Synchronization of coupled neural oscillators with heterogeneous delays

We investigate the effects of heterogeneous delays in the coupling of two excitable neural systems. Depending upon the coupling strengths and the time delays in the mutual and self-coupling, the compound system exhibits different types of synchronized oscillations of variable period. We analyze this synchronization based on the interplay of the different time delays and support the numerical results by analytical findings. In addition, we elaborate on bursting-like dynamics with two competing timescales on the basis of the autocorrelation function.Comment: 18 pages, 14 figure

Classification of coupled dynamical systems with multiple delays: Finding the minimal number of delays

In this article we study networks of coupled dynamical systems with time-delayed connections. If two such networks hold different delays on the connections it is in general possible that they exhibit different dynamical behavior as well. We prove that for particular sets of delays this is not the case. To this aim we introduce a componentwise timeshift transformation (CTT) which allows to classify systems which possess equivalent dynamics, though possibly different sets of connection delays. In particular, we show for a large class of semiflows (including the case of delay differential equations) that the stability of attractors is invariant under this transformation. Moreover we show that each equivalence class which is mediated by the CTT possesses a representative system in which the number of different delays is not larger than the cycle space dimension of the underlying graph. We conclude that the 'true' dimension of the corresponding parameter space of delays is in general smaller than it appears at first glance

Control of chaos in nonlinear circuits and systems

Nonlinear circuits and systems, such as electronic circuits (Chapter 5), power converters (Chapter 6), human brains (Chapter 7), phase lock loops (Chapter 8), sigma delta modulators (Chapter 9), etc, are found almost everywhere. Understanding nonlinear behaviours as well as control of these circuits and systems are important for real practical engineering applications. Control theories for linear circuits and systems are well developed and almost complete. However, different nonlinear circuits and systems could exhibit very different behaviours. Hence, it is difficult to unify a general control theory for general nonlinear circuits and systems. Up to now, control theories for nonlinear circuits and systems are still very limited. The objective of this book is to review the state of the art chaos control methods for some common nonlinear circuits and systems, such as those listed in the above, and stimulate further research and development in chaos control for nonlinear circuits and systems. This book consists of three parts. The first part of the book consists of reviews on general chaos control methods. In particular, a time-delayed approach written by H. Huang and G. Feng is reviewed in Chapter 1. A master slave synchronization problem for chaotic Lur’e systems is considered. A delay independent and delay dependent synchronization criteria are derived based on the H performance. The design of the time delayed feedback controller can be accomplished by means of the feasibility of linear matrix inequalities. In Chapter 2, a fuzzy model based approach written by H.K. Lam and F.H.F. Leung is reviewed. The synchronization of chaotic systems subject to parameter uncertainties is considered. A chaotic system is first represented by the fuzzy model. A switching controller is then employed to synchronize the systems. The stability conditions in terms of linear matrix inequalities are derived based on the Lyapunov stability theory. The tracking performance and parameter design of the controller are formulated as a generalized eigenvalue minimization problem which is solved numerically via some convex programming techniques. In Chapter 3, a sliding mode control approach written by Y. Feng and X. Yu is reviewed. Three kinds of sliding mode control methods, traditional sliding mode control, terminal sliding mode control and non-singular terminal sliding mode control, are employed for the control of a chaotic system to realize two different control objectives, namely to force the system states to converge to zero or to track desired trajectories. Observer based chaos synchronizations for chaotic systems with single nonlinearity and multi-nonlinearities are also presented. In Chapter 4, an optimal control approach written by C.Z. Wu, C.M. Liu, K.L. Teo and Q.X. Shao is reviewed. Systems with nonparametric regression with jump points are considered. The rough locations of all the possible jump points are identified using existing kernel methods. A smooth spline function is used to approximate each segment of the regression function. A time scaling transformation is derived so as to map the undecided jump points to fixed points. The approximation problem is formulated as an optimization problem and solved via existing optimization tools. The second part of the book consists of reviews on general chaos controls for continuous-time systems. In particular, chaos controls for Chua’s circuits written by L.A.B. Tôrres, L.A. Aguirre, R.M. Palhares and E.M.A.M. Mendes are discussed in Chapter 5. An inductorless Chua’s circuit realization is presented, as well as some practical issues, such as data analysis, mathematical modelling and dynamical characterization, are discussed. The tradeoff among the control objective, the control energy and the model complexity is derived. In Chapter 6, chaos controls for pulse width modulation current mode single phase H-bridge inverters written by B. Robert, M. Feki and H.H.C. Iu are discussed. A time delayed feedback controller is used in conjunction with the proportional controller in its simple form as well as in its extended form to stabilize the desired periodic orbit for larger values of the proportional controller gain. This method is very robust and easy to implement. In Chapter 7, chaos controls for epileptiform bursting in the brain written by M.W. Slutzky, P. Cvitanovic and D.J. Mogul are discussed. Chaos analysis and chaos control algorithms for manipulating the seizure like behaviour in a brain slice model are discussed. The techniques provide a nonlinear control pathway for terminating or potentially preventing epileptic seizures in the whole brain. The third part of the book consists of reviews on general chaos controls for discrete-time systems. In particular, chaos controls for phase lock loops written by A.M. Harb and B.A. Harb are discussed in Chapter 8. A nonlinear controller based on the theory of backstepping is designed so that the phase lock loops will not be out of lock. Also, the phase lock loops will not exhibit Hopf bifurcation and chaotic behaviours. In Chapter 9, chaos controls for sigma delta modulators written by B.W.K. Ling, C.Y.F. Ho and J.D. Reiss are discussed. A fuzzy impulsive control approach is employed for the control of the sigma delta modulators. The local stability criterion and the condition for the occurrence of limit cycle behaviours are derived. Based on the derived conditions, a fuzzy impulsive control law is formulated so that the occurrence of the limit cycle behaviours, the effect of the audio clicks and the distance between the state vectors and an invariant set are minimized supposing that the invariant set is nonempty. The state vectors can be bounded within any arbitrary nonempty region no matter what the input step size, the initial condition and the filter parameters are. The editors are much indebted to the editor of the World Scientific Series on Nonlinear Science, Prof. Leon Chua, and to Senior Editor Miss Lakshmi Narayan for their help and congenial processing of the edition

Mathematical frameworks for oscillatory network dynamics in neuroscience

The tools of weakly coupled phase oscillator theory have had a profound impact on the neuroscience community, providing insight into a variety of network behaviours ranging from central pattern generation to synchronisation, as well as predicting novel network states such as chimeras. However, there are many instances where this theory is expected to break down, say in the presence of strong coupling, or must be carefully interpreted, as in the presence of stochastic forcing. There are also surprises in the dynamical complexity of the attractors that can robustly appear—for example, heteroclinic network attractors. In this review we present a set of mathemat- ical tools that are suitable for addressing the dynamics of oscillatory neural networks, broadening from a standard phase oscillator perspective to provide a practical frame- work for further successful applications of mathematics to understanding network dynamics in neuroscience

Synchrony and bifurcations in coupled dynamical systems and effects of time delay

Dynamik auf Netzwerken ist ein mathematisches Feld, das in den letzten Jahrzehnten schnell gewachsen ist und Anwendungen in zahlreichen Disziplinen wie z.B. Physik, Biologie und Soziologie findet. Die Funktion vieler Netzwerke hängt von der Fähigkeit ab, die Elemente des Netzwerkes zu synchronisieren. Mit anderen Worten, die Existenz und die transversale Stabilität der synchronen Mannigfaltigkeit sind zentrale Eigenschaften. Erst seit einigen Jahren wird versucht, den verwickelten Zusammenhang zwischen der Kopplungsstruktur und den Stabilitätseigenschaften synchroner Zustände zu verstehen. Genau das ist das zentrale Thema dieser Arbeit. Zunächst präsentiere ich erste Ergebnisse zur Klassifizierung der Kanten eines gerichteten Netzwerks bezüglich ihrer Bedeutung für die Stabilität des synchronen Zustands. Folgend untersuche ich ein komplexes Verzweigungsszenario in einem gerichteten Ring von Stuart-Landau Oszillatoren und zeige, dass das Szenario persistent ist, wenn dem Netzwerk eine schwach gewichtete Kante hinzugefügt wird. Daraufhin untersuche ich synchrone Zustände in Ringen von Phasenoszillatoren die mit Zeitverzögerung gekoppelt sind. Ich bespreche die Koexistenz synchroner Lösungen und analysiere deren Stabilität und Verzweigungen. Weiter zeige ich, dass eine Zeitverschiebung genutzt werden kann, um Muster im Ring zu speichern und wiederzuerkennen. Diese Zeitverschiebung untersuche ich daraufhin für beliebige Kopplungsstrukturen. Ich zeige, dass invariante Mannigfaltigkeiten des Flusses sowie ihre Stabilität unter der Zeitverschiebung erhalten bleiben. Darüber hinaus bestimme ich die minimale Anzahl von Zeitverzögerungen, die gebraucht werden, um das System äquivalent zu beschreiben. Schließlich untersuche ich das auffällige Phänomen eines nichtstetigen Übergangs zu Synchronizität in Klassen großer Zufallsnetzwerke indem ich einen kürzlich eingeführten Zugang zur Beschreibung großer Zufallsnetzwerke auf den Fall zeitverzögerter Kopplungen verallgemeinere.Since a couple of decades, dynamics on networks is a rapidly growing branch of mathematics with applications in various disciplines such as physics, biology or sociology. The functioning of many networks heavily relies on the ability to synchronize the network’s nodes. More precisely, the existence and the transverse stability of the synchronous manifold are essential properties. It was only in the last few years that people tried to understand the entangled relation between the coupling structure of a network, given by a (di-)graph, and the stability properties of synchronous states. This is the central theme of this dissertation. I first present results towards a classification of the links in a directed, diffusive network according to their impact on the stability of synchronization. Then I investigate a complex bifurcation scenario observed in a directed ring of Stuart-Landau oscillators. I show that under the addition of a single weak link, this scenario is persistent. Subsequently, I investigate synchronous patterns in a directed ring of phase oscillators coupled with time delay. I discuss the coexistence of multiple of synchronous solutions and investigate their stability and bifurcations. I apply these results by showing that a certain time-shift transformation can be used in order to employ the ring as a pattern recognition device. Next, I investigate the same time-shift transformation for arbitrary coupling structures in a very general setting. I show that invariant manifolds of the flow together with their stability properties are conserved under the time-shift transformation. Furthermore, I determine the minimal number of delays needed to equivalently describe the system’s dynamics. Finally, I investigate a peculiar phenomenon of non-continuous transition to synchrony observed in certain classes of large random networks, generalizing a recently introduced approach for the description of large random networks to the case of delayed couplings

Stability and stabilization of sampled-data control for lure systems

Este trabalho apresenta um novo método para a análise de estabilidade e estabilização de sistemas do tipo Lure com controle amostrado, sujeitos a amostragem aperiódica e não linearidades que são limitadas em setor e restritas em derivada, em ambos contextos global e regional. Assume-se que os estados da planta estão disponíveis para medição e que as não linearidades são conhecidas, o que leva a uma formulação mais geral do problema. Os estados são adquiridos por um controlador digital que atualiza a entrada de controle em instantes de tempo discretos e aperiódicos, mantendo-a constante entre dois instantes sucessivos de amostragem. A abordagem apresentada neste trabalho é baseada no uso de uma nova classe de looped-functionals e em uma função do tipo Lure generalizada, que leva a condições de estabilidade e estabilização que são escritas na forma de desigualdades matriciais lineares (LMIs) e quasi-LMIs, respectivamente. Com base nestas condições, problemas de otimização são formulados com o objetivo de computar o intervalo máximo entre amostragens ou os limites máximos do setor para os quais a estabilidade assintótica da origem do sistema de dados amostrados em malha fechada é garantida. No caso em que as condições de setor são válidas apenas localmente, a solução desses problemas também fornece uma estimativa da região de atração para as trajetórias em tempo contínuo do sistema em malha fechada. Como as condições de síntese são quasi-LMIs, um algoritmo de otimização por enxame de partículas é proposto para lidar com as não linearidades envolvidas nos problemas de otimização, que surgem do produto de algumas variáveis de decisão. Exemplos numéricos são apresentados ao longo do trabalho para destacar as potencialidades do método.This work presents a new method for stability analysis and stabilization of sampleddata controlled Lure systems, subject to aperiodic sampling and nonlinearities that are sector bounded and slope restricted, in both global and regional contexts. We assume that the states of the plant are available for measurement and that the nonlinearities are known, which leads to a more general formulation of the problem. The states are acquired by a digital controller which updates the control input at aperiodic discrete-time instants, keeping it constant between successive sampling instants. The approach here presented is based on the use of a new class of looped-functionals and a generalized Luretype function, which leads to stability and stabilization conditions that are written in the form of Linear Matrix Inequalities (LMIs) and quasi-LMIs, respectively. On this basis, optimization problems are formulated aiming to compute the maximal intersampling interval or the maximal sector bounds for which the asymptotic stability of the origin of the sampled-data closed-loop system is guaranteed. In the case where the sector conditions hold only locally, the solution of these problems also provide an estimate of the region of attraction for the continuous-time trajectories of the closed-loop system. As the synthesis conditions are quasi-LMIs, a Particle Swarm Optimization (PSO) algorithm is proposed to deal with the involved nonlinearities in the optimization problems, which arise from the product of some decision variables. Numerical examples are presented throughout the work to highlight the potentialities of the method

The role of the medial prefrontal cortex in delay discounting

Indiana University-Purdue University Indianapolis (IUPUI)Increased delay discounting (DD) has been associated with and is theorized to contribute to alcoholism and substance abuse. It is also been associated with numerous other mental disorders and is believed to be a trans-disease process (i.e., a process that occurs in and contributes to multiple different pathologies). Consequently insights gained from studying DD are likely to apply to many different diseases. Studies on the neurobiological underpinnings of DD have two main interpretations. The first interpretation is that two different neurobehavioral systems exist, one favoring delayed rewards (executive system) and one favoring immediate rewards (impulsive system), and the system with the greater relative activation determines choice made by an individual. Alternatively, a single valuation system may exist. This system integrates different information about outcomes and generates a value signal that then guides decision making. Preclinical investigations have steered clear of these two different interpretations and rather focused on the role of individual structures in DD. One such structure, the rat mPFC, may generate an outcome representation of delayed rewards that is critically involved in attributing value to delayed rewards. Moreover, there is evidence indicating the rat mPFC may correspond to the primate dlPFC, an executive system structure. The current body of work set about testing the hypotheses that the mPFC is necessary for attributing value to delayed rewards and that decreasing the activity in an executive system area, and thus the executive system, shifts inter-temporal preference towards immediate rewards. To this end the rat mPFC was inactivated using an hM4Di inhibitory designer receptor exclusively activated by designer drugs (DREADD; experiment 1) or microinjections of tetrodotoxin (TTX; experiment 2) while animals completed an adjusting amount DD task. Activation of the hM4Di inhibitory DREADD receptor caused a decrease in DD, opposite of what was predicted. Electrophysiological recordings revealed a subpopulation of neurons actually increased their firing in response to hM4Di receptor activation, potentially explaining the unpredicted results. Microinjections of TTX to completely silence neural activity in the mPFC failed to produce a change in DD. Together both results indicate that mPFC activity is capable of manipulating but is not necessary for DD and the attribution of value to the delayed reward. Consequently, a secondary role for the rat mPFC in DD is proposed in line with single valuation system accounts of DD. Further investigations determining the primary structures responsible for sustaining delayed reward valuation and how manipulating the mPFC may be a means to decrease DD are warranted, and continued investigation that delineates the neurobiological processes of delayed reward valuation may provide valuable insight to both addiction and psychopathology

Discrete Time Systems

Discrete-Time Systems comprehend an important and broad research field. The consolidation of digital-based computational means in the present, pushes a technological tool into the field with a tremendous impact in areas like Control, Signal Processing, Communications, System Modelling and related Applications. This book attempts to give a scope in the wide area of Discrete-Time Systems. Their contents are grouped conveniently in sections according to significant areas, namely Filtering, Fixed and Adaptive Control Systems, Stability Problems and Miscellaneous Applications. We think that the contribution of the book enlarges the field of the Discrete-Time Systems with signification in the present state-of-the-art. Despite the vertiginous advance in the field, we also believe that the topics described here allow us also to look through some main tendencies in the next years in the research area