Duhem Before Breakfast

This essay traces some of Pierre Duhem's motives for his celebrated "Quine- Duhem thesis" to a specific worry about theory underdetermination that arises within classical mechanics, concerned with the rivalry between Duhem's own thermomechanical approach and the more narrowly "mechanical" treatment pursued by Hertz and others. In the context of the treatments of "physical infinitesimals" common at the time, these two approaches seem empirically indistinguishable. After an exposition of the basic issues, this alleged "underdetermination" is then evaluated from a more modern perspective

Automated biowaste sampling system improved feces collection, mass measurement and sampling

The capability of the basic automated Biowaste Sampling System (ABSS) hardware was extended and improved through the design, fabrication and test of breadboard hardware. A preliminary system design effort established the feasibility of integrating the breadboard concepts into the ABSS

Shell-models of RMHD turbulence and the heating of solar coronal loops

A simplified non-linear numerical model for the development of incompressible magnetohydrodynamics (MHD) in the presence of a strong magnetic field B0 and stratification, nicknamed Shell-Atm, is presented. In planes orthogonal to the mean field, the non-linear incompressible dynamics is replaced by 2D shell-models for the complex variables u and b, allowing one to reach large Reynolds numbers while at the same time carrying out sufficiently long time integrations to obtain a good statistics at moderate computational cost. The shell-models of different planes are coupled by Alfven waves propagating along B0. The model may be applied to open or closed magnetic field configurations where the axial field dominates and the plasma pressure is low; here we apply it to the specific case of a magnetic loop of the solar corona heated via turbulence driven by photospheric motions, and we use statistics for its analysis. The Alfven waves interact non-linearly and form turbulent spectra in the directions perpendicular and, via propagation, also parallel to the mean field. A heating function is obtained, and is shown to be intermittent; the average heating is consistent with values required for sustaining a hot corona, and is proportional to the aspect ratio of the loop to the power -1.5; characteristic properties of heating events are distributed as power-laws. Cross-correlations show a delay of dissipation compared to energy content.Comment: 12 pages, 16 figures, accepted for publication in Ap

Design of an active helicopter control experiment at the Princeton Rotorcraft Dynamics Laboratory

In an effort to develop an active control technique for reducing helicopter vibrations stemming from the main rotor system, a helicopter model was designed and tested at the Princeton Rotorcraft Dynamics Laboratory (PRDL). A description of this facility, including its latest data acquisition upgrade, are given. The design procedures for the test model and its Froude scaled rotor system are also discussed. The approach for performing active control is based on the idea that rotor states can be identified by instrumenting the rotor blades. Using this knowledge, Individual Blade Control (IBC) or Higher Harmonic Control (HHC) pitch input commands may be used to impact on rotor dynamics in such a way as to reduce rotor vibrations. Discussed here is an instrumentation configuration utilizing miniature accelerometers to measure and estimate first and second out-of-plane bending mode positions and velocities. To verify this technique, the model was tested, and resulting data were used to estimate rotor states as well as flap and bending coefficients, procedures for which are discussed. Overall results show that a cost- and time-effective method for building a useful test model for future active control experiments was developed. With some fine-tuning or slight adjustments in sensor configuration, prospects for obtaining good state estimates look promising

The role of ultrasound-driven microbubble dynamics in drug delivery : from microbubble fundamentals to clinical translation

In the last couple of decades, ultrasound-driven microbubbles have proven excellent candidates for local drug delivery applications. Besides being useful drug carriers, microbubbles have demonstrated the ability to enhance cell and tissue permeability and, as a consequence, drug uptake herein. Notwithstanding the large amount of evidence for their therapeutic efficacy, open issues remain. Because of the vast number of ultrasound- and microbubble-related parameters that can be altered and the variability in different models, the translation from basic research to (pre)clinical studies has been hindered. This review aims at connecting the knowledge gained from fundamental microbubble studies to the therapeutic efficacy seen in in vitro and in vivo studies, with an emphasis on a better understanding of the response of a microbubble upon exposure to ultrasound and its interaction with cells and tissues. More specifically, we address the acoustic settings and microbubble-related parameters (i.e., bubble size and physicochemistry of the bubble shell) that play a key role in microbubble cell interactions and in the associated therapeutic outcome. Additionally, new techniques that may provide additional control over the treatment, such as monodisperse microbubble formulations, tunable ultrasound scanners, and cavitation detection techniques, are discussed. An in-depth understanding of the aspects presented in this work could eventually lead the way to more efficient and tailored microbubble-assisted ultrasound therapy in the future

Design of a fault tolerant airborne digital computer. Volume 2: Computational requirements and technology

This final report summarizes the work on the design of a fault tolerant digital computer for aircraft. Volume 2 is composed of two parts. Part 1 is concerned with the computational requirements associated with an advanced commercial aircraft. Part 2 reviews the technology that will be available for the implementation of the computer in the 1975-1985 period. With regard to the computation task 26 computations have been categorized according to computational load, memory requirements, criticality, permitted down-time, and the need to save data in order to effect a roll-back. The technology part stresses the impact of large scale integration (LSI) on the realization of logic and memory. Also considered was module interconnection possibilities so as to minimize fault propagation

Researcher's guide to the NASA Ames Flight Simulator for Advanced Aircraft (FSAA)

Performance, limitations, supporting software, and current checkout and operating procedures are presented for the flight simulator, in terms useful to the researcher who intends to use it. Suggestions to help the researcher prepare the experimental plan are also given. The FSAA's central computer, cockpit, and visual and motion systems are addressed individually but their interaction is considered as well. Data required, available options, user responsibilities, and occupancy procedures are given in a form that facilitates the initial communication required with the NASA operations' group