Incremental Sparse Bayesian Ordinal Regression

Ordinal Regression (OR) aims to model the ordering information between different data categories, which is a crucial topic in multi-label learning. An important class of approaches to OR models the problem as a linear combination of basis functions that map features to a high dimensional non-linear space. However, most of the basis function-based algorithms are time consuming. We propose an incremental sparse Bayesian approach to OR tasks and introduce an algorithm to sequentially learn the relevant basis functions in the ordinal scenario. Our method, called Incremental Sparse Bayesian Ordinal Regression (ISBOR), automatically optimizes the hyper-parameters via the type-II maximum likelihood method. By exploiting fast marginal likelihood optimization, ISBOR can avoid big matrix inverses, which is the main bottleneck in applying basis function-based algorithms to OR tasks on large-scale datasets. We show that ISBOR can make accurate predictions with parsimonious basis functions while offering automatic estimates of the prediction uncertainty. Extensive experiments on synthetic and real word datasets demonstrate the efficiency and effectiveness of ISBOR compared to other basis function-based OR approaches

Machine Learning and Integrative Analysis of Biomedical Big Data.

Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome) is analyzed in isolation using statistical and machine learning (ML) methods. Integrative analysis of multi-omics and clinical data is key to new biomedical discoveries and advancements in precision medicine. However, data integration poses new computational challenges as well as exacerbates the ones associated with single-omics studies. Specialized computational approaches are required to effectively and efficiently perform integrative analysis of biomedical data acquired from diverse modalities. In this review, we discuss state-of-the-art ML-based approaches for tackling five specific computational challenges associated with integrative analysis: curse of dimensionality, data heterogeneity, missing data, class imbalance and scalability issues

Theoretical Interpretations and Applications of Radial Basis Function Networks

Medical applications usually used Radial Basis Function Networks just as Artificial Neural Networks. However, RBFNs are Knowledge-Based Networks that can be interpreted in several way: Artificial Neural Networks, Regularization Networks, Support Vector Machines, Wavelet Networks, Fuzzy Controllers, Kernel Estimators, Instanced-Based Learners. A survey of their interpretations and of their corresponding learning algorithms is provided as well as a brief survey on dynamic learning algorithms. RBFNs' interpretations can suggest applications that are particularly interesting in medical domains