Statistical M-Estimation and Consistency in Large Deformable Models for Image Warping

The problem of defining appropriate distances between shapes or images and modeling the variability of natural images by group transformations is at the heart of modern image analysis. A current trend is the study of probabilistic and statistical aspects of deformation models, and the development of consistent statistical procedure for the estimation of template images. In this paper, we consider a set of images randomly warped from a mean template which has to be recovered. For this, we define an appropriate statistical parametric model to generate random diffeomorphic deformations in two-dimensions. Then, we focus on the problem of estimating the mean pattern when the images are observed with noise. This problem is challenging both from a theoretical and a practical point of view. M-estimation theory enables us to build an estimator defined as a minimizer of a well-tailored empirical criterion. We prove the convergence of this estimator and propose a gradient descent algorithm to compute this M-estimator in practice. Simulations of template extraction and an application to image clustering and classification are also provided

A UNIFIED ENERGY APPROACH FOR B-SPLINE SNAKE IN MEDICAL IMAGE SEGMENTATION

 The parametric snake is one of the preferred approaches in feature extraction from images because of their simplicity and efficiency. However the method has also limitations. In this paper an explicit snake that represented using BSpline applied for image segmentation is considered. In this paper, we identify some of these problems and propose efficient solutions to get around them. The proposed method is inspired by classical snake from Kass with some adaption for parametric curve. The paper also proposes new definitions of energy terms in the model to bring the snake performance more robust and efficient for image segmentation. This energy term unify the edge based and region based energy derived from the image data. The main objective of developed work is to develop an automatic method to segment the anatomical organs from medical images which is very hard and tedious to be performed manually. After this segmentation, the anatomical object can be further measured and analyzed to diagnose the anomaly in that organ. The results have shown that the proposed method has been proven qualitatively successful in segmenting different types of medical images.

Computerized Analysis of Magnetic Resonance Images to Study Cerebral Anatomy in Developing Neonates

The study of cerebral anatomy in developing neonates is of great importance for the understanding of brain development during the early period of life. This dissertation therefore focuses on three challenges in the modelling of cerebral anatomy in neonates during brain development. The methods that have been developed all use Magnetic Resonance Images (MRI) as source data. To facilitate study of vascular development in the neonatal period, a set of image analysis algorithms are developed to automatically extract and model cerebral vessel trees. The whole process consists of cerebral vessel tracking from automatically placed seed points, vessel tree generation, and vasculature registration and matching. These algorithms have been tested on clinical Time-of- Flight (TOF) MR angiographic datasets. To facilitate study of the neonatal cortex a complete cerebral cortex segmentation and reconstruction pipeline has been developed. Segmentation of the neonatal cortex is not effectively done by existing algorithms designed for the adult brain because the contrast between grey and white matter is reversed. This causes pixels containing tissue mixtures to be incorrectly labelled by conventional methods. The neonatal cortical segmentation method that has been developed is based on a novel expectation-maximization (EM) method with explicit correction for mislabelled partial volume voxels. Based on the resulting cortical segmentation, an implicit surface evolution technique is adopted for the reconstruction of the cortex in neonates. The performance of the method is investigated by performing a detailed landmark study. To facilitate study of cortical development, a cortical surface registration algorithm for aligning the cortical surface is developed. The method first inflates extracted cortical surfaces and then performs a non-rigid surface registration using free-form deformations (FFDs) to remove residual alignment. Validation experiments using data labelled by an expert observer demonstrate that the method can capture local changes and follow the growth of specific sulcus

Efficient Dense Registration, Segmentation, and Modeling Methods for RGB-D Environment Perception

One perspective for artificial intelligence research is to build machines that perform tasks autonomously in our complex everyday environments. This setting poses challenges to the development of perception skills: A robot should be able to perceive its location and objects in its surrounding, while the objects and the robot itself could also be moving. Objects may not only be composed of rigid parts, but could be non-rigidly deformable or appear in a variety of similar shapes. Furthermore, it could be relevant to the task to observe object semantics. For a robot acting fluently and immediately, these perception challenges demand efficient methods. This theses presents novel approaches to robot perception with RGB-D sensors. It develops efficient registration, segmentation, and modeling methods for scene and object perception. We propose multi-resolution surfel maps as a concise representation for RGB-D measurements. We develop probabilistic registration methods that handle rigid scenes, scenes with multiple rigid parts that move differently, and scenes that undergo non-rigid deformations. We use these methods to learn and perceive 3D models of scenes and objects in both static and dynamic environments. For learning models of static scenes, we propose a real-time capable simultaneous localization and mapping approach. It aligns key views in RGB-D video using our rigid registration method and optimizes the pose graph of the key views. The acquired models are then perceived in live images through detection and tracking within a Bayesian filtering framework. An assumption frequently made for environment mapping is that the observed scene remains static during the mapping process. Through rigid multi-body registration, we take advantage of releasing this assumption: Our registration method segments views into parts that move independently between the views and simultaneously estimates their motion. Within simultaneous motion segmentation, localization, and mapping, we separate scenes into objects by their motion. Our approach acquires 3D models of objects and concurrently infers hierarchical part relations between them using probabilistic reasoning. It can be applied for interactive learning of objects and their part decomposition. Endowing robots with manipulation skills for a large variety of objects is a tedious endeavor if the skill is programmed for every instance of an object class. Furthermore, slight deformations of an instance could not be handled by an inflexible program. Deformable registration is useful to perceive such shape variations, e.g., between specific instances of a tool. We develop an efficient deformable registration method and apply it for the transfer of robot manipulation skills between varying object instances. On the object-class level, we segment images using random decision forest classifiers in real-time. The probabilistic labelings of individual images are fused in 3D semantic maps within a Bayesian framework. We combine our object-class segmentation method with simultaneous localization and mapping to achieve online semantic mapping in real-time. The methods developed in this thesis are evaluated in experiments on publicly available benchmark datasets and novel own datasets. We publicly demonstrate several of our perception approaches within integrated robot systems in the mobile manipulation context.Effiziente Dichte Registrierungs-, Segmentierungs- und Modellierungsmethoden für die RGB-D Umgebungswahrnehmung In dieser Arbeit beschäftigen wir uns mit Herausforderungen der visuellen Wahrnehmung für intelligente Roboter in Alltagsumgebungen. Solche Roboter sollen sich selbst in ihrer Umgebung zurechtfinden, und Wissen über den Verbleib von Objekten erwerben können. Die Schwierigkeit dieser Aufgaben erhöht sich in dynamischen Umgebungen, in denen ein Roboter die Bewegung einzelner Teile differenzieren und auch wahrnehmen muss, wie sich diese Teile bewegen. Bewegt sich ein Roboter selbständig in dieser Umgebung, muss er auch seine eigene Bewegung von der Veränderung der Umgebung unterscheiden. Szenen können sich aber nicht nur durch die Bewegung starrer Teile verändern. Auch die Teile selbst können ihre Form in nicht-rigider Weise ändern. Eine weitere Herausforderung stellt die semantische Interpretation von Szenengeometrie und -aussehen dar. Damit intelligente Roboter unmittelbar und flüssig handeln können, sind effiziente Algorithmen für diese Wahrnehmungsprobleme erforderlich. Im ersten Teil dieser Arbeit entwickeln wir effiziente Methoden zur Repräsentation und Registrierung von RGB-D Messungen. Zunächst stellen wir Multi-Resolutions-Oberflächenelement-Karten (engl. multi-resolution surfel maps, MRSMaps) als eine kompakte Repräsentation von RGB-D Messungen vor, die unseren effizienten Registrierungsmethoden zugrunde liegt. Bilder können effizient in dieser Repräsentation aggregiert werde, wobei auch mehrere Bilder aus verschiedenen Blickpunkten integriert werden können, um Modelle von Szenen und Objekte aus vielfältigen Ansichten darzustellen. Für die effiziente, robuste und genaue Registrierung von MRSMaps wird eine Methode vorgestellt, die Rigidheit der betrachteten Szene voraussetzt. Die Registrierung schätzt die Kamerabewegung zwischen den Bildern und gewinnt ihre Effizienz durch die Ausnutzung der kompakten multi-resolutionalen Darstellung der Karten. Die Registrierungsmethode erzielt hohe Bildverarbeitungsraten auf einer CPU. Wir demonstrieren hohe Effizienz, Genauigkeit und Robustheit unserer Methode im Vergleich zum bisherigen Stand der Forschung auf Vergleichsdatensätzen. In einem weiteren Registrierungsansatz lösen wir uns von der Annahme, dass die betrachtete Szene zwischen Bildern statisch ist. Wir erlauben nun, dass sich rigide Teile der Szene bewegen dürfen, und erweitern unser rigides Registrierungsverfahren auf diesen Fall. Unser Ansatz segmentiert das Bild in Bereiche einzelner Teile, die sich unterschiedlich zwischen Bildern bewegen. Wir demonstrieren hohe Segmentierungsgenauigkeit und Genauigkeit in der Bewegungsschätzung unter Echtzeitbedingungen für die Verarbeitung. Schließlich entwickeln wir ein Verfahren für die Wahrnehmung von nicht-rigiden Deformationen zwischen zwei MRSMaps. Auch hier nutzen wir die multi-resolutionale Struktur in den Karten für ein effizientes Registrieren von grob zu fein. Wir schlagen Methoden vor, um aus den geschätzten Deformationen die lokale Bewegung zwischen den Bildern zu berechnen. Wir evaluieren Genauigkeit und Effizienz des Registrierungsverfahrens. Der zweite Teil dieser Arbeit widmet sich der Verwendung unserer Kartenrepräsentation und Registrierungsmethoden für die Wahrnehmung von Szenen und Objekten. Wir verwenden MRSMaps und unsere rigide Registrierungsmethode, um dichte 3D Modelle von Szenen und Objekten zu lernen. Die räumlichen Beziehungen zwischen Schlüsselansichten, die wir durch Registrierung schätzen, werden in einem Simultanen Lokalisierungs- und Kartierungsverfahren (engl. simultaneous localization and mapping, SLAM) gegeneinander abgewogen, um die Blickposen der Schlüsselansichten zu schätzen. Für das Verfolgen der Kamerapose bezüglich der Modelle in Echtzeit, kombinieren wir die Genauigkeit unserer Registrierung mit der Robustheit von Partikelfiltern. Zu Beginn der Posenverfolgung, oder wenn das Objekt aufgrund von Verdeckungen oder extremen Bewegungen nicht weiter verfolgt werden konnte, initialisieren wir das Filter durch Objektdetektion. Anschließend wenden wir unsere erweiterten Registrierungsverfahren für die Wahrnehmung in nicht-rigiden Szenen und für die Übertragung von Objekthandhabungsfähigkeiten von Robotern an. Wir erweitern unseren rigiden Kartierungsansatz auf dynamische Szenen, in denen sich rigide Teile bewegen. Die Bewegungssegmente in Schlüsselansichten werden zueinander in Bezug gesetzt, um Äquivalenz- und Teilebeziehungen von Objekten probabilistisch zu inferieren, denen die Segmente entsprechen. Auch hier liefert unsere Registrierungsmethode die Bewegung der Kamera bezüglich der Objekte, die wir in einem SLAM Verfahren optimieren. Aus diesen Blickposen wiederum können wir die Bewegungssegmente in dichten Objektmodellen vereinen. Objekte einer Klasse teilen oft eine gemeinsame Topologie von funktionalen Elementen, die durch Formkorrespondenzen ermittelt werden kann. Wir verwenden unsere deformierbare Registrierung, um solche Korrespondenzen zu finden und die Handhabung eines Objektes durch einen Roboter auf neue Objektinstanzen derselben Klasse zu übertragen. Schließlich entwickeln wir einen echtzeitfähigen Ansatz, der Kategorien von Objekten in RGB-D Bildern erkennt und segmentiert. Die Segmentierung basiert auf Ensemblen randomisierter Entscheidungsbäume, die Geometrie- und Texturmerkmale zur Klassifikation verwenden. Wir fusionieren Segmentierungen von Einzelbildern einer Szene aus mehreren Ansichten in einer semantischen Objektklassenkarte mit Hilfe unseres SLAM-Verfahrens. Die vorgestellten Methoden werden auf öffentlich verfügbaren Vergleichsdatensätzen und eigenen Datensätzen evaluiert. Einige unserer Ansätze wurden auch in integrierten Robotersystemen für mobile Objekthantierungsaufgaben öffentlich demonstriert. Sie waren ein wichtiger Bestandteil für das Gewinnen der RoboCup-Roboterwettbewerbe in der RoboCup@Home Liga in den Jahren 2011, 2012 und 2013

Pattern Recognition and Event Reconstruction in Particle Physics Experiments

This report reviews methods of pattern recognition and event reconstruction used in modern high energy physics experiments. After a brief introduction into general concepts of particle detectors and statistical evaluation, different approaches in global and local methods of track pattern recognition are reviewed with their typical strengths and shortcomings. The emphasis is then moved to methods which estimate the particle properties from the signals which pattern recognition has associated. Finally, the global reconstruction of the event is briefly addressed.Comment: 101 pages, 58 figure

Automated Visual Database Creation For A Ground Vehicle Simulator

This research focuses on extracting road models from stereo video sequences taken from a moving vehicle. The proposed method combines color histogram based segmentation, active contours (snakes) and morphological processing to extract road boundary coordinates for conversion into Matlab or Multigen OpenFlight compatible polygonal representations. Color segmentation uses an initial truth frame to develop a color probability density function (PDF) of the road versus the terrain. Subsequent frames are segmented using a Maximum Apostiori Probability (MAP) criteria and the resulting templates are used to update the PDFs. Color segmentation worked well where there was minimal shadowing and occlusion by other cars. A snake algorithm was used to find the road edges which were converted to 3D coordinates using stereo disparity and vehicle position information. The resulting 3D road models were accurate to within 1 meter

Model and Appearance Based Analysis of Neuronal Morphology from Different Microscopy Imaging Modalities

The neuronal morphology analysis is key for understanding how a brain works. This process requires the neuron imaging system with single-cell resolution; however, there is no feasible system for the human brain. Fortunately, the knowledge can be inferred from the model organism, Drosophila melanogaster, to the human system. This dissertation explores the morphology analysis of Drosophila larvae at single-cell resolution in static images and image sequences, as well as multiple microscopy imaging modalities. Our contributions are on both computational methods for morphology quantification and analysis of the influence of the anatomical aspect. We develop novel model-and-appearance-based methods for morphology quantification and illustrate their significance in three neuroscience studies. Modeling of the structure and dynamics of neuronal circuits creates understanding about how connectivity patterns are formed within a motor circuit and determining whether the connectivity map of neurons can be deduced by estimations of neuronal morphology. To address this problem, we study both boundary-based and centerline-based approaches for neuron reconstruction in static volumes. Neuronal mechanisms are related to the morphology dynamics; so the patterns of neuronal morphology changes are analyzed along with other aspects. In this case, the relationship between neuronal activity and morphology dynamics is explored to analyze locomotion procedures. Our tracking method models the morphology dynamics in the calcium image sequence designed for detecting neuronal activity. It follows the local-to-global design to handle calcium imaging issues and neuronal movement characteristics. Lastly, modeling the link between structural and functional development depicts the correlation between neuron growth and protein interactions. This requires the morphology analysis of different imaging modalities. It can be solved using the part-wise volume segmentation with artificial templates, the standardized representation of neurons. Our method follows the global-to-local approach to solve both part-wise segmentation and registration across modalities. Our methods address common issues in automated morphology analysis from extracting morphological features to tracking neurons, as well as mapping neurons across imaging modalities. The quantitative analysis delivered by our techniques enables a number of new applications and visualizations for advancing the investigation of phenomena in the nervous system