Automated Segmentation of Cerebral Aneurysm Using a Novel Statistical Multiresolution Approach

Cerebral Aneurysm (CA) is a vascular disease that threatens the lives of many adults. It a ects almost 1:5 - 5% of the general population. Sub- Arachnoid Hemorrhage (SAH), resulted by a ruptured CA, has high rates of morbidity and mortality. Therefore, radiologists aim to detect it and diagnose it at an early stage, by analyzing the medical images, to prevent or reduce its damages. The analysis process is traditionally done manually. However, with the emerging of the technology, Computer-Aided Diagnosis (CAD) algorithms are adopted in the clinics to overcome the traditional process disadvantages, as the dependency of the radiologist's experience, the inter and intra observation variability, the increase in the probability of error which increases consequently with the growing number of medical images to be analyzed, and the artifacts added by the medical images' acquisition methods (i.e., MRA, CTA, PET, RA, etc.) which impedes the radiologist' s work. Due to the aforementioned reasons, many research works propose di erent segmentation approaches to automate the analysis process of detecting a CA using complementary segmentation techniques; but due to the challenging task of developing a robust reproducible reliable algorithm to detect CA regardless of its shape, size, and location from a variety of the acquisition methods, a diversity of proposed and developed approaches exist which still su er from some limitations. This thesis aims to contribute in this research area by adopting two promising techniques based on the multiresolution and statistical approaches in the Two-Dimensional (2D) domain. The rst technique is the Contourlet Transform (CT), which empowers the segmentation by extracting features not apparent in the normal image scale. While the second technique is the Hidden Markov Random Field model with Expectation Maximization (HMRF-EM), which segments the image based on the relationship of the neighboring pixels in the contourlet domain. The developed algorithm reveals promising results on the four tested Three- Dimensional Rotational Angiography (3D RA) datasets, where an objective and a subjective evaluation are carried out. For the objective evaluation, six performance metrics are adopted which are: accuracy, Dice Similarity Index (DSI), False Positive Ratio (FPR), False Negative Ratio (FNR), speci city, and sensitivity. As for the subjective evaluation, one expert and four observers with some medical background are involved to assess the segmentation visually. Both evaluations compare the segmented volumes against the ground truth data

Development of medical image/video segmentation via deep learning models

Image segmentation has a critical role in medical diagnosis systems as it is mostly the initial stage, and any error would be propagated in the subsequent analysis. Certain challenges, including Irregular border, low quality of images, small Region of Interest (RoI) and complex structures such as overlapping cells in images impede the improvement of medical image analysis. Deep learning-based algorithms have recently brought superior achievements in computer vision. However, there are limitations to their application in the medical domain including data scarcity, and lack of pretrained models on medical data. This research addresses the issues that hinder the progress of deep learning methods on medical data. Firstly, the effectiveness of transfer learning from a pretrained model with dissimilar data is investigated. The model is improved by integrating feature maps from the frequency domain into the spatial feature maps of Convolutional Neural Network (CNN). Training from scratch and the challenges ahead were explored as well. The proposed model shows higher performance compared to state-of-the-art methods by %2:2 and %17 in Jaccard index for tasks of lesion segmentation and dermoscopic feature segmentation respectively. Furthermore, the proposed model benefits from significant improvement for noisy images without preprocessing stage. Early stopping and drop out layers were considered to tackle the overfitting and network hyper-parameters such as different learning rate, weight initialization, kernel size, stride and normalization techniques were investigated to enhance learning performance. In order to expand the research into video segmentation, specifically left ventricular segmentation, U-net deep architecture was modified. The small RoI and confusion between overlapped organs are big challenges in MRI segmentation. The consistent motion of LV and the continuity of neighbor frames are important features that were used in the proposed architecture. High level features including optical flow and contourlet were used to add temporal information and the RoI module to the Unet model. The proposed model surpassed the results of original Unet model for LV segmentation by a %7 increment in Jaccard index

Medical Diagnosis with Multimodal Image Fusion Techniques

Image Fusion is an effective approach utilized to draw out all the significant information from the source images, which supports experts in evaluation and quick decision making. Multi modal medical image fusion produces a composite fused image utilizing various sources to improve quality and extract complementary information. It is extremely challenging to gather every piece of information needed using just one imaging method. Therefore, images obtained from different modalities are fused Additional clinical information can be gleaned through the fusion of several types of medical image pairings. This study's main aim is to present a thorough review of medical image fusion techniques which also covers steps in fusion process, levels of fusion, various imaging modalities with their pros and cons, and  the major scientific difficulties encountered in the area of medical image fusion. This paper also summarizes the quality assessments fusion metrics. The various approaches used by image fusion algorithms that are presently available in the literature are classified into four broad categories i) Spatial fusion methods ii) Multiscale Decomposition based methods iii) Neural Network based methods and iv) Fuzzy Logic based methods. the benefits and pitfalls of the existing literature are explored and Future insights are suggested. Moreover, this study is anticipated to create a solid platform for the development of better fusion techniques in medical applications

Advancements and Breakthroughs in Ultrasound Imaging

Ultrasonic imaging is a powerful diagnostic tool available to medical practitioners, engineers and researchers today. Due to the relative safety, and the non-invasive nature, ultrasonic imaging has become one of the most rapidly advancing technologies. These rapid advances are directly related to the parallel advancements in electronics, computing, and transducer technology together with sophisticated signal processing techniques. This book focuses on state of the art developments in ultrasonic imaging applications and underlying technologies presented by leading practitioners and researchers from many parts of the world

Object detection, recognition and re-identification in video footage

There has been a significant number of security concerns in recent times; as a result, security cameras have been installed to monitor activities and to prevent crimes in most public places. These analysis are done either through video analytic or forensic analysis operations on human observations. To this end, within the research context of this thesis, a proactive machine vision based military recognition system has been developed to help monitor activities in the military environment. The proposed object detection, recognition and re-identification systems have been presented in this thesis. A novel technique for military personnel recognition is presented in this thesis. Initially the detected camouflaged personnel are segmented using a grabcut segmentation algorithm. Since in general a camouflaged personnel's uniform appears to be similar both at the top and the bottom of the body, an image patch is initially extracted from the segmented foreground image and used as the region of interest. Subsequently the colour and texture features are extracted from each patch and used for classification. A second approach for personnel recognition is proposed through the recognition of the badge on the cap of a military person. A feature matching metric based on the extracted Speed Up Robust Features (SURF) from the badge on a personnel's cap enabled the recognition of the personnel's arm of service. A state-of-the-art technique for recognising vehicle types irrespective of their view angle is also presented in this thesis. Vehicles are initially detected and segmented using a Gaussian Mixture Model (GMM) based foreground/background segmentation algorithm. A Canny Edge Detection (CED) stage, followed by morphological operations are used as pre-processing stage to help enhance foreground vehicular object detection and segmentation. Subsequently, Region, Histogram Oriented Gradient (HOG) and Local Binary Pattern (LBP) features are extracted from the refined foreground vehicle object and used as features for vehicle type recognition. Two different datasets with variant views of front/rear and angle are used and combined for testing the proposed technique. For night-time video analytics and forensics, the thesis presents a novel approach to pedestrian detection and vehicle type recognition. A novel feature acquisition technique named, CENTROG, is proposed for pedestrian detection and vehicle type recognition in this thesis. Thermal images containing pedestrians and vehicular objects are used to analyse the performance of the proposed algorithms. The video is initially segmented using a GMM based foreground object segmentation algorithm. A CED based pre-processing step is used to enhance segmentation accuracy prior using Census Transforms for initial feature extraction. HOG features are then extracted from the Census transformed images and used for detection and recognition respectively of human and vehicular objects in thermal images. Finally, a novel technique for people re-identification is proposed in this thesis based on using low-level colour features and mid-level attributes. The low-level colour histogram bin values were normalised to 0 and 1. A publicly available dataset (VIPeR) and a self constructed dataset have been used in the experiments conducted with 7 clothing attributes and low-level colour histogram features. These 7 attributes are detected using features extracted from 5 different regions of a detected human object using an SVM classifier. The low-level colour features were extracted from the regions of a detected human object. These 5 regions are obtained by human object segmentation and subsequent body part sub-division. People are re-identified by computing the Euclidean distance between a probe and the gallery image sets. The experiments conducted using SVM classifier and Euclidean distance has proven that the proposed techniques attained all of the aforementioned goals. The colour and texture features proposed for camouflage military personnel recognition surpasses the state-of-the-art methods. Similarly, experiments prove that combining features performed best when recognising vehicles in different views subsequent to initial training based on multi-views. In the same vein, the proposed CENTROG technique performed better than the state-of-the-art CENTRIST technique for both pedestrian detection and vehicle type recognition at night-time using thermal images. Finally, we show that the proposed 7 mid-level attributes and the low-level features results in improved performance accuracy for people re-identification

Deep learning for diabetic retinopathy detection and classification based on fundus images: A review.

Diabetic Retinopathy is a retina disease caused by diabetes mellitus and it is the leading cause of blindness globally. Early detection and treatment are necessary in order to delay or avoid vision deterioration and vision loss. To that end, many artificial-intelligence-powered methods have been proposed by the research community for the detection and classification of diabetic retinopathy on fundus retina images. This review article provides a thorough analysis of the use of deep learning methods at the various steps of the diabetic retinopathy detection pipeline based on fundus images. We discuss several aspects of that pipeline, ranging from the datasets that are widely used by the research community, the preprocessing techniques employed and how these accelerate and improve the models' performance, to the development of such deep learning models for the diagnosis and grading of the disease as well as the localization of the disease's lesions. We also discuss certain models that have been applied in real clinical settings. Finally, we conclude with some important insights and provide future research directions

High performance computing for 3D image segmentation

Digital image processing is a very popular and still very promising eld of science, which has been successfully applied to numerous areas and problems, reaching elds like forensic analysis, security systems, multimedia processing, aerospace, automotive, and many more. A very important part of the image processing area is image segmentation. This refers to the task of partitioning a given image into multiple regions and is typically used to locate and mark objects and boundaries in input scenes. After segmentation the image represents a set of data far more suitable for further algorithmic processing and decision making. Image segmentation algorithms are a very broad eld and they have received signi cant amount of research interest A good example of an area, in which image processing plays a constantly growing role, is the eld of medical solutions. The expectations and demands that are presented in this branch of science are very high and dif cult to meet for the applied technology. The problems are challenging and the potential bene ts are signi cant and clearly visible. For over thirty years image processing has been applied to different problems and questions in medicine and the practitioners have exploited the rich possibilities that it offered. As a result, the eld of medicine has seen signi cant improvements in the interpretation of examined medical data. Clearly, the medical knowledge has also evolved signi cantly over these years, as well as the medical equipment that serves doctors and researchers. Also the common computer hardware, which is present at homes, of ces and laboratories, is constantly evolving and changing. All of these factors have sculptured the shape of modern image processing techniques and established in which ways it is currently used and developed. Modern medical image processing is centered around 3D images with high spatial and temporal resolution, which can bring a tremendous amount of data for medical practitioners. Processing of such large sets of data is not an easy task, requiring high computational power. Furthermore, in present times the computational power is not as easily available as in recent years, as the growth of possibilities of a single processing unit is very limited - a trend towards multi-unit processing and parallelization of the workload is clearly visible. Therefore, in order to continue the development of more complex and more advanced image processing techniques, a new direction is necessary. A very interesting family of image segmentation algorithms, which has been gaining a lot of focus in the last three decades, is called Deformable Models. They are based on the concept of placing a geometrical object in the scene of interest and deforming it until it assumes the shape of objects of interest. This process is usually guided by several forces, which originate in mathematical functions, features of the input images and other constraints of the deformation process, like object curvature or continuity. A range of very desired features of Deformable Models include their high capability for customization and specialization for different tasks and also extensibility with various approaches for prior knowledge incorporation. This set of characteristics makes Deformable Models a very ef cient approach, which is capable of delivering results in competitive times and with very good quality of segmentation, robust to noisy and incomplete data. However, despite the large amount of work carried out in this area, Deformable Models still suffer from a number of drawbacks. Those that have been gaining the most focus are e.g. sensitivity to the initial position and shape of the model, sensitivity to noise in the input images and to awed input data, or the need for user supervision over the process. The work described in this thesis aims at addressing the problems of modern image segmentation, which has raised from the combination of above-mentioned factors: the signi cant growth of image volumes sizes, the growth of complexity of image processing algorithms, coupled with the change in processor development and turn towards multi-processing units instead of growing bus speeds and the number of operations per second of a single processing unit. We present our innovative model for 3D image segmentation, called the The Whole Mesh Deformation model, which holds a set of very desired features that successfully address the above-mentioned requirements. Our model has been designed speci cally for execution on parallel architectures and with the purpose of working well with very large 3D images that are created by modern medical acquisition devices. Our solution is based on Deformable Models and is characterized by a very effective and precise segmentation capability. The proposed Whole Mesh Deformation (WMD) model uses a 3D mesh instead of a contour or a surface to represent the segmented shapes of interest, which allows exploiting more information in the image and obtaining results in shorter times. The model offers a very good ability for topology changes and allows effective parallelization of work ow, which makes it a very good choice for large data-sets. In this thesis we present a precise model description, followed by experiments on arti cial images and real medical data

Digital Image Processing Applications

Digital image processing can refer to a wide variety of techniques, concepts, and applications of different types of processing for different purposes. This book provides examples of digital image processing applications and presents recent research on processing concepts and techniques. Chapters cover such topics as image processing in medical physics, binarization, video processing, and more

Recognition of Nonideal Iris Images Using Shape Guided Approach and Game Theory

Most state-of-the-art iris recognition algorithms claim to perform with a very high recognition accuracy in a strictly controlled environment. However, their recognition accuracies significantly decrease when the acquired images are affected by different noise factors including motion blur, camera diffusion, head movement, gaze direction, camera angle, reflections, contrast, luminosity, eyelid and eyelash occlusions, and problems due to contraction and dilation. The main objective of this thesis is to develop a nonideal iris recognition system by using active contour methods, Genetic Algorithms (GAs), shape guided model, Adaptive Asymmetrical Support Vector Machines (AASVMs) and Game Theory (GT). In this thesis, the proposed iris recognition method is divided into two phases: (1) cooperative iris recognition, and (2) noncooperative iris recognition. While most state-of-the-art iris recognition algorithms have focused on the preprocessing of iris images, recently, important new directions have been identified in iris biometrics research. These include optimal feature selection and iris pattern classification. In the first phase, we propose an iris recognition scheme based on GAs and asymmetrical SVMs. Instead of using the whole iris region, we elicit the iris information between the collarette and the pupil boundary to suppress the effects of eyelid and eyelash occlusions and to minimize the matching error. In the second phase, we process the nonideal iris images that are captured in unconstrained situations and those affected by several nonideal factors. The proposed noncooperative iris recognition method is further divided into three approaches. In the first approach of the second phase, we apply active contour-based curve evolution approaches to segment the inner/outer boundaries accurately from the nonideal iris images. The proposed active contour-based approaches show a reasonable performance when the iris/sclera boundary is separated by a blurred boundary. In the second approach, we describe a new iris segmentation scheme using GT to elicit iris/pupil boundary from a nonideal iris image. We apply a parallel game-theoretic decision making procedure by modifying Chakraborty and Duncan's algorithm to form a unified approach, which is robust to noise and poor localization and less affected by weak iris/sclera boundary. Finally, to further improve the segmentation performance, we propose a variational model to localize the iris region belonging to the given shape space using active contour method, a geometric shape prior and the Mumford-Shah functional. The verification and identification performance of the proposed scheme is validated using four challenging nonideal iris datasets, namely, the ICE 2005, the UBIRIS Version 1, the CASIA Version 3 Interval, and the WVU Nonideal, plus the non-homogeneous combined dataset. We have conducted several sets of experiments and finally, the proposed approach has achieved a Genuine Accept Rate (GAR) of 97.34% on the combined dataset at the fixed False Accept Rate (FAR) of 0.001% with an Equal Error Rate (EER) of 0.81%. The highest Correct Recognition Rate (CRR) obtained by the proposed iris recognition system is 97.39%