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    Instantaneous interactions between brain sites can distinguish movement from rest but are relatively poor at resolving different movement types

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    A Connectionist Theory of Phenomenal Experience

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    When cognitive scientists apply computational theory to the problem of phenomenal consciousness, as many of them have been doing recently, there are two fundamentally distinct approaches available. Either consciousness is to be explained in terms of the nature of the representational vehicles the brain deploys; or it is to be explained in terms of the computational processes defined over these vehicles. We call versions of these two approaches vehicle and process theories of consciousness, respectively. However, while there may be space for vehicle theories of consciousness in cognitive science, they are relatively rare. This is because of the influence exerted, on the one hand, by a large body of research which purports to show that the explicit representation of information in the brain and conscious experience are dissociable, and on the other, by the classical computational theory of mind – the theory that takes human cognition to be a species of symbol manipulation. But two recent developments in cognitive science combine to suggest that a reappraisal of this situation is in order. First, a number of theorists have recently been highly critical of the experimental methodologies employed in the dissociation studies – so critical, in fact, it’s no longer reasonable to assume that the dissociability of conscious experience and explicit representation has been adequately demonstrated. Second, classicism, as a theory of human cognition, is no longer as dominant in cognitive science as it once was. It now has a lively competitor in the form of connectionism; and connectionism, unlike classicism, does have the computational resources to support a robust vehicle theory of consciousness. In this paper we develop and defend this connectionist vehicle theory of consciousness. It takes the form of the following simple empirical hypothesis: phenomenal experience consists in the explicit representation of information in neurally realized PDP networks. This hypothesis leads us to re-assess some common wisdom about consciousness, but, we will argue, in fruitful and ultimately plausible ways

    Probabilistic Graphical Models for ERP-Based Brain Computer Interfaces

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    An event related potential (ERP) is an electrical potential recorded from the nervous system of humans or other animals. An ERP is observed after the presentation of a stimulus. Some examples of the ERPs are P300, N400, among others. Although ERPs are used very often in neuroscience, its generation is not yet well understood and different theories have been proposed to explain the phenomena. ERPs could be generated due to changes in the alpha rhythm, an internal neural control that reset the ongoing oscillations in the brain, or separate and distinct additive neuronal phenomena. When different repetitions of the same stimuli are averaged, a coherence addition of the oscillations is obtained which explain the increase in amplitude in the signals. Two ERPs are mostly studied: N400 and P300. N400 signals arise when a subject tries to make semantic operations that support neural circuits for explicit memory. N400 potentials have been observed mostly in the rhinal cortex. P300 signals are related to attention and memory operations. When a new stimulus appears, a P300 ERP (named P3a) is generated in the frontal lobe. In contrast, when a subject perceives an expected stimulus, a P300 ERP (named P3b) is generated in the temporal – parietal areas. This implicates P3a and P3b are related, suggesting a circuit pathway between the frontal and temporal–parietal regions, whose existence has not been verified. Un potencial relacionado con un evento (ERP) es un potencial eléctrico registrado en el sistema nervioso de los seres humanos u otros animales. Un ERP se observa tras la presentación de un estímulo. Aunque los ERPs se utilizan muy a menudo en neurociencia, su generación aún no se entiende bien y se han propuesto diferentes teorías para explicar el fenómeno. Una interfaz cerebro-computador (BCI) es un sistema de comunicación en el que los mensajes o las órdenes que un sujeto envía al mundo exterior proceden de algunas señales cerebrales en lugar de los nervios y músculos periféricos. La BCI utiliza ritmos sensorimotores o señales ERP, por lo que se necesita un clasificador para distinguir entre los estímulos correctos y los incorrectos. En este trabajo, proponemos utilizar modelos probabilísticos gráficos para el modelado de la dinámica temporal y espacial de las señales cerebrales con aplicaciones a las BCIs. Los modelos gráficos han sido seleccionados por su flexibilidad y capacidad de incorporar información previa. Esta flexibilidad se ha utilizado anteriormente para modelar únicamente la dinámica temporal. Esperamos que el modelo refleje algunos aspectos del funcionamiento del cerebro relacionados con los ERPs, al incluir información espacial y temporal.DoctoradoDoctor en Ingeniería Eléctrica y Electrónic

    Explaining Free Will

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    A new approach using independence indeterminism, a novel naturalistic metaphysics for an open creative universe. The problem of free will - what exactly it is, whether it is required for us to be morally responsible for our actions, and whether any natural being can possibly possess it - has remained unresolved for over 2000 years. Now, starting from the very widely held belief that most change takes place in a way that is independent of how most other change is taking place, this book builds an argument - and a novel metaphysical view dubbed "independence indeterminism" - that rapidly leads not only to a paradigm-changing way of viewing existence, but also to a new way of explaining our possession of free will. This carefully and fully argued book will be of interest to a wide readership not only because of its focus on free will but also because independence indeterminism helps resolve other long-standing issues, including why the mind is not wholly reducible to causally determined processes occurring in the brain

    Characteristics of flight simulator visual systems

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    The physical parameters of the flight simulator visual system that characterize the system and determine its fidelity are identified and defined. The characteristics of visual simulation systems are discussed in terms of the basic categories of spatial, energy, and temporal properties corresponding to the three fundamental quantities of length, mass, and time. Each of these parameters are further addressed in relation to its effect, its appropriate units or descriptors, methods of measurement, and its use or importance to image quality

    Study of cortical rhythmic activity and connectivity with magnetoencephalography

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    Intracranial recordings in animals and neuroimaging studies on humans have indicated that oscillatory activity and its modulations may play a fundamental role in large-scale neural information processing. Furthermore, rhythmic interactions between cortical areas have been detected across a variety of tasks with electroencephalography (EEG) and magnetoencephalography (MEG). This kind of coupling has been proposed to be a key mechanism through which information is integrated across segregated areas. So far, rhythmic interactions have been analyzed primarily at the EEG/MEG sensor level, without explicit knowledge of cortical areas involved. In this thesis work we developed new methods that can be used to image oscillatory activity and coherence at the cortical level with MEG. Dynamic Imaging of Coherent Sources (DICS) enables localization of interacting areas both using external reference signals and directly from the MEG data. When the interacting areas have been determined it is possible to use additional measures beyond coherence to further quantify interactions within the networks. DICS was originally designed for study of continuous data; its further development into event-related DICS (erDICS) adds the possibility to image modulations of rhythmic activity that are locked to stimulus or movement timing. Furthermore, permutation testing incorporated into erDICS allows the evaluation of the statistical significance of the results. Analysis of simulated and real data showed that DICS and erDICS yield accurate localization and quantification of oscillatory activity and coherence. Comparison of DICS to other methods of localizing oscillatory activity revealed that it is equally accurate and that it can better separate the activity originating from two nearby areas. We applied DICS to two datasets, recorded from groups of subjects while they performed slow finger movements and when they were reading continuously. In both cases, we were able to systematically identify interacting cortico-cortical networks and, using phase coupling and causality measures, to quantify the manner in which the nodes within these networks influenced each other. Furthermore, we compared the identified reading network to results reported in neurophysiological and hemodynamic activation studies. In addition to areas typically detected in activation studies of reading the network included areas that are normally found in language production rather than perception tasks, indicating more extensive networking of neural systems than usually observed in activation studies

    Wearable in-ear pulse oximetry: theory and applications

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    Wearable health technology, most commonly in the form of the smart watch, is employed by millions of users worldwide. These devices generally exploit photoplethysmography (PPG), the non-invasive use of light to measure blood volume, in order to track physiological metrics such as pulse and respiration. Moreover, PPG is commonly used in hospitals in the form of pulse oximetry, which measures light absorbance by the blood at different wavelengths of light to estimate blood oxygen levels (SpO2). This thesis aims to demonstrate that despite its widespread usage over many decades, this sensor still possesses a wealth of untapped value. Through a combination of advanced signal processing and harnessing the ear as a location for wearable sensing, this thesis introduces several novel high impact applications of in-ear pulse oximetry and photoplethysmography. The aims of this thesis are accomplished through a three pronged approach: rapid detection of hypoxia, tracking of cognitive workload and fatigue, and detection of respiratory disease. By means of the simultaneous recording of in-ear and finger pulse oximetry at rest and during breath hold tests, it was found that in-ear SpO2 responds on average 12.4 seconds faster than the finger SpO2. This is likely due in part to the ear being in close proximity to the brain, making it a priority for oxygenation and thus making wearable in-ear SpO2 a good proxy for core blood oxygen. Next, the low latency of in-ear SpO2 was further exploited in the novel application of classifying cognitive workload. It was found that in-ear pulse oximetry was able to robustly detect tiny decreases in blood oxygen during increased cognitive workload, likely caused by increased brain metabolism. This thesis demonstrates that in-ear SpO2 can be used to accurately distinguish between different levels of an N-back memory task, representing different levels of mental effort. This concept was further validated through its application to gaming and then extended to the detection of driver related fatigue. It was found that features derived from SpO2 and PPG were predictive of absolute steering wheel angle, which acts as a proxy for fatigue. The strength of in-ear PPG for the monitoring of respiration was investigated with respect to the finger, with the conclusion that in-ear PPG exhibits far stronger respiration induced intensity variations and pulse amplitude variations than the finger. All three respiratory modes were harnessed through multivariate empirical mode decomposition (MEMD) to produce spirometry-like respiratory waveforms from PPG. It was discovered that these PPG derived respiratory waveforms can be used to detect obstruction to breathing, both through a novel apparatus for the simulation of breathing disorders and through the classification of chronic obstructive pulmonary disease (COPD) in the real world. This thesis establishes in-ear pulse oximetry as a wearable technology with the potential for immense societal impact, with applications from the classification of cognitive workload and the prediction of driver fatigue, through to the detection of chronic obstructive pulmonary disease. The experiments and analysis in this thesis conclusively demonstrate that widely used pulse oximetry and photoplethysmography possess a wealth of untapped value, in essence teaching the old PPG sensor new tricks.Open Acces

    Magnetoencephalography

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    This is a practical book on MEG that covers a wide range of topics. The book begins with a series of reviews on the use of MEG for clinical applications, the study of cognitive functions in various diseases, and one chapter focusing specifically on studies of memory with MEG. There are sections with chapters that describe source localization issues, the use of beamformers and dipole source methods, as well as phase-based analyses, and a step-by-step guide to using dipoles for epilepsy spike analyses. The book ends with a section describing new innovations in MEG systems, namely an on-line real-time MEG data acquisition system, novel applications for MEG research, and a proposal for a helium re-circulation system. With such breadth of topics, there will be a chapter that is of interest to every MEG researcher or clinician

    Change blindness: eradication of gestalt strategies

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    Arrays of eight, texture-defined rectangles were used as stimuli in a one-shot change blindness (CB) task where there was a 50% chance that one rectangle would change orientation between two successive presentations separated by an interval. CB was eliminated by cueing the target rectangle in the first stimulus, reduced by cueing in the interval and unaffected by cueing in the second presentation. This supports the idea that a representation was formed that persisted through the interval before being 'overwritten' by the second presentation (Landman et al, 2003 Vision Research 43149–164]. Another possibility is that participants used some kind of grouping or Gestalt strategy. To test this we changed the spatial position of the rectangles in the second presentation by shifting them along imaginary spokes (by ±1 degree) emanating from the central fixation point. There was no significant difference seen in performance between this and the standard task [F(1,4)=2.565, p=0.185]. This may suggest two things: (i) Gestalt grouping is not used as a strategy in these tasks, and (ii) it gives further weight to the argument that objects may be stored and retrieved from a pre-attentional store during this task
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