1,054 research outputs found
Normalized Web Distance and Word Similarity
There is a great deal of work in cognitive psychology, linguistics, and
computer science, about using word (or phrase) frequencies in context in text
corpora to develop measures for word similarity or word association, going back
to at least the 1960s. The goal of this chapter is to introduce the
normalizedis a general way to tap the amorphous low-grade knowledge available
for free on the Internet, typed in by local users aiming at personal
gratification of diverse objectives, and yet globally achieving what is
effectively the largest semantic electronic database in the world. Moreover,
this database is available for all by using any search engine that can return
aggregate page-count estimates for a large range of search-queries. In the
paper introducing the NWD it was called `normalized Google distance (NGD),' but
since Google doesn't allow computer searches anymore, we opt for the more
neutral and descriptive NWD. web distance (NWD) method to determine similarity
between words and phrases. ItComment: Latex, 20 pages, 7 figures, to appear in: Handbook of Natural
Language Processing, Second Edition, Nitin Indurkhya and Fred J. Damerau
Eds., CRC Press, Taylor and Francis Group, Boca Raton, FL, 2010, ISBN
978-142008592
Large-scale compression of genomic sequence databases with the Burrows-Wheeler transform
Motivation
The Burrows-Wheeler transform (BWT) is the foundation of many algorithms for
compression and indexing of text data, but the cost of computing the BWT of
very large string collections has prevented these techniques from being widely
applied to the large sets of sequences often encountered as the outcome of DNA
sequencing experiments. In previous work, we presented a novel algorithm that
allows the BWT of human genome scale data to be computed on very moderate
hardware, thus enabling us to investigate the BWT as a tool for the compression
of such datasets.
Results
We first used simulated reads to explore the relationship between the level
of compression and the error rate, the length of the reads and the level of
sampling of the underlying genome and compare choices of second-stage
compression algorithm.
We demonstrate that compression may be greatly improved by a particular
reordering of the sequences in the collection and give a novel `implicit
sorting' strategy that enables these benefits to be realised without the
overhead of sorting the reads. With these techniques, a 45x coverage of real
human genome sequence data compresses losslessly to under 0.5 bits per base,
allowing the 135.3Gbp of sequence to fit into only 8.2Gbytes of space (trimming
a small proportion of low-quality bases from the reads improves the compression
still further).
This is more than 4 times smaller than the size achieved by a standard
BWT-based compressor (bzip2) on the untrimmed reads, but an important further
advantage of our approach is that it facilitates the building of compressed
full text indexes such as the FM-index on large-scale DNA sequence collections.Comment: Version here is as submitted to Bioinformatics and is same as the
previously archived version. This submission registers the fact that the
advanced access version is now available at
http://bioinformatics.oxfordjournals.org/content/early/2012/05/02/bioinformatics.bts173.abstract
. Bioinformatics should be considered as the original place of publication of
this article, please cite accordingl
Space-efficient detection of unusual words
Detecting all the strings that occur in a text more frequently or less
frequently than expected according to an IID or a Markov model is a basic
problem in string mining, yet current algorithms are based on data structures
that are either space-inefficient or incur large slowdowns, and current
implementations cannot scale to genomes or metagenomes in practice. In this
paper we engineer an algorithm based on the suffix tree of a string to use just
a small data structure built on the Burrows-Wheeler transform, and a stack of
bits, where is the length of the string and
is the size of the alphabet. The size of the stack is except for very
large values of . We further improve the algorithm by removing its time
dependency on , by reporting only a subset of the maximal repeats and
of the minimal rare words of the string, and by detecting and scoring candidate
under-represented strings that in the string. Our
algorithms are practical and work directly on the BWT, thus they can be
immediately applied to a number of existing datasets that are available in this
form, returning this string mining problem to a manageable scale.Comment: arXiv admin note: text overlap with arXiv:1502.0637
Kernel methods in genomics and computational biology
Support vector machines and kernel methods are increasingly popular in
genomics and computational biology, due to their good performance in real-world
applications and strong modularity that makes them suitable to a wide range of
problems, from the classification of tumors to the automatic annotation of
proteins. Their ability to work in high dimension, to process non-vectorial
data, and the natural framework they provide to integrate heterogeneous data
are particularly relevant to various problems arising in computational biology.
In this chapter we survey some of the most prominent applications published so
far, highlighting the particular developments in kernel methods triggered by
problems in biology, and mention a few promising research directions likely to
expand in the future
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