Pathophysiology, histopathology and therapeutic of SARS-CoV-2

The rapid transmission of SARS-CoV-2 through the world has induced the scientist to understand the histopathology of the virus and then to find an effective drug. However, many of the point associated with the virus pathogenicity still unknown and need more studies. In this chapter the pathophysiology, histopathology and therapeutic of SARS-CoV-2 has been reviewed. It was appeared that pathogenicity of SARS-CoV-2 is belonging to the viral with genome structure which acting by blocking the host innate immune response. Both chloroquine and hydroxyl-chloroquine have similar structure and mechanism action and they are among the most effective antiviral for treating the patents with the SARS-CoV-2. Chloroquine works by inhibition the intracellular organism by increasing the pH

Data-driven through-life costing to support product lifecycle management solutions in innovative product development

Innovative product usually refers to product that comprises of creativity and new ideas. In the development of such a new product, there is often a lack of historical knowledge and data available to be used to perform cost estimation accurately. This is due to the fact that traditional cost estimation methods are used to predict costs only after a product model has been built, and not at an early design stage when there is little data and information available. In light of this, original equipment manufacturers are also facing critical challenges of becoming globally competitive and increasing demands from customer for continuous innovation. To alleviate these situations this research has identified a new approach to cost modelling with the inclusion of product lifecycle management solutions to address innovative product development.The aim of this paper, therefore, is to discuss methods of developing an extended-enterprise data-driven through-life cost estimating method for innovative product development

Product to process lifecycle management in assembly automation systems

Presently, the automotive industry is facing enormous pressure due to global competition and ever changing legislative, economic and customer demands. Product and process development in the automotive manufacturing industry is a challenging task for many reasons. Current product life cycle management (PLM) systems tend to be product-focussed. Though, information about processes and resources are there but mostly linked to the product. Process is an important aspect, especially in assembly automation systems that link products to their manufacturing resources. This paper presents a process-centric approach to improve PLM systems in large-scale manufacturing companies, especially in the powertrain sector of the automotive industry. The idea is to integrate the information related to key engineering chains i.e. products, processes and resources based upon PLM philosophy and shift the trend of product-focussed lifecycle management to process-focussed lifecycle management, the outcome of which is the Product, Process and Resource Lifecycle Management not PLM only

An Approach to Reduce Commissioning and Ramp-up time for Multi-variant Production in Automated Production Facilities

A key requirement for future production facilities is to perform new production processes in a flexible and adaptive way with available and known resources. In this context, a comprehensive description (ontology) of involved components has a high significance. If certain technological aspects are missing during a production process, the production control should respond in a dynamic, versatile and adaptive (agile) manner to the overall value network. The possibility to describe the requirements of products for the necessary processes in the same namespace like the requirements of the necessary processes for the resources is a prerequisite to enable this behavior. Afterwards the different requirements will be placed in relation to the respective requirements. The aim is to define the necessary processes for the production based on the description of the product and the known resources in an agile way. Due to this a framework for a comprehensive description of automated production facilities, products and processes is described in this paper. The idea is that based on this framework a production facility can change the produced products without dedicated commissioning and ramp-up phases

Design of a Scalable Modular Production System for a Two-stage Food Service Franchise System

The geographically distributed production of fresh food poses unique challenges to the production system design because of their stringent industry and logistics requirements. The purpose of this research is to examine the case of a European fresh food manufacturer’s approach to introduce a scalable modular production concept for an international two‐stage gastronomy franchise system in order to identify best practice guidelines and to derive a framework for the design of distributed production systems that perform in a highly dynamic environment. The design framework was developed by creating a theoretical model through literature review and the thorough analysis of an industrial case. Information was collected through multiple site visits, workshops and semi‐structured interviews with the company’s key staff of the project, as well as examination of relevant company documentations. By means of a scenario for the Central European market, the model was reviewed in terms of its development potential and finally approved for implementation. However, research through case survey requires further empirical investigation to fully establish this approach as a valid and reliable design tool

AN INTEGRATED FRAMEWORK FOR APPLYING LEAN MANUFACTURING AND OTHER STRATEGIES IN MASS CUSTOMIZATION ENVIRONMENTS

Manufacturing organizations are facing fragmented markets and increased demand of variety from consumers. As a result, many of these firms have adopted mass customization manufacturing strategies in an effort to offer their customers the freedom of choice while maintaining operational efficiency. Lean manufacturing strategies have also seen heavy use in manufacturing environments. This study investigates the possibilities of integrating lean manufacturing principles and practices into mass customization environments in order to improve system performance. The feasibility of other manufacturing strategies such as agility, Quick Response Manufacturing and the Theory of Constraints assisting in the application of lean manufacturing for mass customization is also explored with the goal of developing a theoretical framework for the application of these manufacturing systems in different types of mass customization environments. The result of these investigations is tested and verified using a real world case study

A Seamless Convergence of the Digital and Physical Factory Aiming in Personalized Product Emergence Process (PPEP) for Smart Products within ESB Logistics Learning Factory at Reutlingen University

AbstractA seamless convergence of the digital and physical factory aiming in personalized Product Emergence Process (PPEP) for smart products within ESB Logistics Learning Factory at Reutlingen University.A completely new business model with reference to Industrie4.0 and facilitated by 3D Experience Software in today's networked society in which customers expect immediate responses, delightful experience and simple solutions is one of the mission scenarios in the ESB Logistics Learning Factory at ESB Business School (Reutlingen University).The business experience platform provides software solutions for every organization in the company respectively in the factory. An interface with dashboards, project management apps, 3D - design and construction apps with high end visualization, manufacturing and simulation apps as well as intelligence and social network apps in a collaborative interactive environment help the user to learn the creation of a value end to end process for a personalized virtual and later real produced product.Instead of traditional ways of working and a conventional operating factory real workers and robots work semi-intuitive together. Centerpiece in the self-planned interim factory is the smart personalized product, uniquely identifiable and locatable at all times during the production process – a scooter with an individual colored mobile phone – holder for any smart phone produced with a 3D printer in lot size one. Smart products have in the future solutions incorporated internet based services – designed and manufactured - at the costs of mass products. Additionally the scooter is equipped with a retrievable declarative product memory. Monitoring and control is handled by sensor tags and a raspberry positioned on the product. The engineering design and implementation of a changeable production system is guided by a self-execution system that independently find amongst others esplanade workplaces.The imparted competences to students and professionals are project management method SCRUM, customization of workflows by Industrie4.0 principles, the enhancements of products with new personalized intelligent parts, electrical and electronic self-programmed components and the control of access of the product memory information, to plan in a digital engineering environment and set up of the physical factory to produce customer orders. The gained action-orientated experience refers to the chances and requirements for holistic digital and physical systems