Construction and Verification of Performance and Reliability Models

Over the last two decades formal methods have been extended towards performance and reliability evaluation. This paper tries to provide a rather intuitive explanation of the basic concepts and features in this area. Instead of striving for mathematical rigour, the intention is to give an illustrative introduction to the basics of stochastic models, to stochastic modelling using process algebra, and to model checking as a technique to analyse stochastic models

Steps to an advanced Ada programming environment

Conceptual simplicity, tight coupling of tools, and effective support of host-target software development will characterize advanced Ada programming support environments. Several important principles have been demonstrated in the Arcturus system, including template-assisted Ada editing, command completion using Ada as a command language, and combining the advantages of interpretation and compliation. Other principles, relating to analysis, testing, and debugging of concurrent Ada programs, have appeared in other contexts. This paper discusses several of these topics, considers how they can be integrated, and argues for their inclusion in an environment appropriate for software development in the late 1980's

Engineering simulations for cancer systems biology

Computer simulation can be used to inform in vivo and in vitro experimentation, enabling rapid, low-cost hypothesis generation and directing experimental design in order to test those hypotheses. In this way, in silico models become a scientific instrument for investigation, and so should be developed to high standards, be carefully calibrated and their findings presented in such that they may be reproduced. Here, we outline a framework that supports developing simulations as scientific instruments, and we select cancer systems biology as an exemplar domain, with a particular focus on cellular signalling models. We consider the challenges of lack of data, incomplete knowledge and modelling in the context of a rapidly changing knowledge base. Our framework comprises a process to clearly separate scientific and engineering concerns in model and simulation development, and an argumentation approach to documenting models for rigorous way of recording assumptions and knowledge gaps. We propose interactive, dynamic visualisation tools to enable the biological community to interact with cellular signalling models directly for experimental design. There is a mismatch in scale between these cellular models and tissue structures that are affected by tumours, and bridging this gap requires substantial computational resource. We present concurrent programming as a technology to link scales without losing important details through model simplification. We discuss the value of combining this technology, interactive visualisation, argumentation and model separation to support development of multi-scale models that represent biologically plausible cells arranged in biologically plausible structures that model cell behaviour, interactions and response to therapeutic interventions

A general theory of action languages

We present a general theory of action-based languages as a paradigm, for the description, of those computational systems which include elements of concurrency and networking, and extend this approach to describe dist.ributed systems and also t,o describe the interaction of a system, with an environment. As part of this approach we introduce the Action Language as a common model for the class of nondeterministic concurrent programming languages and define its intensional and interaction semantics in terrors of continuous transformation of environment behavior. This semantics i.s specialized for programs with stores, and extended to describe distributed computations