9,451 research outputs found
copulaedas: An R Package for Estimation of Distribution Algorithms Based on Copulas
The use of copula-based models in EDAs (estimation of distribution
algorithms) is currently an active area of research. In this context, the
copulaedas package for R provides a platform where EDAs based on copulas can be
implemented and studied. The package offers complete implementations of various
EDAs based on copulas and vines, a group of well-known optimization problems,
and utility functions to study the performance of the algorithms. Newly
developed EDAs can be easily integrated into the package by extending an S4
class with generic functions for their main components. This paper presents
copulaedas by providing an overview of EDAs based on copulas, a description of
the implementation of the package, and an illustration of its use through
examples. The examples include running the EDAs defined in the package,
implementing new algorithms, and performing an empirical study to compare the
behavior of different algorithms on benchmark functions and a real-world
problem
Application of new probabilistic graphical models in the genetic regulatory networks studies
This paper introduces two new probabilistic graphical models for
reconstruction of genetic regulatory networks using DNA microarray data. One is
an Independence Graph (IG) model with either a forward or a backward search
algorithm and the other one is a Gaussian Network (GN) model with a novel
greedy search method. The performances of both models were evaluated on four
MAPK pathways in yeast and three simulated data sets. Generally, an IG model
provides a sparse graph but a GN model produces a dense graph where more
information about gene-gene interactions is preserved. Additionally, we found
two key limitations in the prediction of genetic regulatory networks using DNA
microarray data, the first is the sufficiency of sample size and the second is
the complexity of network structures may not be captured without additional
data at the protein level. Those limitations are present in all prediction
methods which used only DNA microarray data.Comment: 38 pages, 3 figure
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