Investigation of high bandwith biodevices for transcutaneous wireless telemetry

PhD ThesisBIODEVICE implants for telemetry are increasingly applied today in various areas applications. There are many examples such as; telemedicine, biotelemetry, health care, treatments for chronic diseases, epilepsy and blindness, all of which are using a wireless infrastructure environment. They use microelectronics technology for diagnostics or monitoring signals such as Electroencephalography or Electromyography. Conceptually the biodevices are defined as one of these technologies combined with transcutaneous wireless implant telemetry (TWIT). A wireless inductive coupling link is a common way for transferring the RF power and data, to communicate between a reader and a battery-less implant. Demand for higher data rate for the acquisition data returned from the body is increasing, and requires an efficient modulator to achieve high transfer rate and low power consumption. In such applications, Quadrature Phase Shift Keying (QPSK) modulation has advantages over other schemes, and double the symbol rate with respect to Binary Phase Shift Keying (BPSK) over the same spectrum band. In contrast to analogue modulators for generating QPSK signals, where the circuit complexity and power dissipation are unsuitable for medical purposes, a digital approach has advantages. Eventually a simple design can be achieved by mixing the hardware and software to minimize size and power consumption for implantable telemetry applications. This work proposes a new approach to digital modulator techniques, applied to transcutaneous implantable telemetry applications; inherently increasing the data rate and simplifying the hardware design. A novel design for a QPSK VHDL modulator to convey a high data rate is demonstrated. Essentially, CPLD/FPGA technology is used to generate hardware from VHDL code, and implement the device which performs the modulation. This improves the data transmission rate between the reader and biodevice. This type of modulator provides digital synthesis and the flexibility to reconfigure and upgrade with the two most often languages used being VHDL and Verilog (IEEE Standard) being used as hardware structure description languages. The second objective of this thesis is to improve the wireless coupling power (WCP). An efficient power amplifier was developed and a new algorithm developed for auto-power control design at the reader unit, which monitors the implant device and keeps the device working within the safety regulation power limits (SAR). The proposed system design has also been modeled and simulated with MATLAB/Simulink to validate the modulator and examine the performance of the proposed modulator in relation to its specifications.Higher Education Ministry in Liby

NATURE-INSPIRED MATERIAL STRATEGIES TOWARDS FUNCTIONAL DEVICES

Naturally sourced, renewable biomaterials possess outstanding advantages for a multitude of biomedical applications owing to their biodegradability, biocompatibility, and excellent mechanical properties. Of interest in this dissertation are silk (protein) and chitin (polysaccharide) biopolymers for the fabrication of functional biodevices. One of the major challenges restricting these materials beyond their traditional usage as passive substrate materials is the ability to combine them with high-resolution fabrication techniques. Initial research work is directed towards the fabrication of micropatterned, flexible 2D substrates of silk fibroin and chitin using bench-top photolithographic techniques. Research is focused on imparting electrochemical properties to silk proteins using conducting polymers (PEDOT: PSS and PANI) and a naturally occurring semiconductor, eumelanin. The utility of conducting biomimetic composites in device applications was demonstrated by the fabrication of fully organic silk based flexible electrochemical biosensors. The biosensors display excellent detection of dopamine and ascorbic acid with high sensitivity. A flexible silk-PEDOT: PSS based temperature sensor is also demonstrated for the accurate monitoring of skin surface temperature. Finally, the challenge of conformability at the biological interface is addressed using structure-based design strategies. Inspiration from the Japanese art of paper cutting was taken for the formation of patterned cuts on silk fibroin films using photolithography. Micropatterned cuts can increase the conformability of films to soft biological interfaces by enhancing their strain tolerance. By doping with polyaniline (PANI), flexible, intrinsically conductive silk kirigami sheets could be fabricated. Such systems have potential in personalized healthcare monitoring devices, improving efficient disease detection and diagnosis

Lab-on-PCB Devices

Lab-on-PCB devices can be considered an emerging technology. In fact, most of the contributions have been published during the last 5 years. It is mainly focussed on both biomedical and electronic applications. The book includes an interesting guide for using the different layers of the Printed Circuit Boards for developing new devices; guidelines for fabricating PCB-based electrochemical biosensors, and an overview of fluid manipulation devices fabricated using Printed Circuit Boards. In addition, current PCB-based devices are reported, and studies for several aspects of research and development of lab-on-PCB devices are described

Advance Nanomaterials for Biosensors

The book provides a comprehensive overview of nanostructures and methods used to design biosensors, as well as applications for these biosensor nanotechnologies in the biological, chemical, and environmental monitoring fields. Biological sensing has proven to be an essential tool for understanding living systems, but it also has practical applications in medicine, drug discovery, food safety, environmental monitoring, defense, personal security, etc. In healthcare, advancements in telecommunications, expert systems, and distributed diagnostics are challenging current delivery models, while robust industrial sensors enable new approaches to research and development. Experts from around the world have written five articles on topics including:Diagnosing and treating intraocular cancers such as retinoblastoma; Nanomedicine in cancer management; Engineered nanomaterials in osteosarcoma diagnosis and treatment; Practical design of nanoscale devices; Detect alkaline phosphatase quantitatively in clinical diagnosis; Progress in the area of non-enzymatic sensing of dual/multi biomolecules; Developments in non-enzymatic glucose and H2O2 (NEGH) sensing; Multi-functionalized nanocarrier therapies for targeting retinoblastoma; Galactose functionalized nanocarriers; Sensing performance, electro-catalytic mechanism, and morphology and design of electrode materials; Biosensors along with their applications and the benefits of machine learning; Innovative approaches to improve the NEGH sensitivity, selectivity, and stability in real-time applications; Challenges and solutions in the field of biosensors

Stretchable Surface Electromyography Electrode Array Based on Liquid Metal and Conductive Polymer

Electromyography (EMG), the science of detecting and interpreting muscle electrical activity, plays a crucial role in clinical diagnostics and research. It enables assessment of muscle function, detection of abnormalities, and monitoring of rehabilitation progress. However, the current use of EMG devices is primarily limited to clinical settings, preventing its potential to revolutionize personal health management. If surface electromyography (sEMG) electrodes are stretchable, arrayed, reusable and able to continuously record, their applications for personal health management are broadened. Existing electrodes lack these essential features, hampering their widespread adoption. This thesis addresses these limitations by designing an adhesive dry electrode using tannic acid, polyvinyl alcohol, and PEDOT:PSS (TPP). Through meticulous optimization, TPP electrodes offer superior stretchability and adhesiveness compared to conventional Ag/AgCl electrodes. This ensures stable and long-term skin contact for recording. Furthermore, a metal-polymer electrode array patch (MEAP) is introduced, featuring liquid metal (LM) circuits and TPP electrodes. MEAPs exhibit better conformability than current commercial arrays, resulting in higher signal quality and stable recordings, even during significant skin deformations caused by muscle movements. Manufactured using scalable screen-printing, MEAPs combine stretchable materials and array architecture for real-time monitoring of muscle stress, fatigue, and tendon displacement. They hold great promise in reducing muscle and tendon injuries and enhancing performance in both daily exercise and professional sports. In addition, a pilot study compares MEAP performance in clinical electrodiagnostics with needle electrodes, demonstrating the non-invasive advantage of MEAP by successfully recording the signals from the same motor unit as the needle. These advancements position MEAP at the forefront of the EMG field, poised to drive breakthroughs in electrodiagnostics, personalized medicine, sports science, and rehabilitation

1996 Laboratory directed research and development annual report

This report summarizes progress from the Laboratory Directed Research and Development (LDRD) program during fiscal year 1996. In addition to a programmatic and financial overview, the report includes progress reports from 259 individual R&D projects in seventeen categories. The general areas of research include: engineered processes and materials; computational and information sciences; microelectronics and photonics; engineering sciences; pulsed power; advanced manufacturing technologies; biomedical engineering; energy and environmental science and technology; advanced information technologies; counterproliferation; advanced transportation; national security technology; electronics technologies; idea exploration and exploitation; production; and science at the interfaces - engineering with atoms