Modeling sparse connectivity between underlying brain sources for EEG/MEG

We propose a novel technique to assess functional brain connectivity in EEG/MEG signals. Our method, called Sparsely-Connected Sources Analysis (SCSA), can overcome the problem of volume conduction by modeling neural data innovatively with the following ingredients: (a) the EEG is assumed to be a linear mixture of correlated sources following a multivariate autoregressive (MVAR) model, (b) the demixing is estimated jointly with the source MVAR parameters, (c) overfitting is avoided by using the Group Lasso penalty. This approach allows to extract the appropriate level cross-talk between the extracted sources and in this manner we obtain a sparse data-driven model of functional connectivity. We demonstrate the usefulness of SCSA with simulated data, and compare to a number of existing algorithms with excellent results.Comment: 9 pages, 6 figure

Flexible methods for blind separation of complex signals

One of the main matter in Blind Source Separation (BSS) performed with a neural network approach is the choice of the nonlinear activation function (AF). In fact if the shape of the activation function is chosen as the cumulative density function (c.d.f.) of the original source the problem is solved. For this scope in this thesis a flexible approach is introduced and the shape of the activation functions is changed during the learning process using the so-called “spline functions”. The problem is complicated in the case of separation of complex sources where there is the problem of the dichotomy between analyticity and boundedness of the complex activation functions. The problem is solved introducing the “splitting function” model as activation function. The “splitting function” is a couple of “spline function” which wind off the real and the imaginary part of the complex activation function, each of one depending from the real and imaginary variable. A more realistic model is the “generalized splitting function”, which is formed by a couple of two bi-dimensional functions (surfaces), one for the real and one for the imaginary part of the complex function, each depending by both the real and imaginary part of the complex variable. Unfortunately the linear environment is unrealistic in many practical applications. In this way there is the need of extending BSS problem in the nonlinear environment: in this case both the activation function than the nonlinear distorting function are realized by the “splitting function” made of “spline function”. The complex and instantaneous separation in linear and nonlinear environment allow us to perform a complex-valued extension of the well-known INFOMAX algorithm in several practical situations, such as convolutive mixtures, fMRI signal analysis and bandpass signal transmission. In addition advanced characteristics on the proposed approach are introduced and deeply described. First of all it is shows as splines are universal nonlinear functions for BSS problem: they are able to perform separation in anyway. Then it is analyzed as the “splitting solution” allows the algorithm to obtain a phase recovery: usually there is a phase ambiguity. Finally a Cramér-Rao lower bound for ICA is discussed. Several experimental results, tested by different objective indexes, show the effectiveness of the proposed approaches

Flexible methods for blind separation of complex signals

One of the main matter in Blind Source Separation (BSS) performed with a neural network approach is the choice of the nonlinear activation function (AF). In fact if the shape of the activation function is chosen as the cumulative density function (c.d.f.) of the original source the problem is solved. For this scope in this thesis a flexible approach is introduced and the shape of the activation functions is changed during the learning process using the so-called “spline functions”. The problem is complicated in the case of separation of complex sources where there is the problem of the dichotomy between analyticity and boundedness of the complex activation functions. The problem is solved introducing the “splitting function” model as activation function. The “splitting function” is a couple of “spline function” which wind off the real and the imaginary part of the complex activation function, each of one depending from the real and imaginary variable. A more realistic model is the “generalized splitting function”, which is formed by a couple of two bi-dimensional functions (surfaces), one for the real and one for the imaginary part of the complex function, each depending by both the real and imaginary part of the complex variable. Unfortunately the linear environment is unrealistic in many practical applications. In this way there is the need of extending BSS problem in the nonlinear environment: in this case both the activation function than the nonlinear distorting function are realized by the “splitting function” made of “spline function”. The complex and instantaneous separation in linear and nonlinear environment allow us to perform a complex-valued extension of the well-known INFOMAX algorithm in several practical situations, such as convolutive mixtures, fMRI signal analysis and bandpass signal transmission. In addition advanced characteristics on the proposed approach are introduced and deeply described. First of all it is shows as splines are universal nonlinear functions for BSS problem: they are able to perform separation in anyway. Then it is analyzed as the “splitting solution” allows the algorithm to obtain a phase recovery: usually there is a phase ambiguity. Finally a Cramér-Rao lower bound for ICA is discussed. Several experimental results, tested by different objective indexes, show the effectiveness of the proposed approaches