Adverse Drug Event Detection, Causality Inference, Patient Communication and Translational Research

Adverse drug events (ADEs) are injuries resulting from a medical intervention related to a drug. ADEs are responsible for nearly 20% of all the adverse events that occur in hospitalized patients. ADEs have been shown to increase the cost of health care and the length of stays in hospital. Therefore, detecting and preventing ADEs for pharmacovigilance is an important task that can improve the quality of health care and reduce the cost in a hospital setting. In this dissertation, we focus on the development of ADEtector, a system that identifies ADEs and medication information from electronic medical records and the FDA Adverse Event Reporting System reports. The ADEtector system employs novel natural language processing approaches for ADE detection and provides a user interface to display ADE information. The ADEtector employs machine learning techniques to automatically processes the narrative text and identify the adverse event (AE) and medication entities that appear in that narrative text. The system will analyze the entities recognized to infer the causal relation that exists between AEs and medications by automating the elements of Naranjo score using knowledge and rule based approaches. The Naranjo Adverse Drug Reaction Probability Scale is a validated tool for finding the causality of a drug induced adverse event or ADE. The scale calculates the likelihood of an adverse event related to drugs based on a list of weighted questions. The ADEtector also presents the user with evidence for ADEs by extracting figures that contain ADE related information from biomedical literature. A brief summary is generated for each of the figures that are extracted to help users better comprehend the figure. This will further enhance the user experience in understanding the ADE information better. The ADEtector also helps patients better understand the narrative text by recognizing complex medical jargon and abbreviations that appear in the text and providing definitions and explanations for them from external knowledge resources. This system could help clinicians and researchers in discovering novel ADEs and drug relations and also hypothesize new research questions within the ADE domain

Text as Environment: A Deep Reinforcement Learning Text Readability Assessment Model

Evaluating the readability of a text can significantly facilitate the precise expression of information in a written form. The formulation of text readability assessment demands the identification of meaningful properties of the text and correct conversion of features to the right readability level. Sophisticated features and models are being used to evaluate the comprehensibility of texts accurately. Still, these models are challenging to implement, heavily language-dependent, and do not perform well on short texts. Deep reinforcement learning models are demonstrated to be helpful in further improvement of state-of-the-art text readability assessment models. The main contributions of the proposed approach are the automation of feature extraction, loosening the tight language dependency of text readability assessment task, and efficient use of text by finding the minimum portion of a text required to assess its readability. The experiments on Weebit, Cambridge Exams, and Persian readability datasets display the model's state-of-the-art precision, efficiency, and the capability to be applied to other languages.Comment: 8 pages, 2 figures, 6 equations, 7 table

A corpus based, lexical analysis of patient information for radiography

Despite the importance and the ubiquity of medical patient information in many healthcare systems in the world, we know very little about the lexical characteristics of the register. We do not know how patients perceive the information in the leaflets or whether the messages are transmitted effectively and fully understood. How a medical authority instructs and obliges patients in written information is also unclear. While the number of radiographic examinations performed globally increases year on year, studies consistently show that patients lack basic knowledge regarding the commonly-performed exams and show very poor understanding of the concomitant risks associated with radiation. There is, then, a pressing need to investigate radiography patient information in order to better understand why, and where, it is less effective. This thesis applies three approaches common to the field of corpus linguistics to uncover some of the lexical characteristics of patient information for radiography. The approaches used in this thesis are a keyword extraction, a lexical bundles analysis and an investigation of modal verbs used to express obligation. The findings suggest that patient information for radiography possesses characteristics more common to academic prose than conversation, although the high informational content of the register goes some way to explaining this and suggests that the reliance on these structures may, to a certain extent, be unavoidable. Results also suggest that the reliance on should to oblige and instruct is problematic as it may cause interpretation problems for certain patients, including those for whom English is not a primary language. Certain other characteristics of patient information revealed by the analyses may also cause comprehension, and while further research is needed, none of these characteristics would be evaluated as problematic by standard readability measures, furthering doubts about the suitability of such measures for the evaluation of medical information

Leveraging human-computer interaction and crowdsourcing for scholarly knowledge graph creation

The number of scholarly publications continues to grow each year, as well as the number of journals and active researchers. Therefore, methods and tools to organize scholarly knowledge are becoming increasingly important. Without such tools, it becomes increasingly difficult to conduct research in an efficient and effective manner. One of the fundamental issues scholarly communication is facing relates to the format in which the knowledge is shared. Scholarly communication relies primarily on narrative document-based formats that are specifically designed for human consumption. Machines cannot easily access and interpret such knowledge, leaving machines unable to provide powerful tools to organize scholarly knowledge effectively. In this thesis, we propose to leverage knowledge graphs to represent, curate, and use scholarly knowledge. The systematic knowledge representation leads to machine-actionable knowledge, which enables machines to process scholarly knowledge with minimal human intervention. To generate and curate the knowledge graph, we propose a machine learning assisted crowdsourcing approach, in particular Natural Language Processing (NLP). Currently, NLP techniques are not able to satisfactorily extract high-quality scholarly knowledge in an autonomous manner. With our proposed approach, we intertwine human and machine intelligence, thus exploiting the strengths of both approaches. First, we discuss structured scholarly knowledge, where we present the Open Research Knowledge Graph (ORKG). Specifically, we focus on the design and development of the ORKG user interface (i.e., the frontend). One of the key challenges is to provide an interface that is powerful enough to create rich knowledge descriptions yet intuitive enough for researchers without a technical background to create such descriptions. The ORKG serves as the technical foundation for the rest of the work. Second, we focus on comparable scholarly knowledge, where we introduce the concept of ORKG comparisons. ORKG comparisons provide machine-actionable overviews of related literature in a tabular form. Also, we present a methodology to leverage existing literature reviews to populate ORKG comparisons via a human-in-the-loop approach. Additionally, we show how ORKG comparisons can be used to form ORKG SmartReviews. The SmartReviews provide dynamic literature reviews in the form of living documents. They are an attempt address the main weaknesses of the current literature review practice and outline how the future of review publishing can look like. Third, we focus designing suitable tasks to generate scholarly knowledge in a crowdsourced setting. We present an intelligent user interface that enables researchers to annotate key sentences in scholarly publications with a set of discourse classes. During this process, researchers are assisted by suggestions coming from NLP tools. In addition, we present an approach to validate NLP-generated statements using microtasks in a crowdsourced setting. With this approach, we lower the barrier to entering data in the ORKG and transform content consumers into content creators. With the work presented, we strive to transform scholarly communication to improve machine-actionability of scholarly knowledge. The approaches and tools are deployed in a production environment. As a result, the majority of the presented approaches and tools are currently in active use by various research communities and already have an impact on scholarly communication.Die Zahl der wissenschaftlichen Veröffentlichungen nimmt jedes Jahr weiter zu, ebenso wie die Zahl der Zeitschriften und der aktiven Forscher. Daher werden Methoden und Werkzeuge zur Organisation von wissenschaftlichem Wissen immer wichtiger. Ohne solche Werkzeuge wird es immer schwieriger, Forschung effizient und effektiv zu betreiben. Eines der grundlegenden Probleme, mit denen die wissenschaftliche Kommunikation konfrontiert ist, betrifft das Format, in dem das Wissen publiziert wird. Die wissenschaftliche Kommunikation beruht in erster Linie auf narrativen, dokumentenbasierten Formaten, die speziell für Experten konzipiert sind. Maschinen können auf dieses Wissen nicht ohne weiteres zugreifen und es interpretieren, so dass Maschinen nicht in der Lage sind, leistungsfähige Werkzeuge zur effektiven Organisation von wissenschaftlichem Wissen bereitzustellen. In dieser Arbeit schlagen wir vor, Wissensgraphen zu nutzen, um wissenschaftliches Wissen darzustellen, zu kuratieren und zu nutzen. Die systematische Wissensrepräsentation führt zu maschinenverarbeitbarem Wissen. Dieses ermöglicht es Maschinen wissenschaftliches Wissen mit minimalem menschlichen Eingriff zu verarbeiten. Um den Wissensgraphen zu generieren und zu kuratieren, schlagen wir einen Crowdsourcing-Ansatz vor, der durch maschinelles Lernen unterstützt wird, insbesondere durch natürliche Sprachverarbeitung (NLP). Derzeit sind NLP-Techniken nicht in der Lage, qualitativ hochwertiges wissenschaftliches Wissen auf autonome Weise zu extrahieren. Mit unserem vorgeschlagenen Ansatz verknüpfen wir menschliche und maschinelle Intelligenz und nutzen so die Stärken beider Ansätze. Zunächst erörtern wir strukturiertes wissenschaftliches Wissen, wobei wir den Open Research Knowledge Graph (ORKG) vorstellen.Insbesondere konzentrieren wir uns auf das Design und die Entwicklung der ORKG-Benutzeroberfläche (das Frontend). Eine der größten Herausforderungen besteht darin, eine Schnittstelle bereitzustellen, die leistungsfähig genug ist, um umfangreiche Wissensbeschreibungen zu erstellen und gleichzeitig intuitiv genug ist für Forscher ohne technischen Hintergrund, um solche Beschreibungen zu erstellen. Der ORKG dient als technische Grundlage für die Arbeit. Zweitens konzentrieren wir uns auf vergleichbares wissenschaftliches Wissen, wofür wir das Konzept der ORKG-Vergleiche einführen. ORKG-Vergleiche bieten maschinell verwertbare Übersichten über verwandtes wissenschaftliches Wissen in tabellarischer Form. Außerdem stellen wir eine Methode vor, mit der vorhandene Literaturübersichten genutzt werden können, um ORKG-Vergleiche mit Hilfe eines Human-in-the-Loop-Ansatzes zu erstellen. Darüber hinaus zeigen wir, wie ORKG-Vergleiche verwendet werden können, um ORKG SmartReviews zu erstellen. Die SmartReviews bieten dynamische Literaturübersichten in Form von lebenden Dokumenten. Sie stellen einen Versuch dar, die Hauptschwächen der gegenwärtigen Praxis des Literaturreviews zu beheben und zu skizzieren, wie die Zukunft der Veröffentlichung von Reviews aussehen kann. Drittens konzentrieren wir uns auf die Gestaltung geeigneter Aufgaben zur Generierung von wissenschaftlichem Wissen in einer Crowdsourced-Umgebung. Wir stellen eine intelligente Benutzeroberfläche vor, die es Forschern ermöglicht, Schlüsselsätze in wissenschaftlichen Publikationen mittles Diskursklassen zu annotieren. In diesem Prozess werden Forschende mit Vorschlägen von NLP-Tools unterstützt. Darüber hinaus stellen wir einen Ansatz zur Validierung von NLP-generierten Aussagen mit Hilfe von Mikroaufgaben in einer Crowdsourced-Umgebung vor. Mit diesem Ansatz senken wir die Hürde für die Eingabe von Daten in den ORKG und setzen Inhaltskonsumenten als Inhaltsersteller ein. Mit der Arbeit streben wir eine Transformation der wissenschaftlichen Kommunikation an, um die maschinelle Verwertbarkeit von wissenschaftlichem Wissen zu verbessern. Die Ansätze und Werkzeuge werden in einer Produktionsumgebung eingesetzt. Daher werden die meisten der vorgestellten Ansätze und Werkzeuge derzeit von verschiedenen Forschungsgemeinschaften aktiv genutzt und haben bereits einen Einfluss auf die wissenschaftliche Kommunikation.EC/ERC/819536/E

JURI SAYS:An Automatic Judgement Prediction System for the European Court of Human Rights

In this paper we present the web platform JURI SAYS that automatically predicts decisions of the European Court of Human Rights based on communicated cases, which are published by the court early in the proceedings and are often available many years before the final decision is made. Our system therefore predicts future judgements of the court. The platform is available at jurisays.com and shows the predictions compared to the actual decisions of the court. It is automatically updated every month by including the prediction for the new cases. Additionally, the system highlights the sentences and paragraphs that are most important for the prediction (i.e. violation vs. no violation of human rights)

Geographic information extraction from texts

A large volume of unstructured texts, containing valuable geographic information, is available online. This information – provided implicitly or explicitly – is useful not only for scientific studies (e.g., spatial humanities) but also for many practical applications (e.g., geographic information retrieval). Although large progress has been achieved in geographic information extraction from texts, there are still unsolved challenges and issues, ranging from methods, systems, and data, to applications and privacy. Therefore, this workshop will provide a timely opportunity to discuss the recent advances, new ideas, and concepts but also identify research gaps in geographic information extraction

Representing and Redefining Specialised Knowledge: Medical Discourse

This volume brings together five selected papers on medical discourse which show how specialised medical corpora provide a framework that helps those engaging with medical discourse to determine how the everyday and the specialised combine to shape the discourse of medical professionals and non-medical communities in relation to both long and short-term factors. The papers contribute, in an exemplary way, to illustrating the shifting boundaries in today’s society between the two major poles making up the medical discourse cline: healthcare discourse at the one end, which records the demand for personalised therapies and individual medical services; and clinical discourse the other, which documents research into society’s collective medical needs

Feasibility of using citations as document summaries

The purpose of this research is to establish whether it is feasible to use citations as document summaries. People are good at creating and selecting summaries and are generally the standard for evaluating computer generated summaries. Citations can be characterized as concept symbols or short summaries of the document they are citing. Similarity metrics have been used in retrieval and text summarization to determine how alike two documents are. Similarity metrics have never been compared to what human subjects think are similar between two documents. If similarity metrics reflect human judgment, then we can mechanize the selection of citations that act as short summaries of the document they are citing. The research approach was to gather rater data comparing document abstracts to citations about the same document and then to statistically compare those results to several document metrics; frequency count, similarity metric, citation location and type of citation. There were two groups of raters, subject experts and non-experts. Both groups of raters were asked to evaluate seven parameters between abstract and citations: purpose, subject matter, methods, conclusions, findings, implications, readability, andunderstandability. The rater was to identify how strongly the citation represented the content of the abstract, on a five point likert scale. Document metrics were collected for frequency count, cosine, and similarity metric between abstracts and associated citations. In addition, data was collected on the location of the citations and the type of citation. Location was identified and dummy coded for introduction, method, discussion, review of the literature and conclusion. Citations were categorized and dummy coded for whether they refuted, noted, supported, reviewed, or applied information about the cited document. The results show there is a relationship between some similarity metrics and human judgment of similarity.Ph.D., Information Studies -- Drexel University, 200

Handbook of Easy Languages in Europe

The Handbook of Easy Languages in Europe describes what Easy Language is and how it is used in European countries. It demonstrates the great diversity of actors, instruments and outcomes related to Easy Language throughout Europe. All people, despite their limitations, have an equal right to information, inclusion, and social participation. This results in requirements for understandable language. The notion of Easy Language refers to modified forms of standard languages that aim to facilitate reading and language comprehension. This handbook describes the historical background, the principles and the practices of Easy Language in 21 European countries. Its topics include terminological definitions, legal status, stakeholders, target groups, guidelines, practical outcomes, education, research, and a reflection on future perspectives related to Easy Language in each country. Written in an academic yet interesting and understandable style, this Handbook of Easy Languages in Europe aims to find a wide audience