Computerized analysis of hypomimia and hypokinetic dysarthria for improved diagnosis of Parkinson's disease

Background and Objective: An aging society requires easy-to-use approaches for diagnosis and monitoring of neurodegenerative disorders, such as Parkinson's disease (PD), so that clinicians can effectively adjust a treatment policy and improve patients' quality of life. Current methods of PD diagnosis and monitoring usually require the patients to come to a hospital, where they undergo several neurological and neuropsychological examinations. These examinations are usually time-consuming, expensive, and performed just a few times per year. Hence, this study explores the possibility of fusing computerized analysis of hypomimia and hypokinetic dysarthria (two motor symptoms manifested in the majority of PD patients) with the goal of proposing a new methodology of PD diagnosis that could be easily integrated into mHealth systems. Methods: We enrolled 73 PD patients and 46 age- and gender-matched healthy controls, who performed several speech/voice tasks while recorded by a microphone and a camera. Acoustic signals were parametrized in the fields of phonation, articulation and prosody. Video recordings of a face were analyzed in terms of facial landmarks movement. Both modalities were consequently modeled by the XGBoost algorithm. Results: The acoustic analysis enabled diagnosis of PD with 77% balanced accuracy, while in the case of the facial analysis, we observed 81% balanced accuracy. The fusion of both modalities increased the balanced accuracy to 83% (88% sensitivity and 78% specificity). The most informative speech exercise in the multimodality system turned out to be a tongue twister. Additionally, we identified muscle movements that are characteristic of hypomimia. Conclusions: The introduced methodology, which is based on the myriad of speech exercises likewise audio and video modality, allows for the detection of PD with an accuracy of up to 83%. The speech exercise - tongue twisters occurred to be the most valuable from the clinical point of view. Additionally, the clinical interpretation of the created models is illustrated. The presented computer-supported methodology could serve as an extra tool for neurologists in PD detection and the proposed potential solution of mHealth will facilitate the patient's and doctor's life.Peer reviewe

Models and Analysis of Vocal Emissions for Biomedical Applications

The MAVEBA Workshop proceedings, held on a biannual basis, collect the scientific papers presented both as oral and poster contributions, during the conference. The main subjects are: development of theoretical and mechanical models as an aid to the study of main phonatory dysfunctions, as well as the biomedical engineering methods for the analysis of voice signals and images, as a support to clinical diagnosis and classification of vocal pathologies

Models and analysis of vocal emissions for biomedical applications

This book of Proceedings collects the papers presented at the 3rd International Workshop on Models and Analysis of Vocal Emissions for Biomedical Applications, MAVEBA 2003, held 10-12 December 2003, Firenze, Italy. The workshop is organised every two years, and aims to stimulate contacts between specialists active in research and industrial developments, in the area of voice analysis for biomedical applications. The scope of the Workshop includes all aspects of voice modelling and analysis, ranging from fundamental research to all kinds of biomedical applications and related established and advanced technologies

A survey on perceived speaker traits: personality, likability, pathology, and the first challenge

The INTERSPEECH 2012 Speaker Trait Challenge aimed at a unified test-bed for perceived speaker traits – the first challenge of this kind: personality in the five OCEAN personality dimensions, likability of speakers, and intelligibility of pathologic speakers. In the present article, we give a brief overview of the state-of-the-art in these three fields of research and describe the three sub-challenges in terms of the challenge conditions, the baseline results provided by the organisers, and a new openSMILE feature set, which has been used for computing the baselines and which has been provided to the participants. Furthermore, we summarise the approaches and the results presented by the participants to show the various techniques that are currently applied to solve these classification tasks

Speech Recognition

Chapters in the first part of the book cover all the essential speech processing techniques for building robust, automatic speech recognition systems: the representation for speech signals and the methods for speech-features extraction, acoustic and language modeling, efficient algorithms for searching the hypothesis space, and multimodal approaches to speech recognition. The last part of the book is devoted to other speech processing applications that can use the information from automatic speech recognition for speaker identification and tracking, for prosody modeling in emotion-detection systems and in other speech processing applications that are able to operate in real-world environments, like mobile communication services and smart homes

A Silent-Speech Interface using Electro-Optical Stomatography

Sprachtechnologie ist eine große und wachsende Industrie, die das Leben von technologieinteressierten Nutzern auf zahlreichen Wegen bereichert. Viele potenzielle Nutzer werden jedoch ausgeschlossen: Nämlich alle Sprecher, die nur schwer oder sogar gar nicht Sprache produzieren können. Silent-Speech Interfaces bieten einen Weg, mit Maschinen durch ein bequemes sprachgesteuertes Interface zu kommunizieren ohne dafür akustische Sprache zu benötigen. Sie können außerdem prinzipiell eine Ersatzstimme stellen, indem sie die intendierten Äußerungen, die der Nutzer nur still artikuliert, künstlich synthetisieren. Diese Dissertation stellt ein neues Silent-Speech Interface vor, das auf einem neu entwickelten Messsystem namens Elektro-Optischer Stomatografie und einem neuartigen parametrischen Vokaltraktmodell basiert, das die Echtzeitsynthese von Sprache basierend auf den gemessenen Daten ermöglicht. Mit der Hardware wurden Studien zur Einzelworterkennung durchgeführt, die den Stand der Technik in der intra- und inter-individuellen Genauigkeit erreichten und übertrafen. Darüber hinaus wurde eine Studie abgeschlossen, in der die Hardware zur Steuerung des Vokaltraktmodells in einer direkten Artikulation-zu-Sprache-Synthese verwendet wurde. Während die Verständlichkeit der Synthese von Vokalen sehr hoch eingeschätzt wurde, ist die Verständlichkeit von Konsonanten und kontinuierlicher Sprache sehr schlecht. Vielversprechende Möglichkeiten zur Verbesserung des Systems werden im Ausblick diskutiert.:Statement of authorship iii Abstract v List of Figures vii List of Tables xi Acronyms xiii 1. Introduction 1 1.1. The concept of a Silent-Speech Interface . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 1.2. Structure of this work . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2. Fundamentals of phonetics 7 2.1. Components of the human speech production system . . . . . . . . . . . . . . . . . . . 7 2.2. Vowel sounds . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 2.3. Consonantal sounds . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 2.4. Acoustic properties of speech sounds . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 2.5. Coarticulation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18 2.6. Phonotactics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 2.7. Summary and implications for the design of a Silent-Speech Interface (SSI) . . . . . . . 21 3. Articulatory data acquisition techniques in Silent-Speech Interfaces 25 3.1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 3.2. Scope of the literature review . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 3.3. Video Recordings . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 3.4. Ultrasonography . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30 3.5. Electromyography . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34 3.6. Permanent-Magnetic Articulography . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41 3.7. Electromagnetic Articulography . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 44 3.8. Radio waves . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47 3.9. Palatography . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49 3.10.Conclusion and Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52 4. Electro-Optical Stomatography 55 4.1. Contact sensors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55 4.2. Optical distance sensors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 57 4.3. Lip sensor . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 81 4.4. Sensor Unit . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 84 4.5. Control Unit . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 89 4.6. Software . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 93 5. Articulation-to-Text 99 5.1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99 5.2. Command word recognition pilot study . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99 5.3. Command word recognition small-scale study . . . . . . . . . . . . . . . . . . . . . . . . 102 6. Articulation-to-Speech 109 6.1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 109 6.2. Articulatory synthesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 109 6.3. The six point vocal tract model . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 113 6.4. Objective evaluation of the vocal tract model . . . . . . . . . . . . . . . . . . . . . . . . 116 6.5. Perceptual evaluation of the vocal tract model . . . . . . . . . . . . . . . . . . . . . . . . 120 6.6. Direct synthesis using EOS to control the vocal tract model . . . . . . . . . . . . . . . . 125 6.7. Pitch and voicing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 132 7. Summary and outlook 145 7.1. Summary of the contributions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 145 7.2. Outlook . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 146 A. Overview of the International Phonetic Alphabet 151 B. Mathematical proofs and derivations 153 B.1. Combinatoric calculations illustrating the reduction of possible syllables using phonotactics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 153 B.2. Signal Averaging . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 155 B.3. Effect of the contact sensor area on the conductance . . . . . . . . . . . . . . . . . . . . 155 B.4. Calculation of the forward current for the OP280V diode . . . . . . . . . . . . . . . . . . 155 C. Schematics and layouts 157 C.1. Schematics of the control unit. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 158 C.2. Layout of the control unit . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 163 C.3. Bill of materials of the control unit . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 164 C.4. Schematics of the sensor unit . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 165 C.5. Layout of the sensor unit . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 166 C.6. Bill of materials of the sensor unit . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 167 D. Sensor unit assembly 169 E. Firmware flow and data protocol 177 F. Palate file format 181 G. Supplemental material regarding the vocal tract model 183 H. Articulation-to-Speech: Optimal hyperparameters 189 Bibliography 191Speech technology is a major and growing industry that enriches the lives of technologically-minded people in a number of ways. Many potential users are, however, excluded: Namely, all speakers who cannot easily or even at all produce speech. Silent-Speech Interfaces offer a way to communicate with a machine by a convenient speech recognition interface without the need for acoustic speech. They also can potentially provide a full replacement voice by synthesizing the intended utterances that are only silently articulated by the user. To that end, the speech movements need to be captured and mapped to either text or acoustic speech. This dissertation proposes a new Silent-Speech Interface based on a newly developed measurement technology called Electro-Optical Stomatography and a novel parametric vocal tract model to facilitate real-time speech synthesis based on the measured data. The hardware was used to conduct command word recognition studies reaching state-of-the-art intra- and inter-individual performance. Furthermore, a study on using the hardware to control the vocal tract model in a direct articulation-to-speech synthesis loop was also completed. While the intelligibility of synthesized vowels was high, the intelligibility of consonants and connected speech was quite poor. Promising ways to improve the system are discussed in the outlook.:Statement of authorship iii Abstract v List of Figures vii List of Tables xi Acronyms xiii 1. Introduction 1 1.1. The concept of a Silent-Speech Interface . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 1.2. Structure of this work . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2. Fundamentals of phonetics 7 2.1. Components of the human speech production system . . . . . . . . . . . . . . . . . . . 7 2.2. Vowel sounds . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 2.3. Consonantal sounds . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 2.4. Acoustic properties of speech sounds . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 2.5. Coarticulation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18 2.6. Phonotactics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 2.7. Summary and implications for the design of a Silent-Speech Interface (SSI) . . . . . . . 21 3. Articulatory data acquisition techniques in Silent-Speech Interfaces 25 3.1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 3.2. Scope of the literature review . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 3.3. Video Recordings . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 3.4. Ultrasonography . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30 3.5. Electromyography . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34 3.6. Permanent-Magnetic Articulography . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41 3.7. Electromagnetic Articulography . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 44 3.8. Radio waves . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47 3.9. Palatography . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49 3.10.Conclusion and Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52 4. Electro-Optical Stomatography 55 4.1. Contact sensors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55 4.2. Optical distance sensors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 57 4.3. Lip sensor . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 81 4.4. Sensor Unit . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 84 4.5. Control Unit . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 89 4.6. Software . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 93 5. Articulation-to-Text 99 5.1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99 5.2. Command word recognition pilot study . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99 5.3. Command word recognition small-scale study . . . . . . . . . . . . . . . . . . . . . . . . 102 6. Articulation-to-Speech 109 6.1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 109 6.2. Articulatory synthesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 109 6.3. The six point vocal tract model . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 113 6.4. Objective evaluation of the vocal tract model . . . . . . . . . . . . . . . . . . . . . . . . 116 6.5. Perceptual evaluation of the vocal tract model . . . . . . . . . . . . . . . . . . . . . . . . 120 6.6. Direct synthesis using EOS to control the vocal tract model . . . . . . . . . . . . . . . . 125 6.7. Pitch and voicing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 132 7. Summary and outlook 145 7.1. Summary of the contributions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 145 7.2. Outlook . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 146 A. Overview of the International Phonetic Alphabet 151 B. Mathematical proofs and derivations 153 B.1. Combinatoric calculations illustrating the reduction of possible syllables using phonotactics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 153 B.2. Signal Averaging . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 155 B.3. Effect of the contact sensor area on the conductance . . . . . . . . . . . . . . . . . . . . 155 B.4. Calculation of the forward current for the OP280V diode . . . . . . . . . . . . . . . . . . 155 C. Schematics and layouts 157 C.1. Schematics of the control unit. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 158 C.2. Layout of the control unit . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 163 C.3. Bill of materials of the control unit . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 164 C.4. Schematics of the sensor unit . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 165 C.5. Layout of the sensor unit . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 166 C.6. Bill of materials of the sensor unit . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 167 D. Sensor unit assembly 169 E. Firmware flow and data protocol 177 F. Palate file format 181 G. Supplemental material regarding the vocal tract model 183 H. Articulation-to-Speech: Optimal hyperparameters 189 Bibliography 19

Can humain association norm evaluate latent semantic analysis?

This paper presents the comparison of word association norm created by a psycholinguistic experiment to association lists generated by algorithms operating on text corpora. We compare lists generated by Church and Hanks algorithm and lists generated by LSA algorithm. An argument is presented on how those automatically generated lists reflect real semantic relations