BumbleKey: an interactive key for the identification of bumblebees of Italy and Corsica (Hymenoptera, Apidae)

BumbleKey is a matrix-based, interactive key to all 45 species of bumblebees of Italy and Corsica. The key allows to identify adult males and females (queens and workers) using morphological characters. The key is published online, open-access, at http://www.interactive-keys.eu/bumblekey/default.aspx

Engineering simulations for cancer systems biology

Computer simulation can be used to inform in vivo and in vitro experimentation, enabling rapid, low-cost hypothesis generation and directing experimental design in order to test those hypotheses. In this way, in silico models become a scientific instrument for investigation, and so should be developed to high standards, be carefully calibrated and their findings presented in such that they may be reproduced. Here, we outline a framework that supports developing simulations as scientific instruments, and we select cancer systems biology as an exemplar domain, with a particular focus on cellular signalling models. We consider the challenges of lack of data, incomplete knowledge and modelling in the context of a rapidly changing knowledge base. Our framework comprises a process to clearly separate scientific and engineering concerns in model and simulation development, and an argumentation approach to documenting models for rigorous way of recording assumptions and knowledge gaps. We propose interactive, dynamic visualisation tools to enable the biological community to interact with cellular signalling models directly for experimental design. There is a mismatch in scale between these cellular models and tissue structures that are affected by tumours, and bridging this gap requires substantial computational resource. We present concurrent programming as a technology to link scales without losing important details through model simplification. We discuss the value of combining this technology, interactive visualisation, argumentation and model separation to support development of multi-scale models that represent biologically plausible cells arranged in biologically plausible structures that model cell behaviour, interactions and response to therapeutic interventions

Intervention strategies for children and adolescent with disorders: from intrapsychic to transactional perspective

A large amount of studies and clinical evidence document the importance of infancy and early childhood influences on long term developmental trajectories toward mental health or psychopathology (Sameroff, 2000, 2010). Without healthy, productive adults no culture could continue to be successful. This concern is the main motivation for society to support child development research. Although the academic interests of contemporary developmental researchers range widely in cognitive and socialemotional domains, the political justification for supporting such studies is that they will lead to the understanding and ultimate prevention of behavioural problems that are costly to society. With these motivations and support, there have been major advances in our understanding of the intellectual, emotional, and social behaviour of children, adolescents and adults. This progress has forced conceptual reorientations from a unidirectionalunderstanding of development (e.g., parents affect children and not vice versa) toward a bidirectional conceptualization of development. Childrenare now assumed to affect and even select their environments as much as their environments affect their behaviour. Indeed, key among many of the most influential developmental theories in the past several decades is the assumption that children have bidirectional, or reciprocal, relationships with their environments (Bandura, 1977; Bronfenbrenner, 1979). To date, it is widely accepted that children’s healthy development is shaped by complex transactional processes among a variety of risk and protective factors, with cumulative risk factors increasing the prediction of emotional and behavioural problems (Anda et al., 2007; Rutter & Sroufe, 2000; Sameroff, 2000). Risk and protective factors include individual child characteristics such as genetic and constitutional propensities and cognitive strengths and vulnerabilities; parent characteristics such as mental health, education level, sense of efficacy, and resourcefulness; family factors such as quality of the parent-child relationship, emotional climate, and marital quality; community connectedness factors such as parental social support, social resources, and children’s peer relationships; and neighbourhood factors such as availability of resources, adequacy of housing, and levels of crime and violence (Sameroff & Fiese, 2000). The predictive value of these factors across many studies led to the development of transactional-bioecological models that attempt to conceptualize the relative contributions of proximal and distal risk and protective factors to children’s developmental outcome (Bronfenbrenner & Morris, 2006). In 1975, Sameroff and Chandler proposed the transactional model. This theoretical framework has become central to understanding the interplay between nature and nurture in explaining the development of positive and negative outcomes for children. The transactional model is a model of qualitative change. Sameroff asserted that the transactional model concerned qualitative rather than incremental change and that the underlying process was dialectical rather mechanistic in nature. The aim of this chapter is to explore this theoretical framework and its intervention strategies. In the first part, the transactional model will be described after a brief summary that will illustrate the transition from intrapsychic to transactional perspective. In the second part, intervention strategies for children and adolescent will be described. The attention of research on environmental risk and protective factors has fostered a more comprehensive understanding of what is necessary to improve the cognitive and social-emotional welfare of children and adolescents

Child development and the aims of road safety education

Pedestrian accidents are one of the most prominent causes of premature injury, handicap and death in the modern world. In children, the problem is so severe that pedestrian accidents are widely regarded as the most serious of all health risks facing children in developed countries. Not surprisingly, educational measures have long been advocated as a means of teaching children how to cope with traffic and substantial resources have been devoted to their development and provision. Unfortunately, there seems to be a widespread view at the present time that education has not achieved as much as had been hoped and that there may even be quite strict limits to what can be achieved through education. This would, of course, shift the emphasis away from education altogether towards engineering or urban planning measures aimed at creating an intrinsically safer environment in which the need for education might be reduced or even eliminated. However, whilst engineering measures undoubtedly have a major role to play in the effort to reduce accidents, this outlook is both overly optimistic about the benefits of engineering and overly pessimistic about the limitations of education. At the same time, a fresh analysis is clearly required both of the aims and methods of contemporary road safety education. The present report is designed to provide such an analysis and to establish a framework within which further debate and research can take place