Context-specific method for detection of soft-tissue lesions in non-cathartic low-dose dual-energy CT colonography

In computed tomographic colonography (CTC), orally administered fecal-tagging agents can be used to indicate residual feces and fluid that could otherwise hide or imitate lesions on CTC images of the colon. Although the use of fecal tagging improves the detection accuracy of CTC, it can introduce image artifacts that may cause lesions that are covered by fecal tagging to have a different visual appearance than those not covered by fecal tagging. This can distort the values of image-based computational features, thereby reducing the accuracy of computer-aided detection (CADe). We developed a context-specific method that performs the detection of lesions separately on lumen regions covered by air and on those covered by fecal tagging, thereby facilitating the optimization of detection parameters separately for these regions and their detected lesion candidates to improve the detection accuracy of CADe. For pilot evaluation, the method was integrated into a dual-energy CADe (DE-CADe) scheme and evaluated by use of leave-one-patient-out evaluation on 66 clinical non-cathartic low-dose dual-energy CTC (DE-CTC) cases that were acquired at a low effective radiation dose and reconstructed by use of iterative image reconstruction. There were 22 colonoscopy-confirmed lesions ≥6 mm in size in 21 patients. The DE-CADe scheme detected 96% of the lesions at a median of 6 FP detections per patient. These preliminary results indicate that the use of context-specific detection can yield high detection accuracy of CADe in non-cathartic low-dose DE-CTC examinations

Information-Preserving Pseudo-Enhancement Correction for Non-Cathartic Low-Dose Dual-Energy CT Colonography

In CT colonography (CTC), orally administered positive-contrast fecal-tagging agents can cause artificial elevation of the observed radiodensity of adjacent soft tissue. Such pseudo-enhancement makes it challenging to differentiate polyps and folds reliably from tagged materials, and it is also present in dual-energy CTC (DE-CTC). We developed a method that corrects for pseudo-enhancement on DE-CTC images without distorting the dual-energy information contained in the data. A pilot study was performed to evaluate the effect of the method visually and quantitatively by use of clinical non-cathartic low-dose DE-CTC data from 10 patients including 13 polyps covered partially or completely by iodine-based fecal tagging. The results indicate that the proposed method can be used to reduce the pseudo-enhancement distortion of DE-CTC images without losing material-specific dual-energy information. The method has potential application in improving the accuracy of automated image-processing applications, such as computer-aided detection and virtual bowel cleansing in CTC