhanced educational tool. Educational packages need to be evaluated for effectiveness. When it comes to computer-based instruction, technical concerns such as multimedia effects are taken seriously and there is not enough emphasis on its educational value. There is not much concern about the appropriateness of the instruction method to the computer medium. This research proposes a framework for evaluating educational packages which include a number of issues. Several pieces of educational software were evaluated using this framework and Diagnosis for crop protection, a multimedia software package that aids in teaching the process of diagnosing crop problems, was selected for modification, as a practical application of the theoretical work. We studied different multimedia system development models and methodologies. We also analysed the cognitive issues and intelligent features that enhance the learnability. Finally, the appropriate intelligent features and other factors that could enhance Diagnosis for crop protection to be a more 'active knowledge constructing' environment have been identified. The current version of Diagnosis for crop protection was represented using an appropriate methodology and the proposed changes were described in detail

Adaptive Signal Processing Strategy for a Wind Farm System Fault Accommodation

In order to improve the availability of offshore wind farms, thus avoiding unplanned operation and maintenance costs, which can be high for offshore installations, the accommodation of faults in their earlier occurrence is fundamental. This paper addresses the design of an active fault tolerant control scheme that is applied to a wind park benchmark of nine wind turbines, based on their nonlinear models, as well as the wind and interactions between the wind turbines in the wind farm. Note that, due to the structure of the system and its control strategy, it can be considered as a fault tolerant cooperative control problem of an autonomous plant. The controller accommodation scheme provides the on-line estimate of the fault signals generated by nonlinear filters exploiting the nonlinear geometric approach to obtain estimates decoupled from both model uncertainty and the interactions among the turbines. This paper proposes also a data-driven approach to provide these disturbance terms in analytical forms, which are subsequently used for designing the nonlinear filters for fault estimation. This feature of the work, followed by the simpler solution relying on a data-driven approach, can represent the key point when on-line implementations are considered for a viable application of the proposed scheme

Rule Based System for Diagnosing Wireless Connection Problems Using SL5 Object

There is an increase in the use of in-door wireless networking solutions via Wi-Fi and this increase infiltrated and utilized Wi-Fi enable devices, as well as smart mobiles, games consoles, security systems, tablet PCs and smart TVs. Thus the demand on Wi-Fi connections increased rapidly. Rule Based System is an essential method in helping using the human expertise in many challenging fields. In this paper, a Rule Based System was designed and developed for diagnosing the wireless connection problems and attain a precise decision about the cause of the problem. SL5 Object expert system language was used in developing the rule based system. An Evaluation of the rule based system was carried out to test its accuracy and the results were promising

Integration of a failure monitoring within a hybrid dynamic simulation environment

The complexity and the size of the industrial chemical processes induce the monitoring of a growing number of process variables. Their knowledge is generally based on the measurements of system variables and on the physico-chemical models of the process. Nevertheless this information is imprecise because of process and measurement noise. So the research ways aim at developing new and more powerful techniques for the detection of process fault. In this work, we present a method for the fault detection based on the comparison between the real system and the reference model evolution generated by the extended Kalman filter. The reference model is simulated by the dynamic hybrid simulator, PrODHyS. It is a general object-oriented environment which provides common and reusable components designed for the development and the management of dynamic simulation of industrial systems. The use of this method is illustrated through a didactic example relating to the field of Chemical Process System Engineering

FAST : a fault detection and identification software tool

The aim of this work is to improve the reliability and safety of complex critical control systems by contributing to the systematic application of fault diagnosis. In order to ease the utilization of fault detection and isolation (FDI) tools in the industry, a systematic approach is required to allow the process engineers to analyze a system from this perspective. In this way, it should be possible to analyze this system to find if it provides the required fault diagnosis and redundancy according to the process criticality. In addition, it should be possible to evaluate what-if scenarios by slightly modifying the process (f.i. adding sensors or changing their placement) and evaluating the impact in terms of the fault diagnosis and redundancy possibilities. Hence, this work proposes an approach to analyze a process from the FDI perspective and for this purpose provides the tool FAST which covers from the analysis and design phase until the final FDI supervisor implementation in a real process. To synthesize the process information, a very simple format has been defined based on XML. This format provides the needed information to systematically perform the Structural Analysis of that process. Any process can be analyzed, the only restriction is that the models of the process components need to be available in the FAST tool. The processes are described in FAST in terms of process variables, components and relations and the tool performs the structural analysis of the process obtaining: (i) the structural matrix, (ii) the perfect matching, (iii) the analytical redundancy relations (if any) and (iv) the fault signature matrix. To aid in the analysis process, FAST can operate stand alone in simulation mode allowing the process engineer to evaluate the faults, its detectability and implement changes in the process components and topology to improve the diagnosis and redundancy capabilities. On the other hand, FAST can operate on-line connected to the process plant through an OPC interface. The OPC interface enables the possibility to connect to almost any process which features a SCADA system for supervisory control. When running in on-line mode, the process is monitored by a software agent known as the Supervisor Agent. FAST has also the capability of implementing distributed FDI using its multi-agent architecture. The tool is able to partition complex industrial processes into subsystems, identify which process variables need to be shared by each subsystem and instantiate a Supervision Agent for each of the partitioned subsystems. The Supervision Agents once instantiated will start diagnosing their local components and handle the requests to provide the variable values which FAST has identified as shared with other agents to support the distributed FDI process.Per tal de facilitar la utilització d'eines per la detecció i identificació de fallades (FDI) en la indústria, es requereix un enfocament sistemàtic per permetre als enginyers de processos analitzar un sistema des d'aquesta perspectiva. D'aquesta forma, hauria de ser possible analitzar aquest sistema per determinar si proporciona el diagnosi de fallades i la redundància d'acord amb la seva criticitat. A més, hauria de ser possible avaluar escenaris de casos modificant lleugerament el procés (per exemple afegint sensors o canviant la seva localització) i avaluant l'impacte en quant a les possibilitats de diagnosi de fallades i redundància. Per tant, aquest projecte proposa un enfocament per analitzar un procés des de la perspectiva FDI i per tal d'implementar-ho proporciona l'eina FAST la qual cobreix des de la fase d'anàlisi i disseny fins a la implementació final d'un supervisor FDI en un procés real. Per sintetitzar la informació del procés s'ha definit un format simple basat en XML. Aquest format proporciona la informació necessària per realitzar de forma sistemàtica l'Anàlisi Estructural del procés. Qualsevol procés pot ser analitzat, només hi ha la restricció de que els models dels components han d'estar disponibles en l'eina FAST. Els processos es descriuen en termes de variables de procés, components i relacions i l'eina realitza l'anàlisi estructural obtenint: (i) la matriu estructural, (ii) el Perfect Matching, (iii) les relacions de redundància analítica, si n'hi ha, i (iv) la matriu signatura de fallades. Per ajudar durant el procés d'anàlisi, FAST pot operar aïlladament en mode de simulació permetent a l'enginyer de procés avaluar fallades, la seva detectabilitat i implementar canvis en els components del procés i la topologia per tal de millorar les capacitats de diagnosi i redundància. Per altra banda, FAST pot operar en línia connectat al procés de la planta per mitjà d'una interfície OPC. La interfície OPC permet la possibilitat de connectar gairebé a qualsevol procés que inclogui un sistema SCADA per la seva supervisió. Quan funciona en mode en línia, el procés està monitoritzat per un agent software anomenat l'Agent Supervisor. Addicionalment, FAST té la capacitat d'implementar FDI de forma distribuïda utilitzant la seva arquitectura multi-agent. L'eina permet dividir sistemes industrials complexes en subsistemes, identificar quines variables de procés han de ser compartides per cada subsistema i generar una instància d'Agent Supervisor per cadascun dels subsistemes identificats. Els Agents Supervisor un cop activats, començaran diagnosticant els components locals i despatxant les peticions de valors per les variables que FAST ha identificat com compartides amb altres agents, per tal d'implementar el procés FDI de forma distribuïda.Postprint (published version

Robust Fault Diagnosis by Optimal Input Design for Self-sensing Systems

This paper presents a methodology for model based robust fault diagnosis and a methodology for input design to obtain optimal diagnosis of faults. The proposed algorithm is suitable for real time implementation. Issues of robustness are addressed for the input design and fault diagnosis methodologies. The proposed technique allows robust fault diagnosis under suitable conditions on the system uncertainty. The designed input and fault diagnosis techniques are illustrated by numerical simulation.Comment: Accepted in IFAC World Congress 201