104,627 research outputs found
Inductive queries for a drug designing robot scientist
It is increasingly clear that machine learning algorithms need to be integrated in an iterative scientific discovery loop, in which data is queried repeatedly by means of inductive queries and where the computer provides guidance to the experiments that are being performed. In this chapter, we summarise several key challenges in achieving this integration of machine learning and data mining algorithms in methods for the discovery of Quantitative Structure Activity Relationships (QSARs). We introduce the concept of a robot scientist, in which all steps of the discovery process are automated; we discuss the representation of molecular data such that knowledge discovery tools can analyse it, and we discuss the adaptation of machine learning and data mining algorithms to guide QSAR experiments
A Generic Conceptual Model for Risk Analysis in a Multi-agent Based Collaborative Design Environment
Organised by: Cranfield UniversityThis paper presents a generic conceptual model of risk evaluation in order to manage the risk through
related constraints and variables under a multi-agent collaborative design environment. Initially, a hierarchy
constraint network is developed to mapping constraints and variables. Then, an effective approximation
technique named Risk Assessment Matrix is adopted to evaluate risk level and rank priority after probability
quantification and consequence validation. Additionally, an Intelligent Data based Reasoning Methodology
is expanded to deal with risk mitigation by combining inductive learning methods and reasoning
consistency algorithms with feasible solution strategies. Finally, two empirical studies were conducted to
validate the effectiveness and feasibility of the conceptual model.Mori Seiki – The Machine Tool Compan
IC-Service: A Service-Oriented Approach to the Development of Recommendation Systems
Recommendation systems have proven to be useful in various application domains. However, current solutions are usually ad-hoc systems which are tightly-coupled with the application domain. We present the IC-Service, a recommendation service that can be included in any system in a loosely coupled way. The implementation follows the principles of service oriented computing and provides a solution to various problems arising in recommendation systems, e.g. to the problem of meta-recommendation systems development. Moreover, when properly configured, the IC-Service can be used by different applications (clients), and several independent instances of the IC-Service can collaborate to produce better recommendations. Service architecture and communication protocols are presented. The paper describes also ongoing work and applications based on the IC-Service
Difference to Inference: teaching logical and statistical reasoning through on-line interactivity
Journal ArticleDifference to Inference is an on-line JAVA program that simulates theory testing and falsification through research design and data collection in a game format. The program, based on cognitive and epistemological principles, is designed to support learning of the thinking skills underlying deductive and inductive logic and statistical reasoning. Difference to Inference has database connectivity so that game scores can be counted as part of course grades
Numerical investigation of novel microwave applicators based on zero-order mode resonance for hyperthermia treatment of cancer
This paper characterizes three novel microwave applicators based on zero-order mode resonators for use in hyperthermia treatment of cancer. The radiation patterns are studied with numerical simulations in muscle tissue-equivalent model at 434 MHz. The relative performance of the applicators is compared in terms of reflection coefficient, current distribution, power deposition (SAR) pattern, effective field size in 2D and 3D tissue volumes, and penetration depth. One particular configuration generated the most uniform SAR pattern, with 25% SAR covering 84 % of the treatment volume extending to 1 cm depth under the aperture, while remaining above 58% coverage as deep as 3 cm under the aperture. Recommendations are made to further optimize this structure
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