7,611 research outputs found

    Fundamental Limitations of Disturbance Attenuation in the Presence of Side Information

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    In this paper, we study fundamental limitations of disturbance attenuation of feedback systems, under the assumption that the controller has a finite horizon preview of the disturbance. In contrast with prior work, we extend Bode's integral equation for the case where the preview is made available to the controller via a general, finite capacity, communication system. Under asymptotic stationarity assumptions, our results show that the new fundamental limitation differs from Bode's only by a constant, which quantifies the information rate through the communication system. In the absence of asymptotic stationarity, we derive a universal lower bound which uses Shannon's entropy rate as a measure of performance. By means of a case-study, we show that our main bounds may be achieved

    The infochemical core

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    Vocalizations, and less often gestures, have been the object of linguistic research for decades. However, the development of a general theory of communication with human language as a particular case requires a clear understanding of the organization of communication through other means. Infochemicals are chemical compounds that carry information and are employed by small organisms that cannot emit acoustic signals of an optimal frequency to achieve successful communication. Here, we investigate the distribution of infochemicals across species when they are ranked by their degree or the number of species with which they are associated (because they produce them or are sensitive to them). We evaluate the quality of the fit of different functions to the dependency between degree and rank by means of a penalty for the number of parameters of the function. Surprisingly, a double Zipf (a Zipf distribution with two regimes, each with a different exponent) is the model yielding the best fit although it is the function with the largest number of parameters. This suggests that the worldwide repertoire of infochemicals contains a core which is shared by many species and is reminiscent of the core vocabularies found for human language in dictionaries or large corpora.Peer ReviewedPostprint (author's final draft

    Inference of the genetic network regulating lateral root initiation in Arabidopsis thaliana

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    Regulation of gene expression is crucial for organism growth, and it is one of the challenges in Systems Biology to reconstruct the underlying regulatory biological networks from transcriptomic data. The formation of lateral roots in Arabidopsis thaliana is stimulated by a cascade of regulators of which only the interactions of its initial elements have been identified. Using simulated gene expression data with known network topology, we compare the performance of inference algorithms, based on different approaches, for which ready-to-use software is available. We show that their performance improves with the network size and the inclusion of mutants. We then analyse two sets of genes, whose activity is likely to be relevant to lateral root initiation in Arabidopsis, by integrating sequence analysis with the intersection of the results of the best performing methods on time series and mutants to infer their regulatory network. The methods applied capture known interactions between genes that are candidate regulators at early stages of development. The network inferred from genes significantly expressed during lateral root formation exhibits distinct scale-free, small world and hierarchical properties and the nodes with a high out-degree may warrant further investigation
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